Author(s): Maria Z. Siemionow (eds.) Publisher: SpringerVerlag London, Year: 2015 ISBN: 9781447163343,9781447163350 Description: There is a paradigm shift in plastic and reconstructive surgery from the interest of developing new surgical techniques into the application of new technologies via research based studies on stem cells, tissue engineering and new field of reconstructive transplantation such as e.g. face, hand or larynx transplants. This approach is relatively novel and introduced to plastic surgery within past decade. Thus there is an urgent need to facilitate access to this new knowledge which was not traditionally a part of plastic surgery curriculum. The most efficient way of introducing these new approaches is via presentation of pertinent to different fields (stem cell, transplantation, nerve regeneration, tissue engineering) experimental models which can be used as a tool to develop technologies of interest by different groups of surgeons. These surgical specialities which will be interested and benefit from the book include: plastic and reconstructive surgeons, microsurgeons, hand surgeons, orthopaedic surgeons, neurosurgeons and transplant surgeons.
Maria Z Siemionow Editor Plastic and Reconstructive Surgery Experimental Models and Research Designs 123 Plastic and Reconstructive Surgery Maria Z Siemionow Editor Plastic and Reconstructive Surgery Experimental Models and Research Designs Editor Maria Z Siemionow Department of Orthopaedics University of Illinois at Chicago Chicago, IL USA ISBN 978-1-4471-6334-3 ISBN 978-1-4471-6335-0 DOI 10.1007/978-1-4471-6335-0 Springer London Heidelberg New York Dordrecht (eBook) Library of Congress Control Number: 2014960234 © Springer-Verlag London 2015 This work is subject to copyright All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer Permissions for use may be obtained through RightsLink at the Copyright Clearance Center Violations are liable to prosecution under the respective Copyright Law The use of general descriptive names, registered names, trademarks, service marks, etc in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made The publisher makes no warranty, express or implied, with respect to the material contained herein Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) I dedicate this book to all my Fellows, residents, and students over the past 30 years who spent part of their education and life in my Microsurgery Laboratory and contributed to the most innovative research in microsurgery, microcirculation, and nerve regeneration and pioneering studies on vascularized composite allotransplantation Their enthusiasm, intelligence, and skills made significant impacts on the development of reconstructive surgery and research Maria Z Siemionow Preface It is a great privilege and pleasure to introduce the book Plastic and Reconstructive Surgery: Experimental Models and Research Designs The idea behind writing this book was to document over 30 years of my research interest in the fields of microsurgery, peripheral nerve surgery, and vascularized composite allotransplantation and to acknowledge the contribution of over 150 of my international trainees participating and contributing to the development of my research program I invited all my Fellows, residents, and students, who have made major contributions to my research, to write the chapters on experimental models and designs which were the subject of their fellowship and training during the time they spent in my Research Laboratories at the University of Utah, the Cleveland Clinic, and the University of Illinois at Chicago This generated enthusiastic response from 60 of my trainees and resulted in the delivery of 76 chapters, each on the different experimental model and design which represented their research work during the time they spent in my laboratories The book is unique since many experimental models and designs presented here are being introduced to the literature for the first time, and this is specifically true for the models of vascularized composite allotransplantation, such as face, larynx, vascularized bone, limb, abdominal wall, penis, and ovarian transplants The book content is divided into six sections describing different models and relevant experimental designs All chapters introduce unique experimental models which are relevant to the field of plastic and reconstructive surgery and vascularized composite allotransplantation research The sections include: Microsurgery Models, Microcirculation Models, Transplantation Models, Peripheral Nerve Surgery Models, Microsurgical Robot Applications, and Cellular Therapy Models For each of the experimental model designs, the technique of model application is presented as well as the research protocol which was tested by the particular experimental model The idea of bringing this book to the plastic and reconstructive surgery readership is to introduce an up-to-date comprehensive review of both standard and new techniques and technologies, such as face and hand transplantation or stem cell therapies, which were introduced in recent years The aim of the book is to provide a comprehensive review system which will help vii Preface viii residents and young surgeons to prepare for board exams as well as provide access to the comprehensive material of surgical research and design The book emphasizes innovations and new technologies as well as research approaches as applied to general plastic surgery, hand surgery, peripheral nerve surgery, microsurgery, reconstructive surgery, and reconstructive transplantation To the best of my knowledge, this is the first book of this kind, which in one volume presents a novel and most updated approach to the application of experimental models and designs to test clinically relevant questions Each chapter is well illustrated and provides an outline of the experimental design as well as descriptions of new surgical techniques with drawings, images, and references I hope this book will be of interest to young surgeons in training and those interested in research, since they will be able to get a quick comprehensive overview of new surgical techniques and technologies which will be applied in the near future to surgical practice and thus will help them decide on their area of specialization It has been a great pleasure to work once again with all my trainees, who have developed their own careers and become experts in the fields which they have outlined in the chapters of this book From the perspective of the many years which have passed, I am proud that my effort to teach them about the importance of research and science in our professional and everyday life has had an impact on both their lives and their career choices I also hope that this book will help a new generation of surgeon-scientists to make continued contributions to the new, developing fields of reconstructive surgery with the ultimate goal of helping patients by introducing new, minimally invasive, and safer surgical procedures Chicago, IL, USA Maria Z Siemionow, MD, PhD, DSc Contents Part I Microsurgery Models Microsurgical Techniques in Reconstructive Surgery Maria Z Siemionow and Fatih Zor Arterial and Venous Microanastomosis Models Maria Z Siemionow, Greg J Kwiecien, Safak Uygur, and Adam Bobkiewicz 11 Lymphaticovenous Anastomosis Training Model in Rat Ilker Yazici and Maria Z Siemionow 33 Fallopian Tube Anastomosis Greg J Kwiecien 39 Vasoepididymostomy Anastomosis Safak Uygur 45 The Microsurgical Groin Skin Flap in the Rat Model Raffi Gurunluoglu and Maria Z Siemionow 53 Free TRAM Flap Model Jerzy Jankau 63 Part II Microcirculation Models Application of Microcirculatory Models in Plastic Surgery Research: Review Krzysztof Kusza, Maria Z Siemionow, and Małgorzata Cyran 71 Standard Cremaster Muscle Model for Ischemia Reperfusion Michal Molski, Ilker Yazici, and Maria Z Siemionow 83 10 Cremaster Muscle and Effect of Different Anesthetics Mariusz Mielniczuk and Krzysztof Kusza 89 11 Microcirculatory Shock Model Jacek Szopinski and Krzysztof Kusza 97 12 Radiation and Microcirculation Models 103 M Sühan Ayhan and Hakan Bulam ix .. .Plastic and Reconstructive Surgery Maria Z Siemionow Editor Plastic and Reconstructive Surgery Experimental Models and Research Designs Editor Maria Z Siemionow Department... continuous horizontal mattress, interrupted M .Z Siemionow (ed .), Plastic and Reconstructive Surgery: Experimental Models and Research Designs, DOI 10.1007/978-1-4471-6335-0_2, © Springer- Verlag London. .. Part I Microsurgery Models Microsurgical Techniques in Reconstructive Surgery Maria Z Siemionow and Fatih Zor Arterial and Venous Microanastomosis Models Maria Z Siemionow,