•no in health and disease a janus faced molecule

... posterior EMG activity during walking in health and disease Tibialis posterior EMG activity during walking in health and disease – schematic estimates for ensemble-averaged tracings adapted from ... and effective method of investigating tibialis posterior EMG during walking Tibialis posterior EMG in health and disease Current literature has characterised TP EMG during gait among normal and ... Ultrasound imaging facilitates real-time observation of the insertion and identification of the neurovascular bundle and anatomical variants A recent investigation of TP intramuscular electrode insertion,...

Ngày tải lên: 10/08/2014, 21:23

... Preterm Infants 1.6.4 70 Evidence for Normative Data in Stool Metabolites, Inflammation and Immunological Markers of Gut Health in Preterm Infants i) Variation in Stool Bacterial Metabolites in Healthy ... Meg and Graham, my brother Paul, sister in law Yan, and nephew Noah Andy and my daughters Kate and Zed: for everything; for without whom, this is all meaningless Alicia, Study Baby 59, at age ... microbiota has been implicated in protection against cardiovascular, inflammatory, allergic and malignant conditions in later life (Isolauri 2012) Conversely, adverse alterations in the microbiota may...

Ngày tải lên: 22/12/2014, 21:27

... X-linked agammaglobulinemia A clinical and molecular analysis Medicine (Baltimore) 75, 287–299 Plebani A, Soresina A, Rondelli R, Amato GM, Azzari C, Cardinale F, Cazzola G, Consolini R, De Mattia D, ... involved in ligand binding, presumably abolishing the interaction with signaling partners The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce protein ... kinases and disease A Hussain et al disease, in which TFKs are showing increasing importance, both as an underlying cause, but recently also as potential targets for new drugs The main emphasis...

Ngày tải lên: 14/02/2014, 18:20

... Chromosome Aneuploidies 123 Eliona Demaliaj, Albana Cerekja and Juan Piazze Chapter Human Male Meiosis and Sperm Aneuploidies 141 Mar a Vera, Vanessa Peinado, Nasser Al-Asmar, Jennifer Gruhn, Lorena Rodrigo, ... Roblick and Thomas Ried Chapter Aneuploidy and Intellectual Disability 107 Daisuke Fukushi, Seiji Mizuno, Kenichiro Yamada, Reiko Kimura, Yasukazu Yamada, Toshiyuki Kumagai and Nobuaki Wakamatsu Chapter ... chloroquine and 17-AAG [50] AICAR induces energy stress, leading to the activation of the AMP-activated protein kinase AMPK1, whereas 17AAG is a derivative of Geldanamycin, which inhibits the heat...

Ngày tải lên: 21/02/2014, 23:20

... L-glutamate + oxaloacetate « a- ketoglutarate + L-aspartate (catalyzed by the enzyme aspartate aminotransferase) which of course is also L-aspartate + a- ketoglutarate « oxaloacetate + L-glutamate and ... acids that undergo transamination and thus are unique among essential amino acids Together, the BCAAs, alanine, aspartate, and glutamate make up the pool of amino N that can move among amino acids ... of protein or amino acids and the balance of a particular parameter—usually N balance—is measured An adequate amount of dietary protein is that level of intake that will maintain a neutral or slightly...

Ngày tải lên: 06/03/2014, 05:21

... hemopexin-like domain (C domain) of human gelatinase A (matrix metalloproteinase-2) requires Ca2+ for fibronectin and heparin binding Binding properties of recombinant gelatinase A C domain to extracellular ... domain The two minimal domain MMPs and MMP-23 lack the HPX domain and, in the latter enzyme, this domain is replaced by a C-terminal cystein array (Ca) and an immunoglobulin-like (Ig) domain ... recognition and binding of natural inhibitors (TIMPs) Recent data indicate that subtype specific inhibitors may also lead to new treatment of acute and chronic in ammatory and vascular diseases [99]...

Ngày tải lên: 15/03/2014, 00:20

... preparations today maintain whole cells, partial or complete brain regions, and even a whole, perfused brain for hours and days, intact and functional These in vitro preparations deserve attention, ... glucose-containing media, lactate accumulated in the media (29) This lactate accumulation was initially rapid (50 µmol/g/h), and fell after some minutes, to about 25% of the initial rate of accumulation ... obtained in vitro and in vivo, mostly in the early and mid-1980s, impeded the acceptance of the hippocampal slice preparation as a valuable tool in the study of brain energy metabolism and brain...

Ngày tải lên: 15/03/2014, 19:20

... decorin in breast cancer Am J Pathol 173, 844–855 48 Shintani K, Matsumine A, Kusuzaki K, Morikawa J, Matsubara T, Wakabayashi T, Araki K, Satonaka H, Wakabayashi H, Lino T et al (2008) Decorin ... experimental diabetic nephropathy [57,58] and in a renal obstruction model with interstitial in ammation and fibrosis [55,57] In renal fibroblasts, decorin activates the mammalian target of rapamycin and ... lumican might contribute as a therapeutic agent to combat melanoma metastasis Lumican can interact with b1-containing integrin receptors and this signaling leads to inhibition of melanoma cell...

Ngày tải lên: 15/03/2014, 23:20

... occludens-domain-containing proteins such as syntenin, Ga-interacting protein (GAIP)-interacting C-terminus ⁄ synectin and calcium ⁄ calmodulin-associated serine kinase, since the C2 region contains a class II ... metzincin subgroups, for example the ADAM ⁄ adamlysins, including ADAM-17 (TACE) [27], ADAM-10 [28] and ADAM-12 [29], and the ADAMs with thrombospondin motifs (ADAMTS) including the aggrecanases ADAMTS4 ... Purushothaman A, Uyama T, Kobayashi F, Yamada S, Sugahara K, Rapraeger AC & Sanderson RD (2010) Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis...

Ngày tải lên: 15/03/2014, 23:20

... focusing on head and neck carcinoma and multiple myeloma as examples of solid and hematological malignancies Heparanase in head and neck carcinoma: signaling in motion Squamous cell carcinoma of ... elevated already at the early stages of human neoplasia In the colon, heparanase gene and protein are expressed already at the stage of adenoma [105], and during esophageal carcinogenesis heparanase ... 388–392 Theocharis AD, Skandalis SS, Tzanakakis GN & Karamanos NK (2010) Proteoglycans in health and adisease: novel roles for proteoglycan in malignancy and their pharmacological targeting FEBS J...

Ngày tải lên: 15/03/2014, 23:20

Ngày tải lên: 22/03/2014, 16:20

... wet-nurse, and has grown a fine healthy lad The second, a girl, was unfortunate in her nurse, she being of a strumous and unhealthy constitution, although to a casual observer bearing the appearance ... power of generating heat in warm-blooded animals is at its minimum at birth, and increases successively to adult age; young animals, instead of being warmer than adults, are generally a degree or ... child into a warm bath, and, with the common domestic remedies, a very serious attack may be warded off Again, in the commencement of a diarrhoea, a warm bath, and discontinuing the cause of the attack,...

Ngày tải lên: 23/03/2014, 02:20

... as a major preventable cause of human cancer Journal of International Medicine 2000;248:171-83 [68] Allavena P, Garlanda C, Borrello MG, Sica A, Mantovani A Pathways connecting inflammation and ... organs in an intact and active form Efficacy of lunasin against breast, colon, leukemia and prostate cancer using cell culture experiments and animal models have been revealed in the last decade ... combination acted as a single agent Anacardic acid is a natural compound found in the shell of the cashew nut It has been linked to anti-oxidative, anti-microbial, anti-inflammatory and anti-carcinogenic...

Ngày tải lên: 23/03/2014, 04:20

... Beer Andrea Pavsler and Stefano Buiatti Lager Beer Andrea Pavsler and Stefano Buiatti Traditional and Modern Japanese Beers: Methods of Production and Composition Masato Kawasaki and Shuso Sakuma ... Consumption in Teenagers in Brazzaville (Congo) Jean Robert Mabiala Babela, Alphonse Massamba, Senga Prosper and Rajaventhan Srirajaskanthan Personality Characteristics Associated with Drinking and Beverage ... Vanhoenacker and Pat Sandra Methods for Determining Biogenic Amines in Beer Anastasia Zotou and Zacharenia Loukou Beer and ESR Spin Trapping Kevin Huvaere and Mogens L Andersen Methods for Determining...

Ngày tải lên: 12/06/2014, 11:26

... Chromosome Aneuploidies 123 Eliona Demaliaj, Albana Cerekja and Juan Piazze Chapter Human Male Meiosis and Sperm Aneuploidies 141 Mar a Vera, Vanessa Peinado, Nasser Al-Asmar, Jennifer Gruhn, Lorena Rodrigo, ... Roblick and Thomas Ried Chapter Aneuploidy and Intellectual Disability 107 Daisuke Fukushi, Seiji Mizuno, Kenichiro Yamada, Reiko Kimura, Yasukazu Yamada, Toshiyuki Kumagai and Nobuaki Wakamatsu Chapter ... chloroquine and 17-AAG [50] AICAR induces energy stress, leading to the activation of the AMP-activated protein kinase AMPK1, whereas 17AAG is a derivative of Geldanamycin, which inhibits the heat...

Ngày tải lên: 28/06/2014, 14:20

... of an amino group from an amino acid to an a- ketoacid, thus generating a new amino acid and a new a- ketoacid: aspartate + oc-ketoglutarate + oxaloacetate + glutamate Similarly, kinases transfer ... the authors with invaluable feedback: William L Anderson, Suzanne E Barbour, Alakananda Basu, David G Bear, Edward J Behrman, Frank J Castora, Anca D Dobrian, Diane M Duffy, Venkat Gopalan, Maurice ... urea cycle are circular pathways In each case the pathway is initiated by addition of a small molecule to a key metabolic intermediate (oxaloacetate in the TCA cycle and ornithine in the urea...

Ngày tải lên: 06/07/2014, 15:19

... were generated from fecal samples of only 33 individuals from the USA or Japan [2,29,37] Advances in analytical approaches are Page of 12 only exacerbating this problem and in a separate analysis ... and transport and catabolism; MEP pathway for biosynthesis of DXP and IPP; β-glucuronidase activity induced Kurokawa et al (2007) [37] adults, children and unweaned infants (Japanese and Japanese ... experimental findings and the predominant phylogenetic data, and specific pathways and functional pathways highlighted by analysis from the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and...

Ngày tải lên: 11/08/2014, 12:21

... bridges and a short twostranded antiparallel ␤ sheet, with the carboxy-terminal subdomain additionally containing a short ␣ helix [30] VEGF-B167 also binds NRP1 via an NRP1/heparin-binding domain ... sequence in each is marked below in base-pairs Start (ATG) and stop (TAA, TAG, TGA) codons are marked, and the length of each encoded unprocessed polypeptide including the signal peptide (in amino-acid ... VEGF -A1 21 lacks exons and 7, and VEGF -A1 65 lacks exon (Table 2) Exon encodes a heparinbinding domain, while exons and encode a NRP1/heparin-binding domain; with the exception of VEGF -A1 21, all isoforms...

Ngày tải lên: 14/08/2014, 14:21

... the menstrual inflammatory cascade Biol Reprod 90, 14 (2014) 34 Sugino, N., Karube-Harada, A. , Taketani, T., Sakata, A & Nakamura, Y Withdrawal of ovarian steroids stimulates prostaglandin F2α production ... vesicles are present in human uterine lavage and aspirate56,157, and are released from both primary EECs56 and EEC lines157–159 Analysis of a murine endometrial miRNA (hsa-miR‑30d) showed that it was ... Bacteroides spp regulate certain mechanisms in the gut that are relevant to the endometrium, including epithelial-cell maturation and maintenance, mucosal-barrier reinforcement and interactions with...

Ngày tải lên: 05/12/2016, 23:15

... intervention and prevention methods and strategies n Enhance communication, innovation and research n Promote multidisciplinary interactions among basic scientists, clinicians and behavioral and social ... pioneering innovative techniques and approaches Areas of research include health effects of exposure to air pollutants, endotoxin, BPA, phthalates, lead and arsenic as related to birth defects, asthma, ... asthma, endocrine-mediated changes, brain development and behavior NIEHS/EPA Children’s Centers Program Goals n Promote and accelerate translation of basic research findings into applied intervention...

Ngày tải lên: 12/02/2014, 19:20