Hyperadiponectinemia is an indicator of worse outcomes in advanced heart failure (HF), its role in de novo HF is less clear. Objective: Because this protein is a hormone with starvation properties, we wanted to know its association with nutritional state and its regulator factors in de novo HF.
Int J Med Sci 2018, Vol 15 Ivyspring International Publisher 417 International Journal of Medical Sciences 2018; 15(5): 417-424 doi: 10.7150/ijms.22854 Research Paper Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients Rosa M Agra1,2,3, Ángel Fernández-Trasancos2, Esther Díaz-Rodríguez2, Alberto Cordero4, Alfonso Varela-Román1,2,3, Inés Gómez-Otero1,2,3, J Nicolás López- Canoa1, Ángel Luis Fernández3,5, José Manuel Martínez-Cereijo5, José Ramón González-Juanatey1,2,3, Sonia Eiras2,3 Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Spain Cardiology Group, Health Research Institute of Santiago de Compostela, Spain CIBERCV: Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares Cardiology Department, University Hospital of San Juan, Alicante, Spain Heart Surgery, University Clinical Hospital of Santiago de Compostela, Spain Corresponding author: Sonia Eiras Penas, Laboratorio IDIS Planta -2 C/Choupana s/n Complejo Hospitalario Universitario de Santiago de Compostela 15706 Santiago de Compostela (Spain) e-mail: sonia.eiras.penas@sergas.es; Tel:0034981955074 © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/) See http://ivyspring.com/terms for full terms and conditions Received: 2017.09.18; Accepted: 2017.11.23; Published: 2018.02.12 Abstract Background: Hyperadiponectinemia is an indicator of worse outcomes in advanced heart failure (HF), its role in de novo HF is less clear Objective: Because this protein is a hormone with starvation properties, we wanted to know its association with nutritional state and its regulator factors in de novo HF Methods: Adiponectin circulating levels were determined by ELISA at discharge in patients admitted for de novo HF (n=74) Nutritional status was determined by CONUT score Univariate and multivariate Cox regression analyses were employed to calculate the estimated hazard ratio (HR) with 95% confidence interval (CI) for death or all-cause readmission Stromal vascular cells (SVC) of EAT and subcutaneous adipose tissue (SAT) from patients (n=5) underwent heart surgery were induced to adipogenesis for 18 days Then, cells were cultured with complete or starved medium for hours At the end, adiponectin expression levels were analysed by real time polymerase chain reaction Results: Patients were grouped regarding nutritional status There was a strong association between high adiponectin levels and failing nutritional status Those patients with worse nutritional state had the highest adiponectin and proBNP levels at discharge (p