Burket’s ORAL MEDICINE 12th edition www.ajlobby.com FM.indd 11/10/14 1:18 AM www.ajlobby.com FM.indd 11/10/14 1:18 AM Burket’s ORAL MEDICINE 12th edition Michael Glick, DMD, FDS RCSEd William M Feagans Chair Dean and Professor of Oral Medicine School of Dental Medicine State University of New York University at Buffalo Buffalo, New York 2015 People’s Medical Publishing House—USA Shelton, Connecticut www.ajlobby.com FM.indd 11/10/14 1:18 AM People’s Medical Publishing House-USA Enterprise Drive, Suite 509 Shelton, CT 06484 Tel: 203-402-0646 Fax: 203-402-0854 E-mail: info@pmph-usa.com © 2015 PMPH-USA, LTD All rights reserved Without limiting the rights under copyright reserved above, no part of this publication may be reproduced, stored in or introduced into a retrieval system, or transmitted, in any form or by any means (electronic, mechanical, photocopying, recording, or otherwise), without the prior written permission of the publisher 14 15 16 17/JPBros/9 ISBN-13 978-1-60795-188-9 ISBN-10 1-60795-188-6 eISBN-13 978-1-60795-280-0 Printed in India by Jaypee Brothers Medical Publishers, Ltd Editor: Linda H Mehta; Copyeditor/Typesetter: diacriTech; Cover designer: Mary McKeon Library of Congress Cataloging-in-Publication Data Burket’s oral medicine / [edited by] Michael Glick 12th edition p ; cm Oral medicine Includes bibliographical references and index ISBN 978-1-60795-188-9—ISBN 1-60795-188-6—ISBN 978-1-60795-280-0 (eISBN) I Glick, Michael, editor II Title: Oral medicine [DNLM: Mouth Diseases Diagnosis, Oral—methods WU 140] RK308 617.5'22—dc23 2014032898 Sales and Distribution Canada Login Canada 300 Saulteaux Cr., Winnipeg, MB R3J 3T2 Phone: 1.800.665.1148 Fax: 1.800.665.0103 www.lb.ca Foreign Rights John Scott & Company International Publisher’s Agency P.O Box 878 Kimberton, PA 19442, USA Tel: 610-827-1640 Fax: 610-827-1671 rights@johnscottco.us United Kingdom, Europe, Middle East, Africa Eurospan Limited 3, Henrietta Street, Covent Garden, London WC2E 8LU, UK Within the UK: 0800 526830 Outside the UK: +44 (0)20 7845 0868 http://www.eurospanbookstore.com Singapore, Thailand, Philippines, Indonesia,Vietnam, Pacific Rim, Korea McGraw-Hill Education 60 Tuas Basin Link Singapore 638775 Tel: 65-6863-1580 Fax: 65-6862-3354 www.mheducation.com.sg Australia, New Zealand, Papua New Guinea, Fiji, Tonga, Solomon Islands, Cook Islands Woodslane Pty Limited 10 Apollo Street Warriewood NSW 2102 Australia Tel: 612-8445-2300 Fax: 612-9997-5850 www.woodsland.com.au India, Bangladesh, Pakistan, Sri Lanka, Malaysia Jaypee Brothers Medical Publishers (P) Ltd 4838, 24 Ansari Road, Darya Ganj New Delhi- 110002, India Phone: +91 11 23272143 Fax: +91 11 23276490 www.jaypeebrothers.com People’s Republic of China People’s Medical Publishing House International Trade Department No 19, Pan Jia Yuan Nan Li Chaoyang District Beijing 100021, P.R China Tel: 8610-67653342 Fax: 8610-67691034 www.pmph.com/en/ Notice: The authors and publisher have made every effort to ensure that the patient care recommended herein, including choice of drugs and drug dosages, is in accord with the accepted standard and practice at the time of publication However, since research and regulation constantly change clinical standards, the reader is urged to check the product information sheet included in the package of each drug, which includes recommended doses, warnings, and contraindications This is particularly important with new or infrequently used drugs Any treatment regimen, particularly one involving medication, involves inherent risk that must be weighed on a case-by-case basis against the benefits anticipated The reader is cautioned that the purpose of this book is to inform and enlighten; the information contained herein is not intended as, and should not be employed as, a substitute for individual diagnosis and treatment www.ajlobby.com FM.indd 11/10/14 1:18 AM DEDICATION In memory of my mother, Siv Glück, who encouraged me to be the best person I could be; and my friend and colleague Jonathan Ship, whose life sadly ended much too early For my father, Dan Glück, with love and appreciation www.ajlobby.com FM.indd 11/10/14 1:18 AM www.ajlobby.com FM.indd 11/10/14 1:18 AM Contents Contributors ix Preface xv Chapter Introduction to Oral Medicine and Oral Diagnosis: Evaluation of the Dental Patient Chapter Overview of Clinical Research 17 Chapter Pharmacotherapy 29 Chapter Ulcerative, Vesicular, and Bullous Lesions 57 Chapter Red and White Lesions of the Oral Mucosa 91 Chapter Pigmented Lesions of the Oral Mucosa 123 Chapter Benign Lesions of the Oral Cavity and the Jaws 147 Chapter Oral and Oropharyngeal Cancer 173 Chapter Oral Complications of Nonsurgical Cancer Therapies: Diagnosis and Treatment 201 Chapter 10 Salivary Gland Diseases 219 Chapter 11 Temporomandibular Disorders 263 Chapter 12 Orofacial Pain 309 Chapter 13 Common Headache Disorders 323 by Michael Glick, DMD, FDS RCSEd; Martin S Greenberg, DDS, FDS RCSEd; Mats Jontell, DDS, PhD, FDS RCSEd and Jonathan A Ship, DMD, FDS RCSEd by Jane C Atkinson, DDS; Dena Fischer, DDS, MSD, MS; Holli A Hamilton, MD, MPH and Mary A Cutting, MS, RAC by Mark Donaldson, BSP, PharmD; Jason H Goodchild, DMD and Mark J Wrobel, PharmD by Sook Bin Woo, DMD, MMSc, FDS RCSEd and Martin S Greenberg, DDS, FDS RCSEd by Mats Jontell, DDS, PhD, FDS RCSEd and Palle Holmstrup, DDS, PhD, DrOdont by Alfredo Aguirre, DDS, MS; Faizan Alawi, DDS and Jose Luis Tapia, DDS, MS by A Ross Kerr, DDS, MSD; K C Chan, DMD, MS, FRCD(C) and Joan A Phelan, DDS by Joel Epstein DMD, MSD, FRCD(C), FDS RCSEd and Sharon Elad, DMD, MSc by Douglas E Peterson, DMD, PhD, FDS RCSEd and Siri Beier Jensen, DDS, PhD by Leah M Bowers, DMD; Philip C Fox, DDS, FDS RCSEd and Michael T Brennan, DDS, MHS, FDS RCSEd by Richard Ohrbach, DDS, PhD; Bruce Blasberg, DMD, FRCD(C), FDS RCSEd and Martin S Greenberg, DDS, FDS RCSEd by Rafael Benoliel, BDS, LDS, RCS Eng; Sowmya Ananthan, BDS, DMD, MSD; Julyana Gomes Zagury, DMD, MSD; Junad Khan, BDS, MPH, PhD and Eli Eliav, DMD, MSc, PhD by Scott S De Rossi, DMD and J Ned Pruitt II, MD vii www.ajlobby.com FM.indd 11/10/14 1:18 AM viii ■ Contents Chapter 14 Diseases of the Respiratory Tract 335 Chapter 15 Diseases of the Cardiovascular System 363 Chapter 16 Diseases of the Gastrointestinal Tract 389 Chapter 17 Renal Disease 411 Chapter 18 Hematologic Diseases 435 Chapter 19 Bleeding and Clotting Disorders 463 Chapter 20 Immunologic Diseases 489 Chapter 21 Transplantation Medicine 521 Chapter 22 Infectious Diseases 543 Chapter 23 Disorders of the Endocrine System and Metabolism 563 Chapter 24 Neuromuscular Diseases 611 Chapter 25 Basic Principles of Human Genetics: A Primer for Oral Medicine 625 Chapter 26 Geriatric Oral Medicine 653 Chapter 27 Pediatric Oral Medicine 669 Chapter 28 Panoramic Image Interpretation 683 by Patrick Vannelli, MD; Frank A Scannapieco, DMD, PhD; Sandhya Desai, MD; Mark Lepore, MD; Robert Anolik, MD and Michael Glick, DMD, FDS RCSEd by Peter B Lockhart, DDS and Laszlo Littmann, MD by Michael A Siegel, DDS, MS, FDS RCSEd; Lynn W Solomon, DDS, MS and Lina M Mejia, DDS by Scott S De Rossi, DMD and Matthew J Diamond, DO, MS, FACP by Michaell A Huber, DDS and Vidya Sankar, DMD, MHS, FDS RCSEd by Joel J Napeñas, DDS, FDS RCSEd and Lauren L Patton, DDS, FDS RCSEd by Jane C Atkinson, DDS; Niki Moutsopoulos, DDS, PhD; Stanley R Pillemer, MD; Matin M Imanguli, MD, DDS and Stephen Challacombe, BDS, PhD, FDS RCSEd, FRCPath by Thomas P Sollecito, DMD, FDS RCSEd; Andres Pinto, DMD, MPH; Ali Naji, MD, PhD and David L Porter, MD by Michaell A Huber, DDS; Spencer W Redding, DDS, MEd; Vidya Sankar, DMD, MHS, FDS RCSEd and Sook-Bin Woo, DMD, FDS RCSEd by Mark Schifter, BDS, MDSc, (Oral Med), M SND, M Oral Med; RCSEd, FFD RCSI (Oral Med), FRACDS (Oral Med); Mark McLean, BMed, PhD, FRACP and Sunday O Akintoye, BDS, DDS, MS by Eric T Stoopler, DMD, FDS RCSEd, FDS RCSEng and David A Sirois, DMD, PhD by Harold C Slavkin, DDS; Mahvash Navazesh, DMD and Pragna Patel, PhD by Katharine Ciarrocca, DMD, MSEd and Nidhi Gulati, MD by Juan F Yepes, DDS, MD, MPH, MS, DrPH, FDS RCSEd by Ernest W N Lam, DMD, MSc, PhD, FRCD(C) Index 695 www.ajlobby.com FM.indd 11/10/14 1:18 AM Contributors Alfredo Aguirre, DDS, MS [6] School of Dental Medicine State University of New York University at Buffalo Buffalo, New York Bruce Blasberg, DMD, FRCD(C) [11] Professor Emeritus, Dentistry Faculty of Dentistry University of British Columbia Vancouver, British Columbia, Canada Sunday O Akintoye, BDS, DDS, MS [23] Associate Professor Department of Oral Medicine Director, Oral Medicine Research Program University of Pennsylvania School of Dental Medicine Philadelphia, Pennsylvania Leah M Bowers, DMD [10] Resident, Department of Oral Medicine Carolinas Medical Center Charlotte, North Carolina Faizan Alawi, DDS [6] Associate Professor of Pathology Director, Penn Oral Pathology Services University of Pennsylvania School of Dental Medicine Philadelphia, Pennsylvania Sowmya Ananthan, BDS, DMD, MSD [12] Clinical Assistant Professor Divisions of Temporomandibular Disorders and Orofacial Pain & Oral Medicine Rutgers School of Dental Medicine Newark, New Jersey Robert Anolik, MD [14] President and Director of Clinical Research Allergy and Asthma Specialists Blue Bell, Pennsylvania Jane C Atkinson, DDS [2, 20] Center for Clinical Research Division of Extramural Research National Institute of Dental and Craniofacial Research National Institutes of Health Bethesda, Maryland Rafael Benoliel, BDS, LDS RCSEng [12] Professor and Associate Dean for Research Department of Diagnostic Sciences Rutgers School of Dental School Rutgers State University of New Jersey Newark, New Jersey Michael T Brennan, DDS, MHS, FDS RCSEd [10] Professor and Director, Carolinas Medical Center Charlotte, North Carolina Stephen Challacombe, BDS, PhD, FDS RCSEd, FRCPath [20] Professor of Mucosal Immunology, Oral Microbiology and Oral Medicine Kings College London London, England K C Chan, DMD, MS, FRCD(C) [7] Clinical Assistant Professor of Oral and Maxillofacial Pathology, Radiology and Medicine New York University College of Dentistry New York, New York Katharine Ciarrocca, DMD, MSEd [26] Assistant Professor of Oral Medicine Georgia Regents University Augusta, Georgia Mary A Cutting, MS, RAC [2] Center for Clinical Research Division of Extramural Research National Institute of Dental and Craniofacial Research National Institutes of Health Bethesda, Maryland Scott S De Rossi, DMD [13, 17] Chairman, Diagnostic Sciences Department of Oral Health and Diagnostic Sciences Georgia Regents University Augusta, Georgia ix www.ajlobby.com FM.indd 11/10/14 1:18 AM ...Burket’s ORAL MEDICINE 12th edition www.ajlobby.com FM.indd 11/10/14 1:18 AM www.ajlobby.com FM.indd 11/10/14 1:18 AM Burket’s ORAL MEDICINE 12th edition Michael Glick, DMD,... practice, and the 12th edition of Burket’s Oral Medicine will be a resource to all health professionals In order to reflect changes in the reach of the discipline of oral medicine, the 12th edition of... of Oral Medicine Director, Oral Medicine Research Program University of Pennsylvania School of Dental Medicine Philadelphia, Pennsylvania Leah M Bowers, DMD [10] Resident, Department of Oral Medicine