fi cance of the fill factor

... mandarin fish [28], whereas Foxp3 has been characterized for the first time in fish The availability of sequenced fish genomes has allowed the discovery of a number of immune relevant genes using the ... differentiation of the naive T-cell to Th1, Th2, Th17 or Treg cells may exist in fish In this investigation, we have identified, for the first time, t-bet and stat6 in zebrafish and, for the first time in any fish ... unclear whether these cytokines are produced by CD4+CD25+Foxp3+Treg or whether they induce the production of these cytokines from another population of cells [20] To date, our knowledge about the different...

Ngày tải lên: 16/02/2014, 09:20

... from the global t The constant a is the ratio of apparent dissociation constants for binding GST-IjBa in the presence and absence of ATP, and the value of a indicates whether the binding of one ... substantiated that the oscillatory pattern of the model is affected when the new data is implemented in the model We next studied the impact of a rhIKK2 inhibitor on the oscillatory pattern of both cell-based ... Interestingly, the pretreated cells displayed clearly discernible oscillations that closely followed those of the untreated cells in terms of their frequency The effects of exposing the cells to the inhibitor...

Ngày tải lên: 16/03/2014, 11:20

... species-specific molecules Lens-specific transcription of aA-crystalline appears to involve cooperation of cCP2 with a putative lens-specific factor [14] Binding of CP2 to the stage selector element of the ... (subset figure in a box) Recognition of proteins containing CP2-binding motifs and verification of the CP2-binding ability of REST and YY1 that contain the HXPR motif As stated above, none of the 12-mer ... novel finding We also provide the first evidence that the HXPR motif mediates the binding of these two proteins to CP2 YY1 and REST mutants having substitutions of H to A or PR to AA on the HXPR...

Ngày tải lên: 16/03/2014, 18:20

... occur [10] However, further characterization of the D214A mutant was not conducted because of difficulties in removing PMII from the activation sample Removal of PMII from the sample, despite being ... a medium in the catalytic reaction The position of Lys78 is anchored with an interaction between the main chain oxygen of Ala216 and the e-amine of Lys78 In H34A mutant (Fig 6B), the interaction ... (Table 2) These results are consistent with the reported secondary structures of pepsin-like aspartic proteases which are predominately b sheet [16] On the basis of the kinetic behavior of the H34A...

Ngày tải lên: 23/03/2014, 07:20

... elements in the FasL promoter (A) Schematic representation of the deletions in the 5¢ terminus of the FasL promoter that were cloned upstream of a luciferase reporter gene The 3¢ end of the FasL ... may sub serve the role of such agents Recently, the physiological importance of NFAT in cells other than those of the immune system has been uncovered The widespread distribution of NFAT mRNA ... repression of NFAT and the pathophysiology of these diseases Given the importance of NFAT in fundamental physiology, the inhibition of NFAT function by retinoids may be a critical factor in NFATmediated...

Ngày tải lên: 24/03/2014, 03:21

... and 71 Considering the location of the N-terminal extremity of DNter2 on the structure of CARP and the presence of the potential cleavage sites, we identified the localization of the cleavage site ... analysis of CARP expression in the subcellular compartments Regulation of CARP by calpain obtained from the muscle of the mice injected with pYFP-CARP-CFP-HIS confirms the presence of the protein in the ... observed inside the nucleus However, it is possible that the loss of one NLS in the C-terminal fragment affects the nuclear transport of this form of CARP, although the sensitivity of the methods...

Ngày tải lên: 29/03/2014, 21:20

... results of the standard regression analysis showed that the set of the three variables of predictors of this model could explain 49.7% of the variance in the intention variable Because of the small ... variable in this model (table 5) Table 5: The results of the examination of Slope Hypothesis for the determination of the presence and the power of the presence of predictor variables in regression ... in the stock market by the people involved in this commerce The measurement tools for the identification of the effective factors in the selection or the decisions made for the application of...

Ngày tải lên: 13/07/2014, 21:13

... in normoxia The accumulation of the α-subunits allows for αβ heterodimer formation and translocation into the nucleus during hypoxia This process leads to selective upregulation of genes whose ... Hypoxia-inducible factor- 1α: role in hypoxaemia-initiated lung injury The master regulatory element of hypoxic conditions and adapting oxidative stresses to gene expression is HIF-1α [8–10] HIF-1 consists of ... science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated κ lung injury: role for nuclear factor- κB Crit Care 2002, 6:481490 10 11 12 13 Haddad JJ:...

Ngày tải lên: 12/08/2014, 19:21

... modification of the dominance relations of a melanotic tumor gene in Drosophila melanogaster Genet Res 20, 115-135 Bridges CB (1916) Non-disjunction as a proof of the chromosome theory of inheritance ... genetic factor causing melanotic tumours in the aged females is located on the second chromosome, as is explicitly shown in table I The genetic factor responsible for the development of female ... semi-dominant In other words, the degree of dominance (h) seems to be nearly 0.5 The present results confirm that the melanotic tumour development in the melanogaster is genetically controlled and the hereditary...

Ngày tải lên: 14/08/2014, 20:20

... studies of ATRP  The polymerization rate show first order respect to monomer  The polymerization rate decreased with the addition of CuBr2 and increased with the addition of Cu(0)  The effect of ... kinetic behavior Rp decreased with the addition of CuBr2 and increase with the addition of Cu(0) Keq = 9.37×10-7 Recommendations  Investigate the effect of the others factors on ATRP such as initiator,temperature, ... reaction time increased with the length of the alkyl group of monomers  The polymerization rate followed the order MA > n-BA > n-OA III Results & Discussion The effect of ligand on reaction time...

Ngày tải lên: 27/04/2015, 09:07

... care to the accuracy of the content and the fluency of technical speaking Normally, accuracy is the content of the talk or the conversation 25 and the fluency is the way students present their ... for further study are also mentioned in this chapter of the thesis The study ends with the “References” which lists all the materials and sources of the information used in the study and the “Appendix” ... all the methods that are used to conduct this paper The fourth chapter is the analysis of the data from the survey conducted by the objects of the paper In this chapter, the author works on the...

Ngày tải lên: 18/12/2013, 21:45

... O1: the degree of the participation before the experiment of Class A O2: the degree of the participation at the end of the experiment of Class A O3: the degree of the participation before the ... the title of the presentation, the purpose(s) of the presentation, the length of time he/she will take, the main parts or points he/she will cover, the visual aids he/she will use, the time the ... were the teachers of the two classes; the others were the researcher and another teacher of English who observed the two classes before and at the end of the experiment III.5 The experiment As...

Ngày tải lên: 29/01/2014, 14:35

... [9] The KIND domain in these proteins is localized to the N-terminal region, and their specific functional domains are located in the C-terminal region The C-lobe of protein kinases mediates the ... proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the KIND family of proteins, only KIND2 binds to MAP2 Pull-down assay (PD) of the endogenous MAP2 from cerebellar lysates of P21 ... that the core sequence critical for the specific MAP2 binding resides within the 32 residues (amino acids 456–487) of the v-KIND KIND2 domain To examine whether the MAP2 binding core site of v-KIND...

Ngày tải lên: 14/02/2014, 19:20

... levels in testes than ovaries The deep interest in Dmrt1 in the field of sex determination in fish came with the discovery of a dmrt1 homologue on the Y chromosome of the fish medaka (Oryzias latipes) ... gene is the product of a gene duplication of the autosomal dmrt1a gene and was designated dmrt1bY [8] or Dmy [9] It was shown to be the only functional gene in the whole Y-specific region of the sex ... studied in the context of gonadal induction and maintenance, illuminating its important function But what about the other dmrt genes? Table summarizes the expression pattern of these genes in fish during...

Ngày tải lên: 14/02/2014, 19:20

... statement of the relation of loans to the other principal items of the bank balance sheet The burden of Part Two is a consideration of the factors underlying and affecting the soundness of the contents ... obligations to the creditors of the bank The larger the capital, surplus or undivided profits, other things being equal, the less is the likelihood of loss to the creditors of the bank Or stating the same ... the growth of the note brokerage business, the establishment of the bank credit department, and the rise of the new business department and its effects on the quality of bank loans The work of...

Ngày tải lên: 15/02/2014, 01:20

... initiation of apoptosis through the mitochondrial pathway The key event in the mitochondrial pathway is the release of proapoptotic factors from the mitochondrial intermembrane space into the cytosol, ... release of cytochrome c and second mitochondria-derived activator of caspase (Smac ⁄ DIABLO) allows for the formation of the apoptosome, a complex that enables the activation of caspases within the ... constant amounts of rLuc–Itch and various amounts of either Bid–GFP of tBid–GFP The graph is a representative example of the saturation studies performed to provide evidence for a specific interaction...

Ngày tải lên: 16/02/2014, 09:20

... and identified them by MS [14] The association of these proteins with TIAR was further confirmed by co-immunoprecipitation assays in the presence of RNAse Interestingly, most of the identified proteins ... upon tethering of TTP to the same reporter mRNA These results indicate that ASF ⁄ SF2 is a potent repressing factor in the absence of competing factors It is worth noting that the deletion of the ... interactions The capacity of ASF ⁄ SF2 to down-regulate mRNA expression was further confirmed by artificial tethering of a reporter mRNA to the 3¢ UTR In this assay, the down-regulating activity of ASF...

Ngày tải lên: 16/02/2014, 15:20

... explaining the vast neuronal loss in the AD brain Further investigation of the increased neurotrophic activity of the AD brain revealed that it correlated with the loss of a specific neuroinhibitory factor, ... conditions [22] In the traumatically injured brain, however, the synthesis of MT1 and MT2, as well as the synthesis of GIF, are up-regulated by reactive astrocytes in the vicinity of the lesion [23] ... thoughts on the role of GIF in AD Since its discovery in 1991 as a factor that might be deficient in the AD brain, a number of studies have investigated the role of GIF in the pathogenesis of AD While...

Ngày tải lên: 16/02/2014, 15:20

... enhancement of the expression of the tumour suppressor gene p53 [5] Because of the important roles of KLF4 on the above three cell types, we postulated the novel effect of KLF4 in atherogenesis ... binding site The specificity of transcriptional activity of KLF4 on SR-BI promoter was further confirmed by another transcription factor, KLF2, as a control Discussion Fig Expressions of KLF4 and ... from the KLF4 anti-inflammatory effect Certainly, it should be confirmed by further investigations As for no obvious influence of oxLDL on the expression of KLF4, the potential reason may be the deficiency...

Ngày tải lên: 18/02/2014, 04:20

... development of the lens and maintenance of the olfactory epithelium [102] The first evidence for a developmental function of HSF4 was provided by population genetic studies where mutations of the Hsf4 ... form of HSF4 increases, while the levels of HSF1 and HSF2 are reduced [102] In the olfactory epithelium of 3–6-week-old mice, the expression profile of HSF1 remains constant However, a significant ... levels [90] The signi cance of functional HSF2 in the testis is demonstrated by the phenotype of HSF2 null mice, exhibiting reduced sizes of testis and epididymis, altered morphology of the seminiferous...

Ngày tải lên: 18/02/2014, 04:20