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... rate can thus be the result of a shift of the rate constants of the branched part of mechanism, i.e increased cleavage at the expense of complex formation Therefore, the products of the reaction ... binding of TM by thrombin Binding of the carboxy-terminal part of the reactive center loop of PAI-1 in the small cleft formed by the 60-loop and VR1 loop can be envisioned The kinetics of the interaction ... paid to the mitogenic effect of thrombin, and its control by PAI-1/VN in the pathogenesis of vascular disease [16,17] Together, the presence of PAI-1, VN and TM in the vessel wall, including the...

Ngày tải lên: 23/03/2014, 17:21

... triplicates of at least 3,000 nuclei whole plants grown for days in the light Figure shows the results The expression levels of the two BR biosynthetic genes, DWF4 and BR6OX2, increased in the calli of ... performed the experiments JC and SYP carried out the flow cytometry experiments BS analyzed the results and revised the manuscript SC was the principal investigator of the project; he designed and ... smaller in the roots of dwf7-1 relative to wild-type cells To examine cell division in the roots of intact plants, the percentage of cells in the three phases of the cell cycle–G1, S, and G2/M–were...

Ngày tải lên: 11/08/2014, 11:21

... presentation of the data shown in A and B Boxes indicate the upper and lower quartile (box borders), median (line within the box) and the maxima and minima of each data set (vertical lines) 1.0) [37] The ... expanding knowledge on the molecular details of the multi-faceted interactions of HIV with its host, the basic question of which viral factors and cell death mechanisms contribute to the loss of ... levels, the fact that significantly less p24+ cells are present in the absence of Nef suggests that the lack of Nef limits the infection of new target cells rather than affecting the amounts of particles...

Ngày tải lên: 13/08/2014, 05:21

... the same base as the segment and an equal height.3 Later, theorems worthy of mention suggested themselves to us, and we took the trouble of preparing their proofs They are these: first, that the ... the center of the sphere, I call the figure internally contained by the surface of the cone, and by the surface of the sphere inside the cone, a “solid sector.” /6/ And when two cones having the ... See the following note on purpose and practices of the critical edition of diagrams 2.3 Purpose and practices of the critical edition of diagrams The main purpose of the critical edition of diagrams...

Ngày tải lên: 21/09/2012, 11:00

... a candidate for the degree of Master of Arts (TEFL) accept the requirements of the College relating to the retention and use of Master of Arts Thesis deposited in the library In terms of these ... content, the extent to which the test scores are reliable and the students attitude towards the test and then to come to a final conclusion about the reliability of the test The findings of indicate ... students reduce the reliability of the test scores On the basis of these results, the author provides some suggestions towards the improvement of the test quality The reliability of the final achievement...

Ngày tải lên: 10/04/2013, 14:46

... years through the development and use of a succession of live food organisms as feed for the developing larvae The aim of the present manual was therefore to review and summarise the latest developments ... permission of the copyright owner Applications for such permission, with a statement of the purpose and extent of the reproduction, should be addressed to the Director, Information Division, Food and ... concerning the production and use of the major live food organisms currently employed in larviculture worldwide This document has been prepared within the framework of the aquaculture nutrition and...

Ngày tải lên: 15/12/2013, 00:15

... governance, the role of ethics and the agency issue  Understand the financial institutions and markets and the role they play in managerial finance  Discuss business taxes and their importance ... Define the managerial finance function and its relationship to economics and accounting  Identify the primary activities of the financial manager within a firm  Explain the goal of the firm, ... Financial Services: the design and delivery of advice and financial products to individuals, business and government – Managerial Finance: the duties of the financial manager in the business firm...

Ngày tải lên: 16/12/2013, 14:45

... test at the beginning of the school year The group of student was selected to be the target population of this research firstly because of the relative number of males and females in the group ... remember and the new words After some time, I usually forget the meaning and use of the words.” “If I see the words in the exercises many times, and the teacher explains the new words, then I can ... underline the new words in the reading text or write down the new words in a notebook Then I ask the teacher for the meaning and write down the meaning; sometimes look up the meaning of the new...

Ngày tải lên: 29/01/2014, 00:23

... 2–3 and 4– 5) Notably, JSP1 seemed to stimulate preferentially the phosphorylation of the p46 isoform of JNK, whereas sorbitol treatment induced phosphorylation of both the p46 and p55 isoforms ... on the stimulus and cellular context, the JNK pathway has been implicated in both apoptosis and cell survival [9] The duration and extent of MAPK activation depends not only on the activity of ... in the floating cells (Fig 5C) Taken together, these data indicated that JSP1-wt, but not the -G2A mutant, induced detachment of cells and induction of apoptosis, further demonstrating that the...

Ngày tải lên: 16/02/2014, 14:20

... 5), and the salt-bridge between E132 and R135 [18] contribute to the thermodynamic stability of the stressed conformation and/ or are important for the positioning of hF in a way delaying the ... mimicking the effect of the K325A substitution (Fig 5) Of note is that the side chain of E285 forms a hydrogen bond to the backbone of the hF/s3A-loop in PAI-1stab [18] (Fig 5) and in contrast with the ... stabilize the stressed conformation of these serpins by relieving the strain of side chain overpacking between the K325 side chain and residues in the hF/s3A-loop, i.e the conserved I150 and L153...

Ngày tải lên: 20/02/2014, 11:20

... the KpnI and XhoI sites in the vector and KpnI and SalI sites in the PCR2.1 clones of the promoter fragments All promoter constructs were sequenced to confirm their orientation and to verify their ... fgl2 mRNA The left side of the figure is the sequence ladder using the same primer and the pM166 clone as template Arrow indicates the nucleotide that is matched to the band present in the primer ... are indicated in the top of the panel Supershift, ss-Sp1 and ss-Sp3, were shown in presence of anti-Sp1 and anti-Sp3 Ig Cold and mutated competitors are indicated at the top of the figure probe...

Ngày tải lên: 20/02/2014, 11:20

... that the figures which fill the most prominent positions in the foreground of these pictures, are those of the most noble, most gifted, and Most distinguished men of the The Diary and Letters of ... eminently accomplished, and retaining, in spite of the infirmities of advanced age, the vigour of her faculties, and the serenity of her temper, enjoyed and deserved the favour of the royal family She ... then paced the cloisters of Magdalene, compared the antique gloom of Merton with the splendour of Christchurch, and looked down from the dome of the Radcliffe library on the magnificent sea of...

Ngày tải lên: 07/03/2014, 01:20

... spectra of the two domains permitted the full sequence-specific assignments, the identification of the spin systems and the assignment of 398 and 252 of the NOESY cross-peaks of the a- and b-domain, ... regardless of whether zinc or cadmium is bound to them and also regardless of the existence of the second domain The assigned peaks of the a-domain were integrated and their consistency with the published ... than five Taken together, the initial additions of Cu(I) to each domain caused the disappearance of a large set of NOESY cross-peaks and the parallel appearance of another set of cross-peaks, until...

Ngày tải lên: 07/03/2014, 09:20

... J Borloo et al A B C D other Statistical analysis (Student’s t-test) between the MR-1R values and the sum of the values of the omcA– and the omcB– mutants revealed that there is no statistically ... acceptor These results therefore provide evidence that there are differences between the electron transfer pathways towards chelated Fe(III) on the one hand and either U(VI) or Se(VI) on the other ... which the reduction potential and the topology and accessibility of the presented metal play crucial roles in terms of binding efficiencies and subsequent reduction by the appropriate enzyme The...

Ngày tải lên: 07/03/2014, 09:20

... similar Ga in mammals The amino acid sequence of GOA-1 is 82.2% identical to that of Gao Although the similarity of the aA–aE region and the region upstream of a4 was relatively low, the N-terminal ... decrease in the affinity for GDP of Ga and the subsequent substitution of GDP by GTP [10] Such an agonist-dependent decrease in the affinity for GDP can be detected as the increase in binding of the nonhydrolysable ... (aN–a1), the aF–aG region and the C-terminal region (a4–a5) were well conserved between GOA-1 and Gao [31,32] The five regions of the Ga-subunit involved in receptor recognition are the a2 helix, the...

Ngày tải lên: 07/03/2014, 11:20

... knowledge, and the pursuit of the subject’s True nature, the origins of which can be found in Christianity and its hermeneutics of the subject, and on the other hand the constitution of the subject ... of the danger unleashed by the death of God: “We are indeed the last man in the Nietzschean sense of the term, and the overman will be whoever can overcome the absence of God and the absence of ... rediscovered the point at which man and God belong to one another, at which the death of the second is synonymous with the disappearance of the first, and at which the promise of the overman signifies...

Ngày tải lên: 07/03/2014, 17:20

... inspection requirement for the project, and requires an understanding and knowledge of the various corrosion tests by the inspector Often these are done to ASTM specifications and the inspector must ... inspections of the fitup, the root pass, and the final weld, and were signed off after each of the three visual inspections This "visual inspection only" approach was used in lieu of the more conventional ... ready access to them Pressure containment usually requires the use of welding operations in the manufacturing of the piping and vessels needed In the fabrication of new equipment, the welding operations...

Ngày tải lên: 12/03/2014, 17:18

... n Proof We proceed as in the last half of the proof of the operator bounds, Lemma 2.7 Through a small modification, notably replacing δf by ∆, and making use of mixing, condition (T4), and the ... < +∞ Then µ-almost surely the various dimensions of the random Julia set J(f )ω , equation (4.21), agree and are given as the unique zero sc (f ) of the pressure function P (s, f ) from Theorem ... connectivity of U and the properties of our conformal maps The diameter of K is finite within U Given two points y and z in K, choose a geodesic between them of length not greater than the diameter of...

Ngày tải lên: 15/03/2014, 09:20

... allowing an understanding of species, tissue, age and pathology related differences and the estimation of changes in CS ⁄ DS abundance and composition However, the reduction of the polymer to its individual ... sources, from tissues of differing ages and also within a single chain Enhanced availability of data to facilitate the characterization of these structures is therefore of value GAGs are not ... region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(b1– 3)GalNAc(b1-]n, which may be O-sulfated on the C4 and ⁄ or C6 of GalNAc and C2 of...

Ngày tải lên: 16/03/2014, 14:20

... showing the facets of (a) the wire-like islands, (b) the elongated islands, and (c) the dot-like islands Fig 3b and c The dot-like islands adopt the facet structure of the elongated islands by ... of the island is determined by an integral of the work of the point force over the epitaxial contact area, relaxation of the island is therefore not only dependent on the stress of the island, ... island length and the number density The width of the island is $20 nm and the height of the island is $1.5 nm In comparison, growth of elongated islands mainly proceeds via increases in island...

Ngày tải lên: 16/03/2014, 15:34