Lost causes are only really lost when you stop fighting for them tài liệu, giáo án, bài giảng , luận văn, luận án, đồ án...
Do you agree or disagree with the following statement? Playing a game is fun only when you win. Use specific reasons and examples to support your answer. Playing games is one of the most effective ways to eliminate stress, tension and to learn many things. However, I know some people who like to play only when they win. Personally, I agree with those people who play games in order not to win but to have fun. So, for several reasons, which I will mention bellow, I have to totally disagree with the statement above that playing a game is fun only for one who wins. First of all, I think that people should understand the main reason of playing a game. In old times people gathered and played different games. It was a great way to find out more about each other, to communicate and learn new. Nowadays, I think that the reason why people play games is the same. Second of all, in addition to the mentioned above benefit playing games is a perfect way to gain more knowledge and experience. It is not important who wins but it is important that everyone makes conclusions and learns to analyze one’s mistakes and tries to avoid them next time. Finally, mental and physical games help to develop brain and body. Mental games improve one’s ability to think logically, make conclusions and analyze. Also, it improves one’s memory. From the other side, physical games help to strengthen one’s bones, develop muscles and improve one’s health. Of cause, I must confess that it is fun to win and feel the victory. However, I think that the participation in a game is more important then the victory itself. People play games to relax, to eliminate stress and leave their troubles behind and gain more knowledge. One more reason why people play games is that avoiding games or playing them only when one is sure that he is a winner does not make one better. Only when people see their mistakes they can work on them and reach their goals. Lost causes are only really lost when you stop fighting for them Lost causes are only really lost when you stop fighting for them Bởi: Joe Tye “Lost causes are the ones most worth fighting for because they tend to be the most important, most humane ones They require us to live up to the best that is in us, to perfect ourselves and our world Lost causes cannot be won, but because they are so crucial to us, we nevertheless must try.” Richard Farson: Management of the Absurd In 1986 I was working fulltime as executive director of STAT (Stop Teenage Addiction to Tobacco), a nonprofit organization I’d founded to fight against unethical tobacco industry marketing practices, particularly those intended to influence children to become addicted to a product that would kill many of them I was on a cross-country flight working on the next edition of our Tobacco Free Youth Reporter when the person next to me lit a cigarette I politely asked if he would wait until the plane landed to smoke – he took a long drag, blew it in my face, and said no He smoked continuously for the rest of the flight – as did a significant number of other passengers I was sick as a dog by the time we landed – as were a significant number of other passengers And I almost gave up the fight If people were allowed to poison the air in the tightly-confined space of an airplane, what chance did we have for preventing the white collar drug pushers at cigarette companies from addicting successive generations of replacement smokers for those they’d killed off? When later that year Dr C Everett Koop (a true American hero) called for a smoke-free society, many people wondered what he’d been smoking It truly did appear to be a lost cause The changes that came about in succeeding decades were nothing short of miraculous Almost all public spaces are smoke-free, even in the heart of tobacco land; cigarette vending machines have been outlawed and tobacco products must be kept behind the 1/2 Lost causes are only really lost when you stop fighting for them counter; cigarette advertising has been banned from television, movies, and billboards, and the white collar drug pushers can no longer use characters like Camel Joe and the Marlboro Man to make smoking appear glamorous There are still far too many people smoking (almost all of whom eventually wish they could quit), far too many young people starting (many of whom will sicken and die as a result), and the tobacco industry has, in what can only be termed corporate evil at its worst, targeted third world countries as an expansion market It is still in some sense a lost cause – there is no hope that tobacco addiction will somehow just go away, or that tobacco industrialists will see the evil of their ways and stop, in the words of author Thomas Whiteside, selling death But it is still and always will be a cause worth fighting for When your world turns upside down, one of the first casualties is often the dreams you had for your future Dreams of going back to school, of writing your first novel or starting a business doing work you love to do, dreams of traveling the world or retiring to a cabin in the north woods Those dreams now seem like lost causes They might be – which is all the more reason why you should hang onto them tenaciously and fight for them ferociously 2/2 Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection Sandra Huerfano, Vojte ˇ ch Z ˇ ı ´ la, Evz ˇ en Bour ˇ a, Hana S ˇ panielova ´ , Jitka S ˇ tokrova ´ and Jitka Forstova ´ Department of Genetics and Microbiology, Faculty of Science, Charles University, Prague, Czech Republic Keywords apoptosis; minor proteins; mouse polyomavirus; VP2; VP3 Correspondence J. Forstova ´ , Department of Genetics and Microbiology, Charles University in Prague, Vinic ˇ na ´ 5, 128 44 Prague 2, Czech Republic Fax: +420 2 21951729 Tel: +420 2 21951730 E-mail: jitkaf@natur.cuni.cz (Received 4 November 2009, revised 15 December 2009, accepted 22 December 2009) doi:10.1111/j.1742-4658.2010.07558.x Minor structural proteins of mouse polyomavirus (MPyV) are essential for virus infection. To study their properties and possible contributions to cell death induction, fusion variants of these proteins, created by linking enhanced green fluorescent protein (EGFP) to their C- or N-termini, were prepared and tested in the absence of other MPyV gene products, namely the tumor antigens and the major capsid protein, VP1. The minor proteins linked to EGFP at their C-terminus (VP2–EGFP, VP3–EGFP) were found to dis- play properties similar to their nonfused, wild-type versions: they killed mouse 3T3 cells quickly when expressed individually. Carrying nuclear locali- zation signals at their common C-terminus, the minor capsid proteins were detected in the nucleus. However, a substantial subpopulation of both VP2 and VP3 proteins, as well as of the fusion proteins VP2–EGFP and VP3– EGFP, was detected in the cytoplasm, co-localizing with intracellular mem- branes. Truncated VP3 protein, composed of 103 C-terminal amino acids, exhibited reduced affinity for intracellular membranes and cytotoxicity. Biochemical studies proved each of the minor proteins to be a very potent inducer of apoptosis, which was dependent on caspase activation. Immuno- electron microscopy showed the minor proteins to be associated with damaged membranes of the endoplasmic reticulum, nuclear envelope and mitochondria as soon as 5 h post-transfection. Analysis of apoptotic markers and cell death kinetics in cells transfected with the wild-type MPyV genome and the genome mutated in both VP2 and VP3 translation start codons revealed that the minor proteins contribute moderately to apoptotic pro- cesses in the late phase of infection and both are dispensable for cell destruc- tion at the end of the virus replication cycle. Structured digital abstract l MINT-7386399, MINT-7386463, MINT-7386515: VP3 (uniprotkb:P03096-2) and GRP94 (uniprotkb: P08113) colocalize (MI:0403)byfluorescence microscopy (MI:0416) l MINT-7386328, MINT-7386434, MINT-7386493: VP2 (uniprotkb:P03096-1) and GRP94 (uniprotkb: P08113) colocalize (MI:0403)byfluorescence microscopy (MI:0416) l MINT-7386294, MINT-7386413, MINT-7386482: VP2 (uniprotkb:P03096-1) and Lamin-B (uniprotkb: P14733) colocalize (MI:0403)byfluorescence microscopy (MI:0416) l MINT-7386354, MINT-7386450, MINT-7386504: VP3 (uniprotkb:P12908-2) and Lamin-B (uniprotkb: P14733) colocalize (MI:0403)byfluorescence microscopy (MI:0416) Abbreviations CMV, cytomegalovirus; EGFP, enhanced green fluorescent protein; ER, endoplasmic reticulum; FACS, Creativity Thinking, Dr Ekaterina Khramkova, Russian Design Research Consultancy Lumiknows 24 April 2009, International Center for Innovation and Entrepreneurship Or the ability to connect to what is outside the box when you are inside it. Creativity Thinking Today: 1. What is Creativity; 2. Why is it that important for Innovation Entrepreneurs; 3. Why this is equal to “Design Thinking”. © 2009 Russian Design Research Consultancy Lumiknows 2 Kazimir Malevich, Black Square, c. 1915. State Russian Museum, St. Petersburg Abstract painting: An artistic revolution of the 20 th century. © 2009 Russian Design Research Consultancy Lumiknows 3 Do you know how the first abstract painting was created? © 2009 Russian Design Research Consultancy Lumiknows 4 Piet Mondrian, Composition with Yellow, Blue, and Red, 1937-42. Tate Gallery, London. Fernand Léger, The Railway Crossing, 1919. The Art Institute of Chicago Catherine de Zegher, Hendel Teicher (eds.). 3 X Abstraction. NY: The Drawing Center & /New Haven: Yale University Press. 2005. Jackson Pollock, Full Fathom Five, 1947. Museum of Modern Art, New York City Art clearly implied expression of ideas concerning the spiritual, the unconscious and the mind. © 2009 Russian Design Research Consultancy Lumiknows 5 Do you know how the first abstract painting was created? Wassily Kandinsky, Composition VII, 1913. The State Tretyakov Museum, Russia © 2009 Russian Design Research Consultancy Lumiknows 6 Pioneer spirit of an artistic revolution, The Times, June 3, 2006 One evening in the summer of 1909, Wassily Kandinsky became aware of the power of abstract art after he saw “indescribable beauty with an inner glow” in a painting. “I was startled momentarily, then quickly went up to this enigmatic painting in which I could see nothing but shapes and colours and the content of which was incomprehensible to me.” The answer to the riddle came immediately: it was one of his own pictures leaning upside down against the wall. But from then on, Kandinsky was bewitched by the idea that “subject matter was detrimental to my paintings”. © 2009 Russian Design Research Consultancy Lumiknows 7 The Nine Dot Puzzle © 2009 Russian Design Research Consultancy Lumiknows 8 The Nine Dot Puzzle © 2009 Russian Design Research Consultancy Lumiknows 9 The Nine Dot Puzzle © 2009 Russian Design Research Consultancy Lumiknows 10 [...]... Focus on what is already known; • “Nothing” behind what is seen; • Limited possibilities • Shift of focus to the “Big Picture”; • There is “Something” behind it, even if we don’t see this right now; • Abundance of possibilities © 2009 Russian Design Research Consultancy Lumiknows 17 How does it to do with the Innovation Entrepreneurship? Red Oceans are all the industries in existence today the known... structures limit their thinking To them, extra demand is out there, largely untapped Kim, Chan, Blue Ocean Strategy © 2009 Russian Design Research Consultancy Lumiknows 21 In order to get to the future first, there is no need to excel competitors trying to get the same prize because the number of prizes may be … … 1 1 5 5 s s e e c c r r e e t t s s y y o o u u m m u u s s t t k k n n o o w w w w h h e e n n y y o o u u a a r r e e a a r r o o u u n n d d w w o o m m e e n n … … "Body Language" An estimated 67% to 93% of human communication (according to university researchers) is non- verbal, and your body language reveals your internal emotional state. Whether someone's parents just died, or whether they just got promoted to CEO you can tell by observing their body language. So, as a man who tries to pick up and seduce women, you should be mindful of what you're communicating non-verbally. Body language consists of the following: - Your movements. They should be nonchalant, as if you're so fabulously successful that there's rarely a reason for you to rush nor try to impress anybody. Move through the world doing what you want and assuming that others will follow. - The displacement of your body. Your arms and legs should be spread out. Don't be afraid to take up space. - Your voice. It should have a calm, soothing, and commanding effect. Don't speak too fast or strain your voice. - Your face. Keep your facial muscles relaxed. Never tense your jaw, and only rarely should you frown or wrinkle your brow. - Your shoulders. Keep them relaxed like they'd be if you just got a massage. Don't raise them up like a nervous person. I would even go as far as to say that you body language is more important than anything you say, because if your body language doesn't match what you say, then you won't succeed with women. You see, if you tell a woman stories that convey your confidence, but at the same time you slump over and fold your arms, then you come across as fake. I've picked up women before merely through the use of my body language. For example, a couple months ago I was at a coffee shop that I frequent, lounging on the couch, arms spread out, with my feet up on the table. The mindset I had was that I felt so comfortable that it was as if I were in my home lounging on my own couch. It was as if I owned the coffee shop. The net result was that a girl sitting near me put down her book and started engaging me in random small talk. (Whenever an attractive girl you don't know starts a random conversation with you, you should ALWAYS assume that she's attracted to you. This is because women generally won't risk the whole male-female dynamic, especially with a stranger, unless they feel attraction.) The conversation went on for awhile, I got her number, called her that night, and a few days later we met and after several hours went to her place, where I spent the night. (We finally had sex in the morning.) The bottom line though is that she became initially attracted to me and approached me because of my body language. Now, of course body language isn't enough. You also must have an internal alpha male mindset that's consistent with your body language. But make no mistake about it if your body language conveys confidence, then your mood will also shift to become more confident. And have you ever noticed how when you walk with a spring in your step, you feel more upbeat? Conversely, when you cast your eyes down and drag your feet, you feel depressed. So your mindset also follows the body language that you adopt. So, in conclusion, be an alpha male with your mindset and your body language. Be in a woman's personal space and be sexual and interested in her, but at the same time don't be needy or desperate for her attention. Just be comfortable and enjoy yourself. And when your body language conveys that, it means Fill in the gaps with the following words: I know I can be a little …………………… sometimes (I say) A little righteous and too …………………… I just wanna find a way to …………………… Cause I believe we can work things out I thought that I had all the ……………………… never givin in but baby since you've ……………………… I admit I was ……………………… All I know is I'm lost without you I'm not gonna …………………… how am I gonna be strong without you I need you by my ……………………… if we ever said we'd never be together and we ended with ………………………… dunno what I'd I’m lost without you I keep trying to find my ………………… and all I know is I’m lost without you I keep trying to …………………… the day I'm lost without you How am I ever gonna get rid of these ……………………… baby I'm so lonely all the time everywhere I go I get so …………………………… you’re the only thing that’s on my mind On my bed so cold at …………………………… I miss you more each day only you can make it ………………………… no I'm not too proud to say All I know is I'm lost without you I'm not gonna …………………… how am I gonna be strong without you I need you by my …………………………… if we ever said we'd never be together and we ended with …………………………… dunno what I'd I'm lost without you I keep trying to find my …………………………… and all I know is I'm lost without you I keep trying to ………………………… the day I'm lost without you If I could only hold you now make the ……………………….just go away can't stop the tears from ………………………down my face (ho) All I know is I'm lost without you I'm not gonna ………………………… how am I gonna be strong without you I need you by my …………………………… if we ever said we'd never be together and we ended with …………………………… dunno what I'd I'm lost without you I keep trying to find my ……………………… and all I know is I’m lost without you I keep trying to ………………………… the day an all I know is I'm lost without your love I keep trying to find my ………………………… and all I know is I'm lost without you (ho) I'm lost without you answers blues compromise confused face gone goodbye lie night pain proud right running side stubborn way wrong Vocabulary definitions get rid of-(pv) - Give or throw away, sell or destroy something admit-(v) - Confess; say that one is responsible for something confused-(adj) - unable to understand something or think clearly about it compromise-(v) - To reach an agreement by giving up some demands face-(v) - To meet a challenge Vocabulary exercise He wanted French food, she wanted Spanish, so they and ate Italian People _ many difficulties when they move to another country I’m still a little about what happened I bought a new television set so I had to _ the old one The boy _ he broke the window Comprehension Questions What situation is the woman in? Who does she blame for it? Why? How does she feel now? Answer Key Delta Goodrem - Lost Without You I know I can be a little stubborn sometimes (I say) A little righteous and too proud I just wanna find a way to compromise Cause I believe we can work things out I thought that I had all the answers never givin in but baby since you've gone I admit I was wrong All I know is I'm lost without you I'm not gonna lie how am I gonna be strong without you I need you by my side if we ever said we'd never be together and we ended with goodbye dunno what I'd I’m lost without you I keep trying to find my way and all I know is I’m lost without you I keep trying to face the day I'm lost without you How am I ever gonna get rid of these blues baby I'm so lonely all the time everywhere I go I get so confused you’re the only thing that’s on my mind On my bed so cold at night I miss you more each day only you can make it right no I'm not too proud to say All I know is I'm lost without you I'm not gonna lie how am I gonna be strong without you I need you by my side if we ever said we'd never be together and we ended with goodbye dunno what I'd I'm lost without you I keep trying to find my way and all I know is I'm lost without you I keep trying to face the day I'm lost without you .. .Lost causes are only really lost when you stop fighting for them counter; cigarette advertising has been banned from television, movies,... north woods Those dreams now seem like lost causes They might be – which is all the more reason why you should hang onto them tenaciously and fight for them ferociously 2/2 ... first casualties is often the dreams you had for your future Dreams of going back to school, of writing your first novel or starting a business doing work you love to do, dreams of traveling the