A total synthesis of cyclodepsipeptide [Leu]6-aureobasidin K using combination of solid- and solution-phase

A total synthesis of cyclodepsipeptide [Leu]6-aureobasidin K using combination of solid- and solution-phase

A total synthesis of cyclodepsipeptide [Leu]6-aureobasidin K using combination of solid- and solution-phase Andi Rahima, Ace Tatang Hidayata,b, Nurlelasaria, Desi Harnetia, Unang Supratmana,b, and Rani Maharania,b,* a Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, Indonesia b Laboratorium Sentral, Universitas Padjadjaran, Jatinangor, West Java, Indonesia * Corresponding email : r.maharani@unpad.ac.id Figure S1 Spectrum FT-IR of (R)-2-hydroxy-3-methylbutanoic acid Figure S2 1H-NMR (500 MHz in CD3OD) of (R)-2-hydroxy-3-methylbutanoic acid Figure S3 Spectrum FT-IR of (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)oxy)-3-methylbutanoic acid O O OH O O Figure S4 1H-NMR (500 MHz in CDCl3) of (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)oxy)-3-methylbutanoic acid Figure S5 13C-NMR (125 MHz in CDCl3) (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)oxy)-3-methylbutanoic acid Figure S6 Analytical RP-HPLC chromatogram of [Leu]6-Aureobasidin K Conditions: Eluent Stationary phase Retention times : ACN:water (Gradient, 20-80%) 13 minutes λ 240 nm, v = mL/min : LiChrosper C-18, PDA detectores : 6.49 Figure S7 HR-TOF-MS-ES+ spectrum of [Leu]6-Aureobasidin K Calculated mass : 1093.6673 [C59H90N8O10 + Na+] Figure S8 1H-NMR (500 MHz in CD3OD) of [Leu]6-Aureobasidin K ... Figure S7 HR-TOF-MS-ES+ spectrum of [Leu]6-Aureobasidin K Calculated mass : 1093.6673 [C59H90N8O10 + Na+] Figure S8 1H-NMR (500 MHz in CD3OD) of [Leu]6-Aureobasidin K ... (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)oxy)-3-methylbutanoic acid Figure S5 13C-NMR (125 MHz in CDCl3) (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)oxy)-3-methylbutanoic acid Figure S6 Analytical RP-HPLC chromatogram of [Leu]6-Aureobasidin. .. [Leu]6-Aureobasidin K Conditions: Eluent Stationary phase Retention times : ACN:water (Gradient, 20-80%) 13 minutes λ 240 nm, v = mL/min : LiChrosper C-18, PDA detectores : 6.49 Figure S7 HR-TOF-MS-ES+