pharmacogenomics and personalized medicine in the treatment of human diseases

... forms of treatment i.e complementary/ alternative medicine (CAM) Traditional Chinese Medicine (TCM) is the most popular type of CAM for the treatment of cancer among the Chinese population in Singapore ... immunomodulatory and/ or anti-tumor effects and could palliate the side-effects (nausea, insomnia, pain and fatigue) of chemo- and radiotherapy The investigation was carried out in two phases In the clinical ... affordable form of health care, compared to the more sophisticated form of Western medicine Some of the clinics in Singapore, like the Chung Hwa Free Clinic, offer free consultation and treatment to...

Ngày tải lên: 15/09/2015, 17:10

... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks of ... pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous...

Ngày tải lên: 25/10/2012, 10:51

... provide written informed consent Use of other natural health products, including glucosamine and chondroitin, one month prior to study and during the study, other than multivitamin and mineral supplements ... capsule contains 375 mg of glucosamine HCl (USP Grade) and 300 mg of chondroitin sulfate (USP Grade) The subjects were instructed to take two G+C capsules in the morning and two in the evening for ... acetaminophen or ibuprofen within days of randomization Subject is unwilling to stop taking pain medication other than the study medication (for arthritis or other types of pain) or is unwilling...

Ngày tải lên: 26/10/2012, 09:48

... tissue and gastrointestinal tract, as well as other sites, are known to reach the CNS to effect changes in feeding behavior and energy expenditure Thus, insulin, leptin and ghrelin, as well as other ... closely and rapidly with reciprocal changes in the levels of the orexigenic and anorectic Signaling mediators in the treatment of obesity neuropeptide expression in the hypothalamus [22] Thus an increase ... explored further Other areas of the brain have also been shown to regulate feeding via AMPK [35,36] Of interest is the extensive use of fructose as a sweetener in the human diet [37] Glucose and fructose...

Ngày tải lên: 14/02/2014, 22:20

... at each phase of the cell cycle by various complexes of cell-cycle-related molecules, including cyclins, cyclin-dependent kinases, their inhibitors and the retinoblastoma protein (RB), as well ... calorie intake induces expression of RMI1 and E2Fs in adipocytes, and these changes in expression are expected to increase a positive interaction between the molecules The increased expression of ... recruitment of preadipocytes [12], suggesting that these cyclin-dependent kinase inhibitors are important in the regulation of adipocyte number The S-phase kinase-associated protein (Skp)1–CullinF-box...

Ngày tải lên: 06/03/2014, 01:20

... training (inducing muscle hypertrophy) or skill training (improving motor learning), and their exercise dosage (frequency, intensity, duration of the training programs and compliance) [10] The ... components of the training per se but rather the training effect may be enhanced through regular therapist contact for motivation Despite the number of studies including skill training in the PFMT ... providing a profile of each study using the following headings: • Information about service delivery (health professional and setting/institution) • Demographic information about the subjects in the...

Ngày tải lên: 28/03/2014, 14:20

... screening including erythrocyte sedimenta- Page of tion rate and C-reactive protein was normal Plain radiographs revealed areas of periprosthetic osteolysis in the femur and the tibia, and a ... image of the left knee showing the introducing cannula and simultaneous venting of the medial tibial condylar cyst Discussion When dealing with massive periprosthetic osteolysis the aims of surgery ... years later In January 2005 the patient began to develop similar medial pain and swelling in the left knee A bone scan showed increased activity in the medial femoral condyle indicating possible...

Ngày tải lên: 20/06/2014, 04:20

... Annals of General Psychiatry 2009, 8:16 the treatment of acute mania, the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine, ... dose at the end of the study was 15.5 mg daily The results suggest that in weeks to and then again at week there is a significant reduction in the MADRS scores in the aripiprazole group in comparison ... which included 66 of the 67 patients who completed the 26-week period Unfortunately only 12 of them (5 in the placebo group and in the aripiprazole group) completed the 74-week treatment period The...

Ngày tải lên: 08/08/2014, 23:21

... fluvoxamine binds to sigma-1 receptors in the intact human brain at therapeutic doses [25], suggesting that sigma-1 receptors are involved in the active mechanisms of fluvoxamine [19] Interestingly, ... effective in the treatment of psychotic major depression, and the switch to sertraline worsened the psychotic symptoms in the patient The mechanisms underlying the opposite effects of these two ... that activation of the dopaminergic system by the inhibition of dopamine transporter may be involved in the mechanism of unwanted effects (deterioration of psychosis) of sertarline in this case,...

Ngày tải lên: 08/08/2014, 23:21

... contributions All of the authors have been involved in drafting this paper and have read and approved the final manuscript KG conceived the idea of the paper, reported the case, performed the literature ... concerning radiotherapy and followed up the patient at his out-patient clinic AK was the radiologist performing the preoperative and postoperative CT and MRI scans and wrote the part of the paper ... radiotherapy and conventional fractionation while minimising the risks of RT-inducing brain injury like radiation necrosis and cognitive decline The optimal radiation dose has not yet been defined We...

Ngày tải lên: 09/08/2014, 09:20

... HT at the Tomotherapy Unit of the Grupo IMO in the context of multidisciplinary national and international treatment protocols All the patients were treated with curative intent, including those ... to the Tomotherapy treatment planning system (Tomotherapy Inc., Madison, WI) to perform inverse treatment planning The planning goal was to deliver the prescription dose to at least 95% of the ... treatment time was composed of time required for patient set-up and anesthesia inside the treatment room, time of MVCT acquisition, time of review/match and applying couch correction inside the...

Ngày tải lên: 09/08/2014, 09:21

... treatment of the children HB is responsible for the anaesthesia management of the children PH is responsible for the clinical treatment of the children as head of the division of radiation oncology in ... helical tomotherapy have the potential of selectively sparing the thyroid gland and breast tissue in craniospinal irradiation The number of children treated with IMRT and the hard evidence for the benefit ... percent of the IMRT Group had grade or hearing loss, compared to 64% of the conventional-RT group The sparing of the hearing apparatus is of special importance since several modern combined chemotherapy...

Ngày tải lên: 09/08/2014, 10:20

... according to the actuarial method of Kaplan and Meier [24] The calculation of OS, DFS and LC was performed from the date of diagnosis to the date of the event Survival was measured from the date of ... sphincter-sparing surgery is nowadays the main subject of controversy One of the most important controversies is whether the degree of downstaging warrants this type of surgery [1] Results of the ... treatment was temporarily interrupted The decision of performing this weekly CT schedule instead of during the first and last week of RT course had the objective of maximize the radiation effect Adjuvant...

Ngày tải lên: 09/08/2014, 10:20

... cystic carcinomas of the head and neck are a unique kind of tumour deriving from cells of the major and minor salivary glands, they account for 25% of all malignant salivary gland tumours in different ... material wrapped around the head of the patient Serial mm CT slices of the of the whole treatment area plus a superior margin of cm and an adequate inferior margin to cover the neck lymph nodes ... by slice on the treatment planning CTs using the 3D-conformal radiotherapy planning system VIRTUOS which was developed at the dkfz An image fusion of the treatment planning CT and the MRI scan...

Ngày tải lên: 09/08/2014, 10:21

... stages III and IV) Combining the studies, there were 439 patients, and over 98% of these were late-stage Treatment efficacy The main characteristics of the four studies are shown in table 3, ... of those met all inclusion criteria as studies of frontline or re -treatment Two of those four met the criteria for the first analysis (frontline treatment alone) Outcome The primary goal of the ... (53%) or R-CHOP (63%) The international PRIMA study testing the efficacy of maintenance therapy by rituximab may provide important data in the field of the best induction in patients with follicular...

Ngày tải lên: 10/08/2014, 22:20

... patients [12], TPMT and aziathropine, UGT1A1 and irinotecan, and others - showing the potential for personalized medicine development Future challenges Despite these promising and exciting results, ... promised land of Hulot Genome Medicine 2010, 2:13 http://genomemedicine.com/content/2/2/13 Page of Table Pharmacogenomics information on the top ten selling drugs in the world Generic name Therapeutic ... risk of having a cardiovascular ischemic event or of dying during the following year The findings from this first GWAS are in agreement with previous results from candidate gene studies in this...

Ngày tải lên: 11/08/2014, 12:20

... we assessed the proportion of patients receiving the service, the rate of use and rate of admissions, the time to first use of the service, and the annual health care cost, in terms of total health ... antipsychotic within 14 days of discontinuation of the initial therapy Data on the occurrence of acute-care service use, the time to the use of such services, and total-care and acute-care service ... hospitalization/day treatment, crisis services, and any acute-care services; as well as the total duration (in days) of each of these services and the rate of admissions to the facilities providing them Total and...

Ngày tải lên: 11/08/2014, 17:20

... participated in the design of the study and the analytical plan DEF participated in the design of the study, the analytical plan, the interpretation of the results, and assisted in drafting the manuscript ... manuscript DS and ES participated in the design of the study, the analytical plan, the interpretation of the results, and assisted in drafting the manuscript They were also involved in preparing the resource ... costing data of US-SCAP XP performed the expanded statistical analyses, participated in the design of the study, the analytical plan, and the interpretation of the results RRC assisted with the interpretation...

Ngày tải lên: 11/08/2014, 17:20

... contributions SG was involved in the conceptual design of this study, in the clinical management of the patient, and in the writing and editing of the manuscript VA was involved in the Page of (page number ... scan examinations VDF was involved in the clinical management and contributed to the writing and editing of the manuscript GM supervised the entire treatment, provided financial and administrative ... obtained from the patient at the beginning of each treatment A separate institutional informed consent was obtained at the first visit, with regard to the treatment of personal data and use in...

Ngày tải lên: 11/08/2014, 21:22

... approved the final manuscript Competing interests The funding source had no influence on study design, in the collection, analysis, and interpretation of the data, in the writing of the manuscript, ... telbivudine are more widely used in treatment of CHB In this systematic review, we focus on the comparison of the efficay of lamivudine and telbivudine in the Figure Effect of telbivudine vs lamivudine ... of the healthcare system is not satisfactory There are limitations in the reimbursement of anti-HBV therapy, either in the selection of agent or the duration of dosing Therefore, lamivudine and...

Ngày tải lên: 12/08/2014, 01:21