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Cuốn sách này thực sự mang tính ‘ứng dụng’ và trình bày khoa học sinh học càng phù hợp về mặt lâm sàng càng tốt, với các phần riêng biệt trình bày chi tiết về ứng dụng lâm sàng có liên quan và đưa khoa học vào ngữ cảnh. Do đó, cuốn sách này hỗ trợ các phương pháp giảng dạy hiện đại trong đó sinh viên nghiên cứu một chủ đề dựa trên một tình huống lâm sàng. Hugh Devlin và Rebecca Craven đã trình bày phương pháp tiếp cận hệ thống bằng cách mô tả cách hoạt động của các cơ quan chính khác nhau, điều gì xảy ra với bệnh tật và điều này ảnh hưởng như thế nào đến việc điều trị nha khoa của bệnh nhân. Thay vì thảo luận các phần về dược học, mô học, dịch tễ học và sức khỏe cộng đồng, các chủ đề này được đan xen trong toàn bộ văn bản và được đề cập đến nơi việc sử dụng chúng có liên quan nhất. Ấn bản đầu tiên của cuốn sách này do cố giáo sư Crispian Scully biên tập và có các phần riêng biệt về sinh lý học, bệnh lý học, giải phẫu học và phần còn lại. Ấn bản thứ hai này tích hợp các chủ đề và tập trung chặt chẽ hơn vào mức độ liên quan lâm sàng của chúng để độc giả sẽ muốn bổ sung cách đọc cuốn sổ tay này từ các văn bản khác, đặc biệt là về giải phẫu chi tiết và sinh học tế bào. Cuốn sách này sẽ là nguồn tài liệu vô giá cho các sinh viên nha khoa và nha sĩ học tập để nâng cao trình độ sau khi tốt nghiệp.
www.pdflobby.com OXFORD MEDICAL PUBLICATIONS Oxford Handbook of Integrated Dental Biosciences www.pdflobby.com Published and forthcoming Oxford Handbooks Oxford Handbook for the Foundation Programme 4e Oxford Handbook of Acute Medicine 3e Oxford Handbook of Anaesthesia 4e Oxford Handbook of Applied Dental Sciences Oxford Handbook of Cardiology 2e Oxford Handbook of Clinical and Healthcare Research Oxford Handbook of Clinical and Laboratory Investigation 3e Oxford Handbook of Clinical Dentistry 6e Oxford Handbook of Clinical Diagnosis 3e Oxford Handbook of Clinical Examination and Practical Skills 2e Oxford Handbook of Clinical Haematology 4e Oxford Handbook of Clinical Immunology and Allergy 3e Oxford Handbook of Clinical Medicine—Mini Edition 9e Oxford Handbook of Clinical Medicine 10e Oxford Handbook of Clinical Pathology Oxford Handbook of Clinical Pharmacy 3e Oxford Handbook of Clinical Rehabilitation 2e Oxford Handbook of Clinical Specialties 10e Oxford Handbook of Clinical Surgery 4e Oxford Handbook of Complementary Medicine Oxford Handbook of Critical Care 3e Oxford Handbook of Dental Patient Care Oxford Handbook of Dialysis 4e Oxford Handbook of Emergency Medicine 4e Oxford Handbook of Endocrinology and Diabetes 3e Oxford Handbook of ENT and Head and Neck Surgery 2e Oxford Handbook of Epidemiology for Clinicians Oxford Handbook of Expedition and Wilderness Medicine 2e Oxford Handbook of Forensic Medicine Oxford Handbook of Gastroenterology & Hepatology 2e Oxford Handbook of General Practice 4e Oxford Handbook of Genetics Oxford Handbook of Genitourinary Medicine, HIV, and Sexual Health 2e Oxford Handbook of Geriatric Medicine 2e Oxford Handbook of Infectious Diseases and Microbiology 2e Oxford Handbook of Key Clinical Evidence 2e Oxford Handbook of Medical Dermatology 2e Oxford Handbook of Medical Imaging Oxford Handbook of Medical Sciences 2e Oxford Handbook of Medical Statistics Oxford Handbook of Neonatology 2e Oxford Handbook of Nephrology and Hypertension 2e Oxford Handbook of Neurology 2e Oxford Handbook of Nutrition and Dietetics 2e Oxford Handbook of Obstetrics and Gynaecology 3e Oxford Handbook of Occupational Health 2e Oxford Handbook of Oncology 3e Oxford Handbook of Operative Surgery 3e Oxford Handbook of Ophthalmology 3e Oxford Handbook of Oral and Maxillofacial Surgery Oxford Handbook of Orthopaedics and Trauma Oxford Handbook of Paediatrics 2e Oxford Handbook of Pain Management Oxford Handbook of Palliative Care 2e Oxford Handbook of Practical Drug Therapy 2e Oxford Handbook of Pre-Hospital Care Oxford Handbook of Psychiatry 3e Oxford Handbook of Public Health Practice 3e Oxford Handbook of Reproductive Medicine & Family Planning 2e Oxford Handbook of Respiratory Medicine 3e Oxford Handbook of Rheumatology 3e Oxford Handbook of Sport and Exercise Medicine 2e Handbook of Surgical Consent Oxford Handbook of Tropical Medicine 4e Oxford Handbook of Urology 3e www.pdflobby.com Oxford Handbook of Integrated Dental Biosciences Second Edition Professor Hugh Devlin Professor in Restorative Dentistry, University of Manchester, UK Dr Rebecca Craven Senior Lecturer in Dental Health, University of Manchester, UK www.pdflobby.com Great Clarendon Street, Oxford, OX2 6DP, United Kingdom Oxford University Press is a department of the University of Oxford It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide Oxford is a registered trade mark of Oxford University Press in the UK and in certain other countries © Oxford University Press 2018 The moral rights of the authors have been asserted First Edition published in 2002 Impression: 1 All rights reserved No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing of Oxford University Press, or as expressly permitted by law, by licence or under terms agreed with the appropriate reprographics rights organization Enquiries concerning reproduction outside the scope of the above should be sent to the Rights Department, Oxford University Press, at the address above You must not circulate this work in any other form and you must impose this same condition on any acquirer Published in the United States of America by Oxford University Press 198 Madison Avenue, New York, NY 10016, United States of America British Library Cataloguing in Publication Data Data available Library of Congress Control Number: 2017955323 ISBN 978–0–19–875978–2 Printed and bound in China by C&C Offset Printing Co., Ltd Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct Readers must therefore always check the product information and clinical procedures with the most up-to-date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations The authors and the publishers not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breast-feeding Links to third party websites are provided by Oxford in good faith and for information only Oxford disclaims any responsibility for the materials contained in any third party website referenced in this work www.pdflobby.com v Foreword Contemporary clinical teaching and learning in dentistry and other health professions now integrates the biosciences with clinical scenarios This Oxford Handbook of Applied Dental Sciences is, however, the first that provides a format to support this style of learning Hugh Devlin and Rebecca Craven have a vast experience of teaching and learning in dentistry and have been at the forefront of advances in this integration Understanding the relevance of the non-clinical science to the clinical practice that it underpins is now known to provide much more effective learning This integration enables deep learning It stimulates interest in the biosciences for the clinical learner and its application becomes more meaningful Hugh Devlin is a successful teaching and research enthusiast He has taught undergraduates and postgraduates at the University of Manchester for over 35 years and his depth and breadth of experience could not be more appropriate for the development of this book He is a respected clinical academic with over one hundred scientific publications many of which explore the link between basic dental science and their clinical application Hugh received the IADR Distinguished Scientist Award (2011) for Research in Prosthodontics and Implants Rebecca Craven worked in general dental practice and community and hospital dentistry before spending over 25 years in successful university research and teaching Rebecca, like Hugh, has vast experience in and a passion for teaching and learning and could not be better placed to produce this book Her studying for the award of ‘Fellowship in Dental Surgery’ required returning to bioscience study after several years of clinical practice and this sparked a lifelong passion to integrate the two disciplines Rebecca now leads postgraduate Masters programmes in both research and Dental Public Health, a discipline in which she is an NHS Consultant She also leads the first year of the undergraduate dental programme Integrating bioscience with clinical care and seeking to apply, appropriately, the best evidence, is at the heart of the University of Manchester Dentistry programmes and of this book This book is truly ‘applied’ and presents the bioscience as clinically relevant as possible, with a separate sections detailing the relevant clinical application and putting the science into context This book therefore supports contemporary methods of teaching where students study a subject based on a clinical scenario Hugh Devlin and Rebecca Craven have presented a ‘systems’ approach by describing how the different major organs work, what happens with disease, and how this affects the patient’s dental treatment Rather than discuss sections on pharmacology, histology, epidemiology, and public health, these subjects are woven throughout the text and referred to where their use is most relevant The first edition of this book was edited by the late Professor Crispian Scully and had separate sections on physiology, pathology, anatomy, and the www.pdflobby.com vi vi FOREWORD rest This second edition integrates the topics and focuses more closely on their clinical relevance so that readers will want to supplement their reading of this handbook from other texts, especially for detailed anatomy and cell biology This book will be an invaluable resource for dental students and dentists studying for higher qualifications after graduation Paul Coulthard BDS MFGDP(UK) MDS FDSRCS FDSRCS(OS) PhD Dean of the School of Dentistry at the University of Manchester and Professor of Oral and Maxillofacial Surgery www.pdflobby.com vii Preface Our aim is to provide a pocket book of bioscience which is tailored to the needs of dental students Our approach has been to provide knowledge that is relevant to clinical dental practice and is up-to-date We want clinicians to reflect on the biological principles and mechanisms, which we hope will encourage deep learning Science is essential to understand the signs and symptoms of any patient’s disease and the clinician-scientist will be able to offer clear explanations when proposing treatment options to a patient Most undergraduate programmes now include some early introduction to dentistry alongside biosciences, but until now that change has not been reflected in textbooks We aim is to bridge this gap and show directly the relevance of the biology to the clinician The previous handbook on this subject, the Oxford Handbook of Applied Dental Sciences, edited by the late Professor Crispian Scully, had separate sections on physiology, pathology, anatomy, and the rest This new handbook seeks to integrate the topics and focus more closely on their clinical relevance so readers will want to supplement their reading of this handbook from other texts, especially for detailed anatomy and cell biology The thirteen chapters lead the reader through the major body systems In most cases, a one page opening is a succinct summary of a topic, enriched by diagrams and illustrations The authors have many decades of experience in clinical dentistry and learning and teaching where we have aspired to an integrated and evidence- based approach The Oxford Handbook format is ideally suited to the dental undergraduate and has proved very popular and practical for students It is also hoped that clinicians who are seeking to revise their understanding of biosciences or are preparing for higher clinical examinations may find this a useful starting point Hugh Devlin Rebecca Craven 2017 www.pdflobby.com viii Acknowledgements The authors would like to acknowledge the help of Mr Daniel Wand at the University of Manchester who gave much assistance with many of the diagrams www.pdflobby.com ix Contents Symbols and abbreviations xi Oral cavity and gut 2 Temporomandibular joint and surrounding musculature Oral mucosa, saliva, and speech 4 Bone 5 Liver Kidneys and chronic renal disease 7 Diabetes The respiratory system Heart and blood supply 10 Blood 11 Immune system 12 Central nervous system 13 Endocrine system Index 305 www.pdflobby.com 39 65 85 111 133 149 169 187 207 231 257 287 ... 4e Oxford Handbook of Complementary Medicine Oxford Handbook of Critical Care 3e Oxford Handbook of Dental Patient Care Oxford Handbook of Dialysis 4e Oxford Handbook of Emergency Medicine 4e Oxford. .. 3e Oxford Handbook of Operative Surgery 3e Oxford Handbook of Ophthalmology 3e Oxford Handbook of Oral and Maxillofacial Surgery Oxford Handbook of Orthopaedics and Trauma Oxford Handbook of. .. 2e Oxford Handbook of Pain Management Oxford Handbook of Palliative Care 2e Oxford Handbook of Practical Drug Therapy 2e Oxford Handbook of Pre-Hospital Care Oxford Handbook of Psychiatry 3e Oxford