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NGHIEN cCru TONG HOP SAN PHAM NGl/NG TU CLIA GLUCOZAMINCLOHYDRAT V6l MOT SO HOP CHAT CHLTA NHOM AMINO Nguyen Thi Thanh Phong, Phan Quang Thai Khna Hoa hoc Tririmg DHSP - DHQG Ha Ngi I Ma dau Nu6e ta eo san lirong hai san noi chung vei san luiTng tom noi rieng dude danh bat hang nam rttt Ion, irdfc tmh thai khoang 3().0()() ta'n vo torn [2] Trong luong phe thai chi'ra mOt luimg ehitin dang kd Chung eo boat tfnh sinh hoe cao, mot cac dan xua't ciia chitin la chitozan da duoc nghien ciifii rat ky b nude cung nhu a tren the gidii [3], [4], song eon mot sd d&n xua't khae chua duoc d6 cap nhidu cac nghien curu Chinh vi vSy, bai chung toi mudn d6 cap den mot so san philm ngimg tu giua glucozaminclohydrat vdi thiosemicacbazit, axit glutiimie va cixit aspatie II Thirc nghiem Qua trinh tach chitin va chuySn glucozaminclohydrat da duoc ehiing toi dang eOng trinh [1] Phan ung ngung tu giua glucozaminclohydrat va mot so hop chat chura nhdm NH2 dirge thue hifin theo so d6 sau: a^on - f )i j-o r / '•" K N / 'NHCI n Dieu che san phrim ngimg tii giua glucozaminclohydrat va thiosemicacbaz.it (Glu - N - thi) Dun he thong cat (buy phan khoang 50 phiit hOn h(.tp gom 0,015 mol Glu, 0,01 mol thi va 20 ml nude cho den tao hdn hop dong nhat Lam lanh den nhiet phong rdi them vao 10ml ete Ket tiia dirge tach eo mau v;uig nhat, Ige lay kfi't tiia va lam kh6 san p h i n b nhifit thich hgp 196 n miu chtf sSn phin ngung tu giiia Glucozaminclohydrat v^ axit glutamic (Glu - N Glut) Cho vho he thtfng cit thuy phSn h6n hgp gSn 0,02 mol Glu \k 0,015 raoI.Glut v^ 20ml etanol 96° Dun h6n hgp cho dffn tao h6n hgp ddng nh^t (khoang 2h) Di yen & nhiet d6 ph6ng, cho 15 ml axeton Lkn lanh cho d^n k.6t tinh hoan toan Lgc rfra b ^ g c6n tuyft ddi, Uten khO s&n phim nhiet d6 thich hgp n.3 Di^u cM phiia ngung tii giua glucozaminclohydrat v^ axit aspatie (Glu - N - Asp.) CSch didu ch^ tuong tii nhu di^u ch^ Glu - N - Glut & tren III Ket qua va thao luan ///./ Thdo ludn vesutSng hgp cac sdnphdm ngUng tu itiing, I Mi>\ ^ il^c Uwijg oim Cik: fyau pItfCin «g»rng Uf C C s i g U»»it; t^u atti (on : '7^y tij«,> \ ),i,>is M / Jiiiti}; in 3(i j CliOt! j—(jll • A^ j l y n lutti i i'HOU I It a i iiitti 2t:* 'IH €11* Jit «i:i 1 Phdn dng ngung tu cd Vhk nSng xky theo giai doan dd la c6ng vJi t^ch DQ nhdm *NH3 hut electron manh diJng canh nhdm C = nhdm dd ^ tang dien tfch duong d cdcbon cabonyl di^u dd tao di^u kien thuan Igi cho nhdm NHj tSh cOng v^o C = Mat khdc phSn ting 197 duge thuc hien m5i trir^mg axit ycu nen phan ung cgng va tach deu thuAn Igi C^c san phim thu duge deu la nhung chat rdn, eo nhiet d6 phan huy kha cao Khi so sanh nhiet dd ndng chay ciia cac chat dau va cac san phdm, ta cd the nhan thay sir khae kha ro (bang 1), chung to cac phan ung xay theo du doan III.2 Bien lugn ve hong ngogi cua cac san phani ngimg tu Nhin chung phd hong ngoai ciia cac chat nghien cuu diu xu^t hien cac pie dac trung cho dao ddng hoa tri va dao dong bien dang cua cac nhdm chiJc phan tir chSft dau va cac san phdm (bang 2) Tren bang chung la d6 dang nhan thay ngoai cac pic dac trung cua Glu, xuat hien cac pie mdi dac trung cho dao dong hoa tri ciia nhdm iizometin Veh-n (1642 cm"') va dao dong bie'n dang cua lien ket C-H nhdm - CH = N- (5CH=N 997 - 950 em"') IV Ket luan Da thirc hien phan ung ngung tu giua glucozamin clohydrat vdi thiosemicacbazit, axit glutamic va axit aspatie Da nhan dang san pham dua tren phd dd IR va nhiet dd ndng chay, va nhan th^y cd kha nang xay phan ngung tu giira gluzamin clohydrat vdi mdt so hgp chaft ehiJa nhdm amino ki tren Tai lieu ihani kluio Nguyen Thi Thanh Phong, Phan Quang Thai, Nghien ciJii tach, ehuye'n hoa chitin axit glucozaminic va boat tfnh sinh hoc cua Fe (II) Glucozaminat, tuydn tap bao cao Hoi nghj Hoa hoc toan qudc Ian thii 3, tr 160-161, Ha Ngi 1998 Nguyen Ngge Tu, Bao cao khoa hoe tai Hdi nghi Vien Hoa hoc Ian thu" II, Ha Ndi, 22 thdng nam 1995 G A F Roberts and J G Domszy inl J Biol Macromol., 4.374 - 377, 1982 Rinaudo M.and Desbrieres, J Macromol Chem 182 373, 1981 SUMMARY We have investigation the condensation reactions of Glucosamine Chlohydratewith the Thiosemicarbazide, Glutamic and Aspatie acids The condensation products weredetenninated base on Infrared adsorption Spectra and molten pxjints 198 ... giira gluzamin clohydrat vdi mdt so hgp chaft ehiJa nhdm amino ki tren Tai lieu ihani kluio Nguyen Thi Thanh Phong, Phan Quang Thai, Nghien ciJii tach, ehuye'n hoa chitin axit glucozaminic va... b ^ g c6n tuyft ddi, Uten khO s&n phim nhiet d6 thich hgp n.3 Di^u cM phiia ngung tii giua glucozaminclohydrat v^ axit aspatie (Glu - N - Asp.) CSch didu ch^ tuong tii nhu di^u ch^ Glu - N - Glut... C-H nhdm - CH = N- (5CH=N 997 - 950 em"') IV Ket luan Da thirc hien phan ung ngung tu giua glucozamin clohydrat vdi thiosemicacbazit, axit glutamic va axit aspatie Da nhan dang san pham dua tren
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