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CATALYSIS AND APPLICATIONS Chapter – Basic concepts Dr Ngô Thanh An 1 Introduction Introduction 1 Introduction Introduction 1 Introduction Introduction Example 1 Introduction Introduction 2 Applications Applications 2 Applications Applications 2 Applications Applications 2 Applications Applications 2 Applications Applications 15 15 Enzyme Enzyme catalysis catalysis 15 15 Enzyme Enzyme catalysis catalysis 15 15 Enzyme Enzyme catalysis catalysis Simple Mechanisms • Chemical mechanism • Enzyme Catalyzed • How we measure kinetics experimentally? 15 15 Enzyme Enzyme catalysis catalysis Applying steady-state method d [ ES ] = k1[ S ][ E ] − k −1[ ES ] − k3 [ ES ] = dt Eo: Initial conc of enzyme E: conc at time t E = [E]o – [ES] [ E ]o [ ES ] = k +k + −1 k1[ S ] W= KM = k −1 + k k1 d [ P] [ E ]o [ E ]o [ S ] = k [ ES ] = k = k2 dt [S ] + K M 1+ KM [S ] Wmax = k [ E ]o W= Wmax [ S ] [S ] + K M 15 15 Enzyme Enzyme catalysis catalysis Wmax = k [ E ]o Wmax [ S ] W= [S ] + K M Wmax ½ Wmax 1 KM = + × W Wmax Wmax [ S ] Wmax is the maximum velocity [S] is the substrate concentration Km (Michaelis-Menten constant) is the substrate concentration at which the reaction velocity is the half of the maximum velocity 15 15 Enzyme Enzyme catalysis catalysis Enzyme inhibitor Competitive inhibitor 15 15 Enzyme Enzyme catalysis catalysis Noncompetitive inhibitor 15 15 Enzyme Enzyme catalysis catalysis Competitive inhibitor Non-competitive inhibitor 15 15 Enzyme Enzyme catalysis catalysis 15 15 Enzyme Enzyme catalysis catalysis 15 15 Enzyme Enzyme catalysis catalysis 15 15 Enzyme Enzyme catalysis catalysis 15 15 Enzyme Enzyme catalysis catalysis 15 15 Enzyme Enzyme catalysis catalysis 15 15 Enzyme Enzyme catalysis catalysis .. .1 Introduction Introduction 1 Introduction Introduction 1 Introduction Introduction Example 1 Introduction Introduction 2 Applications Applications 2 Applications Applications 2 Applications... Applications Applications 2 Applications Applications 2 Applications Applications 2 Applications Applications 2 Applications Applications 2 Applications Applications 3 Quiz Quiz 3 Quiz Quiz 3 Quiz... (