Applications of nanocurcumin in cancer treatment

NANO CURCUMIN TEAM Nguyen Thi Thanh Ngan Nguyen Bảo Ngoc Le Thi Thanh Trang CONTENTS Introduction Properties Applications of cancer treatment Why use nanosized of curcumin ? What is curcumin ?  Sources : the rhizomes of Curcuma longa  IUPAC’s name : (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta1,6-diene-3,5-dione  It has been widely used as coloring agent and spice in food, drugs, and cosmetics for centuries Structure s Properties P Physical B Biologycal activities of curcumin Orange-yellow crystalline powder Insoluble in water Very soluble in ethanol, acetic acid Physical properties 183 °C Biologycal activities of curcumin Anti-inflammatory Antioxidant Antiproliferative Antiangiogenic activities activities Molecular targets of curcumin Step : PLGA is sprayed into supercritical CO2, in which nanoparticles are formed by ultrasonic vibrations Step : PLGA-curcumin nanocapsules were obtained with an average size of 63 nm and 38% loaded, under ultrasonic power of 210 W, and with an average size of 40 nm and 36% of load, at an ultrasound capacity of 350 W > @ Nanotechnolog y Application of cancer treatment 800 reports have been published demonstrating the anticancer potential of curcumin GASTRIC CANCER THE NUMBERS 2nd 8th 69/100K *** IN THE WORLD IN THE USA IN JAPAN IN VIETNAM SYMPTOMS EXPERIMENTS Products Products References https://www.researchgate.net/profile/Indra_Bhatt/publication/235993633_Curcumin_Biological_and_medicinal_properties/links/56fa56c408ae7c1fda31a118/Curcumin-Biological-andmedicinal-properties.pdf https://daihocduochanoi.com/ung-thu-da-day-dich-te-va-giai-phau-benh/ https://sci-hub.tw/https://www.sciencedirect.com/science/article/pii/S0896844614000606 https://sci-hub.tw/https://www.sciencedirect.com/science/article/pii/S0378517312007958 https://sci-hub.tw/https://www.liebertpub.com/doi/abs/10.1089/1096620041224229 https://pubs.acs.org/doi/abs/10.1021/mp700113r https://pubchem.ncbi.nlm.nih.gov/compound/curcumin#section=Analytic-Laboratory-Methods ... Ngoc Le Thi Thanh Trang CONTENTS Introduction Properties Applications of cancer treatment Why use nanosized of curcumin ? What is curcumin ?  Sources : the rhizomes of Curcuma longa  IUPAC’s name... of 210 W, and with an average size of 40 nm and 36% of load, at an ultrasound capacity of 350 W > @ Nanotechnolog y Application of cancer treatment 800 reports have been published demonstrating... have been published demonstrating the anticancer potential of curcumin GASTRIC CANCER THE NUMBERS 2nd 8th 69/100K *** IN THE WORLD IN THE USA IN JAPAN IN VIETNAM SYMPTOMS EXPERIMENTS Products