phụ lục về khai thác luật kết hợp trong cơ sở dữ liệu tp. Hồ Chí Minh
Trang 1PIDJ LVC Al KHAITHACLUATKETHOP
Trang 6PHV LT)C A2
TIM CA C LUAT PHAN Lap TRONG CSDL NHAN KHA U
Ke't lu~n: thuQc tinh tInh tr~ng lao dQng
******** TIM LUAT KET HOP TV TAP rHO BIEN
Trang 9R31:*Can bo tho ky, tro ly, giao dieh, tiep thi, quang eao, gioi thieu san pham
~ >ehua eo vice lam
Trang 12PHV LT)C Bl TRINH TV SINH H <)C
Tdnh tl! sinh hQcADN la mQt chu6i Icyt1ldu'(1cca'u thanh t1lmQtky t1lcd so
(base) la 4 nucleotide: ademine (A); guaanine(G); thymine (T), cytosine (C).
Gen la mQt chu6i con cua S(1iADN va Ia ban thie't ke' cho cae protein Protein
dong vai tro cmnh ye'u trong ca'u trUc te' bflO, quye't dinh co che'di€u boa va
chilc nang cua te' baa MQtbQ gen cua mQt co ph?n la mQt t?P dfty dti c.ic ADN tlm tha'y trong co ph?n do BQgen ngu'oi co khoang 6 ti nucleotide ( 3 ti C?Pky tlf co so) va tii 30-50 ngan gen.
0,5 % cae nhi~m si\c th~ chua 3000 gen
~
MQt gen co chua 10"5 cae c~p nucleotide
Vung di~u hoa
Hinh Bi.] T6 chuc cua gen trong mQtte'bao lieu bi~u
Ba ti C?P ky co so cua bQ"gen ngu'oi du'(1ct6 chilc thanh cac don vi dQcI?p co
th~ nhln tha'y dU'<Jc qua kinh hi~n vi di~n tit Cac don vi nay du'<JcgQila nhi~m
Nhan cua phftn IOn cac te' biw ngu'oi chila 23 nhi~m s~c th~: 22 autosome va mQt nhi~m s~c th~ v€ gioi nnh M6i nhi~m s~c th~ co chung 150 tri~u ky t11cd
Trang 13Cae gen ngu'ai co chi~u d~lithay d6i, thu'ang md rQngdln hang ngan ky tlf cd
sd, nhu'ng chi chung 10% bi) gen ngu'oila co chila tdnh tt! ma hoa protein(vung exon) eua gen Xen ke trong nhi~u gen la cae vung intron khong co chile nang
ma boa Ta't ea cac cd ph~n SO-fig baa g6m phftn IOncae protein Con ngu'ai co th€ t6ng h<;1p it nha't la 100.000 IOC;li khae nhau Protein la cae phan til' IOnva phlie tC;lPdu'<;1C tC;lo I~p tu cae acid aminoCo 20 acid amin,m6i acid amin ling vdi
acid amin methionine Ma di truy~n la mQt day cae codon xac djnh cae acid amin eftn thie't d€ tC;loDen cae protein xac djnh.
trong blah B 1.2, bu'oe dftu tieD trong bi€u hi~n gen la phien ma, ml,1edich la dung ADN lam khuon dC;lngd€ t6ng h<;1pphan tit ARN Chi cae vung ma hoa trong tdnh tl! ADN co ehlia thong tin di truy~n Cae vung khac, du'<;1egQi Ia
I,
dftu eua vung ma boa Tie'n trlnh phien ma tU ADN sang ARN du'<Jcthl,l'chi~n
b~ng enzyme ARNpolymerase No b~t dftusail khi g~nno vao Promoter.
Tie'n tdnh dich ma dung s<;1i ARN lam khuon dC;lng d€ tang h<Jpphan ny Protein.
ARN du'<;1edung theo each nay du'<;1egQi la ARN mang tin (messager) MQt phan tit phile tC;lPdu'<;1egQi la ribosome se dQc mQt s<JimARN va dung tung chu6i g6m 3 nucleotides li€n nhau tromg mARN d€ ma hoa mi)t acid amin duy
nha't Cae bQ ba nay la cae codon va tie'n tdnh anh x~ tit codon sang acid amiD
Ia ma hoa thong tin di truy€n M6i gen chila cae doC;ln xen ke nhau cac intron
va exon.
Trang 14ADN:
T~o mARN mARN
I Exon 1 I Exon2 I Exon3 I Exon4 I &005 I
Dich ma mARN Protein
Innh B1.2: Con dttong tit ADNdtn protein
-Cae khung dQc lien quail dtn cach nhom cac nucleotides trong trinh 111ADN
thanh eae bQ ba tttdng t1!nhu' khi (ijch ma gen .
MQt s6 trinh tv nucleotide bi lo~i khoi trinh 111mARN tru'dc khi dich ma thanh protein Do v~y cac gen ehua cac do~n exon xeD ke nhau eon intron thi b~ loC:.li
bo Cae vung intron co chi~u dai tit 100 d€n 1000 nucleotide Cae ditim bien
nam gill' vung intron vA exon tren S\!i mARN dl!<jc gQi IA m6i noi
regIOn
Trang 15PHT) LT)C B2
E-COLI PROMOTER B2.1 Gioi thi~u
E-coli Ia Ioai vi khu~n gay fa b~nh dich ta Cac dti' li~u du'<Jckhao sat trong Iu?n an Ia dti' Ii~u E-Coli promoter do Jude ShavIik cung cap va d~ tren WebSite htt{J:/Iwww.ics.uci.edu.Cac dti' Ii~u nay chia lam hai nh6m cQng (nh6m E-Coli Promoter) va nh6m tru ( khong phai nh6m E-Coli Promoter).
Trang 16+
Trang 17B3.2 Dii'Ii~u khu§n Onchocerca
Ngu6n: WebSite NCBI(The National Center for Biotechnology Information) http://www.ncbi.nlm.nil.gov/
OVUO2802
AATTTTCAAAATTGCCTAATAACTGATGACCTATGACCCTAATCTCAA!I~~GCCCTACATACNrTCGAATTGGGTCC TAAGAAAAATATTCGACCATATTTAGG
OVUO2803
AGTTTGCAA!lATTA.~TT;'ACAACTGACGACCTATGATCCCTAATTTCAAGAAACGGGTACATACCTTCAAATTGAGTG CTAA.~~ATTCGACTATATTTTGG
OVUO2804
AATTTTCAA!lATTGCCTAATAACTGATGACCTATGACCCTAATCTCAAAftAACGGGTACATACATTCGAACCGGGTCC TAAGAAAAATATTCGACCATATTTAGG
OVUO280S
AGTTTGCAAAATTA.~TCAATAACTGATTACCTATGATTCCTAATTTCAAGAAGCGGATATGTACCGTCAAATTGAGTG CTlI.AAAAAAATATTCGACTATATTTTAT
Trang 18OVUO2814
AGTTTGCAATACTAATT~ATAACTGATGACCTTTGACCCCTAATTTCAAAAAACGGGTACGTACCTTCAAATTGAGTC CTAAAATAAATATTCGACTATATCTTGG
OVUO2815
AGTTTGCAAAATTAATT~ATAACTGGTGACATTTGACCCCTGATTTCACGAAAGGGGTACGTGCTTTCAAATTGAGTC CTAAAAAAAATATTCGACTATATTTGGT
OVUO2816
AGTTTGCATAATTAATTAAT.~CTGATGACCTATGATCCCTAATTTCCAAAAACGGGAACGTACCCTCAAATTTAGTC CTGAAAAAAATATTCGATTATATTTTAA
OVUO2817
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAAAAAACGGGTACGTACCTTCAAACTGGGTC CTAAGAAAAATATTCGACTATATTTTTT
OVUO2818
AGTTTTCAAAATTGCCTk~TAACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TAAG~ATATTCGACCATATTTTGG
OVUO2819
AGTTTTCAAAATTGCCTAATAACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TAAGAAAAATATTCGACCGTATTTTGG
OVUO2820
ATTTTGCAAAATTGATTATT_~CAGACGACCTATGACATATAATTTCAAAAAACGGGTACGTACCTTCAAACTGGGTC CTAAGAAAAATATTGCACTATATTTTTT
OVUO2821
AGTTTTCAAAATTGCCT~ATAACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TTAG~~TATTCGACCATATTTTGG
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAAAAAACGGGTACGTACCTTCAAACTGAGTC CT~AAAGTTTTCGACTATATTTTTT
OVUO2827
AATTTTCAAAATTGCCTAATAACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TAAGAAAAATATTCGACCATATTTTGG
OVUO2828
ATTTTGC~ATTGATTATTAACAGATGACCTATGACATATAATTTCAAAAAACGGGTACGTACCTTCAAACTGAGTC CTAAAAAAAGTTTTCGACTATATTTTTT
OVUO2829
AATTTTCAAAATTGCCTAAT~ACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACGTACCTTCAAACAGGGTCC TAAGAAAAATATTCGACTATATTTTTT
OVUO2830
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAAAAAACGGGTACGTACCTTCAAACTGGGTC CTAAGAAGAAGATTCGACCATATTTTAA
OVUO2831
ATTTTGCAAAATTGATTATTAACAGATGACCTACGACATATAATTTC~AACGGGTACGTACCTTCAAACTGGGTG CTAAGAAAAATATTCGACTATATTTTTT
OVUO2832
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCPAAAAACGGGTACGTACCTTCAAACTGGGTC CTAAGAAAAATATTCGACTATATTTTTT
OVUO2833
GTTTTGC~ATTGATTATT~ACAGATGACCTATGACATATAATTTCAP-~CGGGTACGTACCTTCAAACTGAGTCCTAPAAAAAGTTTTCGACTATATTTTTT
OVUO2834
CTAAGP~~~TATTCGACTATATTTTTT
GTTTTGCAAAATTGATTATT~ACA~~TGACCTATGACATATAATTTCk~CGGGTACG:ACCTTCAAACTGGGT'-OVUO2835
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAP~AAACGGGTACGTACCTTCAAACTGAGTC
CTAAAk~GTTTTCGACTATATTTTTT
Trang 19OVUO2836
AATTTTCAAAATTGCCTAATAACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TAAGAAAAATATTCGACCATATTTAGG
OVUO2840
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAAAAAACGGGTACGTACCTTCAAACTGAGTC CTAAAAAAAGTTTTCGACTATATTTTTT
OVUO2841
AATTTTCAAAATTGCCTAATAACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TAAGAAAAATATTCGACCATATTTTGG
OVUO2844
AATTTTCAAAATTGCCTAATAACTGATGACCTA~GACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TAAGAAAAATATTCGACCATATTTTGG
'-AGTTTTCAAAATTGCCTAATAACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TTAGAAAAATATTCGACCATATTTTGG
OVUO2846
AGTTTGCAAAATTAATTAACAACTGATGACCTATAACCCCTAATTTCJlACAAACGGGTACATACCTTCAAATTGAGTG CTAAAAAAAATGTTCGACTATATTTTCT
OVUO2847
AGTTTTCAAAATTGCCTAATAACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TAAGAAAAATATTCGACCATATTTTTG
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAAAAJlACGGGTACGTACCTTCAAACTGGGTC CTAAGAAAAATATTCGACTATATTTTTT
OVUO2849
AGTTTGCAAAATTGACTAATAACTGATGAGCTATGACCCCTAATTTCAAAAAACGCTAACGTACCTTCAAACTGAGTC CTAAAAAAAGTTTTCGACTATATTTTCT
OVUO2850
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAAAAAACGGGTACGTACCTTCAAACTGGGTC CTAAGAAAAATATTCGACTATATTTTTT
OVUO2851
ATTTTGCAAAATTGATTATTAACAGATCACCTATGACATATAATTTCAAAAAACGGGTACGTACCTTCAAACTGGGTC CTAAGAAAAAGATTCGACCATATTTTGG
OVUO2852
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAAAAAACGGGTACGTACCTTCAAATTGAGTC CTAAGAAAAATATTCGACTATATTTTTT
OVUO2853
AGTTTTCAAAATTGCTTAATAACTGATGACCTATGACCCTAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TAAGAAAAATATTCGACCATATTTTGG
OVUO2854
AGTTTTCAAAATTGCCTAATAACTGATGACCTACGATCTCAATCTCAAAAAACGGGTACATACATTCGAATTGGGTCC TAAGAAAAATATTCGACCATATTTTGG
OVUO2855
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAllJl.AAACGGGTACGTACCTTCAAACTGGGTC CTAAGAAAAATGTTCGACTATATTTTTT
OVUO2856
ATTTTGCAAAATTGATTATTAACAGATGACCTATGACATATAATTTCAll_~CGGGTACGTACCTTC.AAATTGAGTC CTAAGAAAAATATTCGACTATATTTTTT
OVUO2857
AGTTTCGAAAATTAATCAA TAACTGF.TTACCT ATGATTCCT AATTTCAAGAAGC GGATATGT ACCGTCAAATTGAGTG
CTAAAAAAAATATTCGACTATATTTTGG
Trang 20OVUO2858
AGTTTTCAAAATTCGTTAATAACTGATGACCTATGACCCTAATCTTAAAAAACACACATTCGA~TTGGGTCCTAAGAF.AAATATTCGACCATATTTTGG
Trang 21PHV LT,JC B4
DANHSACH CAC DO~N L~P PRO BIEN TRONG
53 TRINH TV SINH HQC E-COLI PROMOTER
NgliOng ph6 bie'n: 6/53
GGG,AACA,AACG,AATC,AAGC,AAGT,AAGG,ACAC,ACAG, ACCC, ACCT,
ACTG, ACGA, ACGT, ATAG, ATCA, ATCC, ATCT, ATTC, ATTG, ATGA, ATGT, ATGG, AGAG, AGCC, AGCT, AGTA,AGTC, AGTT, AGTG,AGGC, AGGT,CAAC, CAAT, CAAG, CACC,CACG, CATT,CATG,CAGC,CAGT CAGG,CCAA, CCAC,
CCAT,CCAG ,CCCA, ccCC,CCCG,CCTC, CCTT,CCGC,CCGT,CCGG, CTAC,CTAG, CTCC, CTCG,CTTC,CTGC, CTGT,CGAA,CGAC, CGCG,CGTA,CGTC, CGTG, CGGA, CGGC, CGGT,TATC, TAGT,TAGG,TCAA,TCAT,TCAG, TCCA, TCCC, TCCT, TCCG, TCTA, TCTC,TCTG,TCGT,TTCA,TTCC, TTCG, TTGC,TGAT,TGAG,TGCA, TGCC.
,
-TGGC, TGGT,GAAG, GACT, GACG, GATA,GATC,GATT, GAGT, GCAC.GCCA, GCCc GCCT, GCCG, GCTA,GCTG, GCGT,GCGG,GTAG, GTCT, GTCG, GITC GTGA,GTGG GGAA, GGAT, GGCC, CGCG, GGTA, GGTT, GGTG, AAAAC, AAAAT,MACC,
AAACT, AAATA, AAATT,AAAGA, AACCA, AACTA, AACTC,AATAT AATTA,
~
AATTT, ACTCT, ACTTT ACTTG, ACGCT, ATAAC, ATACT,ATACG,ATCGA,
ATCGC,ATT AA, ATGCT AGAAA, AGAAT ,CACTT, CAT AA,CA T AC,CA TCG,CCCT A
CGCAT, CGCTT, CGTTT TAAAA, TAAAT, TAACC,TAACT, TAATT, TACAA,TACGC TATAC,TATTT,TAGAA.TAGCG, TCTTG, TCGCA, TTACA, TTATA,TTATT TTATG, TTTAC, TTTAT, TTTAG TTTCT, TTTTA, TTTTC,TTTTG, TTGAC,TTGTC, TTGTG TGAAA, TGACA,TGCIT.TGTAA, TGTAT,TGTCA, TGTTA,TGTTG, TGTGT, GAAAA, GAACT, GCAAA,GCATA.GCITT, GCTTG, GTAAA, GTTTA,GTTGT, GTGTA, GGCAT, AAAAAA,ATTTTT, CAAAAA, 111111, TITGTT, GTATAA,ATAATGCGCC.
TATAATGCGC
Trang 22PHI) LVC BS
DONG THOI TRONG CAC TRiNH TTJ E-COLI PROMOTER
NguiJng minsupp=O,3 va mineonC=0,7
{ATA, TTA} =>Promoter+; CF= 0.78; SP= 0,30
{ ATT, TAT} =>Promoter + ; CF = 0,73; SP = 0,30
{TAT, TTA} =>Promoter+; CF= 0,73; SP= 0,31
3 Tren lap Promoter
Trang 24PHT.JLVC B7
? iI:,
TRANG WEB CUA NCBI VE CAC TRINH TTJTu'ONG TV
VOl TRINH TV CO MA UO2740
2: U02872Related Sequences, PubMed, TaxonomyOnchocerca volvulus isolate Guatemala23_tandem repeat sequence
6: UO2856Related Sequences, PubMed, Taxonomy
giI451461IgbIUO2856.110VUO2856[451461]
7: LO4891Related Sequences, PubMed, Taxonomy
giI294025IgbIL04891.110NGTANDRQ(294025]
8: AF281552Related Sequences, PubMed, TaxonomyOnchocerca volvulus isolate S31 0-150 monomer sequence
gill1066758IgbIAF281552.1IAF281552[11066758]
9: U02766RelatedSequences, PubMed, Taxonomy
giI451371IgbIU02766.110VU02766[451371]
Onchocerca volvulus isolate ZaireO5 tandem repeat sequencegiI451418IgbIUO2813.110VUO2813[451418]
Trang 2511: U02873Related Sequences, PubMed, Taxonomy
Onchocerca volvulus isolate Guatemala24 tandem repeat sequen~egiI451478IgbIUO2873.110VU02873[451478]
12: U028S2Related Sequences, PubMed, Taxonomy
giI451457IgbIUO2852.110VU02852[451457]
13: U02734Related Sequences, PubMed, Taxonomy
Onchocerca volvulus isolate Liberia04 tandem repeat sequencegiI451339IgbIU02734.110VU02734[451339]
14: U02812Related Sequences, PubMed, Taxonomy
giI451417IgbIU02812.110VU02812[451417]
15: U02783Related Sequences, Taxonomy
Onchocerca volvulus isolate Mali19 tandem repeat sequencegiI451388IgbIUO2783.110VU02783[451388]
16: J04659Related Sequences, PubMed, Taxonomy
O.volvulus repetitive sequence DNA
giI159883IgbIJO4659.110NGDNARPT[159883]
17: AF2B1545Related Sequences, PubMed, Taxonomy
Onchocerca volvulus isolate 530 0-150 monomer sequence
giI11066751IgbIAF281545.1IAF281545[li066751]
18: AF281531Related Sequences, PubMed, Taxonomy
Onchocerca volvulus isolate 516 0-150 monomer sequence
gilll066737IgbIAF281531.1IAF281531[11066737]
19: AF281549Related Sequences, PubMed, Taxonomy
Onchocerca volvulus isolate S34 0-150 monomer sequence
giI11066755IgbIAF281549.1IAF281549[11066755]
20: U02776Related Sequences, Taxonomy
Onchocerca volvulus isolate Mali12 tandem repeat sequencegiI451381IgbIU02716.110VU02176[451381]
Summary Brief ASN.l FASTA XML GenBank GI list LinkOut
PopSet Links Protein Links PubMed Links Structure Links
Taxonomy Links UniSTS Links
Trang 26'I'TT'I'GG-OVUO:, (j 6 '; : AG'I'TT'I'CMM TTGCC'I' AA- 'I'AACTGATGACCT ATGACCC-T - AA'I'CTCAAAAAACGGGTACATA - CI\T'I'CG/\J\'I"J'GGGTCCTMGMAAATATTCGACCAT
ATTTTGG-(JVUO:' 7 C" : J\G'!"I"I"I'CMAJ\TTGCCTAA-'I'AJ\C'I'GJ\'I'G/\CC'I'J\'I'CACC(;'-'I'-AA'I'C'I'<'III\AIIAII(:(;(;<;'I'/\C/I'I'/,-<:/\'I"I"
'(;I\I\'I"I'(;(;(;'I'(:<:'I'IIAGA/\J\AA'I'/\'j"J'CGACTlITlITTT'!'GG-(IVlln:, H~)'I : lIG'I"I"!"I'ClIAlIATTGCC'!'M-'!'MCT(:/\TGJ\CC'!'ACGAT-CTC-I\lI'I'CTCAIlNIMCGGGTlIC/\'!'A-CJ\'I'T( :,;N\'!"I'(
;GG'!'CC'I'AAGMIIIIJ\TA'!'TCGACCATATTTTGG-(IVI 10:: lJ'I! : lIG'j"J"!"['ClI/\J\A'I"I'GCC'I'M-'!'lIACTClI'I'G/\CC'1'J\'!'l:JIC- J\TJ\TIV\,!,'I"I'c:JI/\J\I\JI/\(:O'"C;'!'AC( ;'1'/1'
AAT-TCAAAAAACGGGTAC-TA-C-TTC-AA-TGGGTCCTAAGAAAAA-ATTCGAC-ATATTTTGG-[ 1 314)
Leaf nodes:
OVUO2841
:MTTTTCAAAATTGCCTAA-TI\ACTGATGACCTATGAC-CCT-MTCTCAAAAAl\CGGGTA~ATA-CATTCGAATTGGGTCCTMGAAA~TATTCGACCATATTTTGG-OVOO2792 OVOO2826 :AATTTTCMMTTGCC'l'AA-TAACTGATGACCTATGAC-CCT-MTCTCAAAAAl\CGGGTACATA-CATTCGMTTGGGTCCTI\AGAAAAATATTCGACCATATTTTGG-
TTTTGG-Ova O:!'7 81 :MTTTTC<~T'rGCCT M -TAACTGATGACCT l\TGAC-CCT -A TTCTCN\AA~CGGGT AC1\TA - CA 'fTCG/V\TTGGGTCCT MGAAAAAT A TTCGACCA TA
1\1"1'1"1'1'1'-C, Area
:AATTTTCAAAATTGCCTAA-TAACTGATGACCTATGAC-CCT-A-TCTCAAAAAACGGGTAC-TA-C-TTC-AA GGGTCCTAAGAAAAATATTCGAC-ATATTTT -[ 1315)
TTTTGG-ovu 0 2 8 'I 5 : AGT'l'TTCl\AMTTGCCT 1\A- '1' AACTGATGACCT A TGAC- CCT -I\ATCTCAAAAAl\CGGGT ACA TA -CATTCGI\A 1'TGGGTCCT'I'AGMMA 1'ATTCGACCA 'I' A
TTTTGG-nVI)O:: « 2 \ :AGT'I'T'I'CMAA TTGCCT l\A-TI\ACTGATGACCT A TGAC-CCT -1'.1\ TC'I'CI\AMAACGGGTAC1\T 1\ - CATTCG1'.1\'l'TGGG'rCCTT AG1\1'.A.AA 1'ATTCGACCA l' A
TTTTGG-UVU 0 2 8 4 7 : AGTT1'TCMM TTGCCT M- '!'I\ACTGATGACCT ATGAC-CCT -MTCTCAAAM/\CGGGT ACATA-CATTCGI\A TTGGGTCC'l' I\AGAMMT ATTCGACCATA
TTTTTG-tJVU02859
:AGT'I'1'1'CMMT'I'GCC'I'AA-'!'MC'!'GATGACC'!'ATGAC-CCT-AA'!'CTCAAAAAl\CGGG1'AC1\1'A-CA'!"J'CGAAT1'GGGTCCT1'AG~1'ATTCGACCATA'!'TT1'GG-OVU02870
IAG'!'T'!'TCAAAATTGCTTI\A-'!'I\AC'J'GATGACCTATGA-CCC1'-I\ATC'!'CAAAAAl\CGGGTACATA-CA1'1'CGAA1'1'GGGTCCTAAGAAAAATATTCGACCA1'ATTTTGG-I JIAG'!'T'!'TCAAAATTGCTTI\A-'!'I\AC'J'GATGACCTATGA-CCC1'-I\ATC'!'CAAAAAl\CGGGTACATA-CA1'1'CGAA1'1'GGGTCCTAAGAAAAATATTCGACCA1'ATTTTGG-I.GTTT'!'CN\AIAG'!'T'!'TCAAAATTGCTTI\A-'!'I\AC'J'GATGACCTATGA-CCC1'-I\ATC'!'CAAAAAl\CGGGTACATA-CA1'1'CGAA1'1'GGGTCCTAAGAAAAATATTCGACCA1'ATTTTGG-I\ TTGCCTf\.1\ - '; [";'.CT ':X!'GTCCT A TGTC-CCT -.".f',':":T" :',"'",ol\.',hCGGGT I\C.', 'I'l\ - Cr,T"""~,\,:',',':' }::;GT«:'1'.";\G1';'.p.1']\ l' A 1'TCG/\CCAT 1,
1'T1'TGG-')\11)0 ::: '!68 : AGTTTTCAAMTTGCCTI\A-T1\1\CTGA- - -CCTATGI\C-CCT-I\ATCTCi'J\1\lI.AACGGGTACAT
A-<::!'.TTCr;!\I\TTGGGTCCT1'AGN',AAA1'ATTCGI\CCA1'I\TTTTGG-C- Area
:AGTTTTCAAMTTGC-TAA-TAACTGA -C-TATG -CCT-AATCTCAAAAAACGGGTACATA-CATTCGAATTGGGTCCT-AGAAAAATATTCGACCATATTTT-G-[ 1 3 16)
OVUO2863
:AGTT1'TCMMTTGCCTAA-TAATTGATGACCTATGAC-CC-TI\A1'C1'CAAAAAl\CGGG1'ACATA-C/WTCGAAT'J'GGGTCCTMGAAAAATATTCGACCAT1\T1'TTGG-OVlJ02793
:AGTT1'TCAAAA1'TGCC1'I\A-TI\A1'1'GATGACCTATGAC-CC-1'I\A1'~CAAMMCGGGTACATA-CATTCGM1'1'GGGTCC1'I\AG~1'ATTCGACCA1'A1'TTTGG-nv! [C' "7~1 : AGTTTTCAAAA TTGCCT M -1' p.}\TTGATGACCT ATGI-\C-CC-TN'" T"'!'CiV'JlI\AACGGGT ACI, T A-CATTCGAi',T'l'GGA TCCT Al\G1.J\/\l\A 'I'1'.TTCG!'.CXAT
ATTTTG(~ ' :NJT'1"l"l'Ci0,AA')"i'(;C'~:Ti.",-'i.""" ,l':.v~'.;:':d'Ui.:':-":C',/'",,, "'",,vc",;,GGGT,;;;;',,!,',- '.',:: -" _;,;;n""j',~, ;.,.,~',i",T.:,:"li.::"':\C'J:,.":l::
,;vue " 6 'OJ : r,GTT1'TCAAAATTGCCT.~-Ti'J\CTGATGACCTATG/-\C- -CCTlV,TC1'Cfv' AJ\A1\CGGGTACAT 1,-C,"/l';TGi\l\TTGGGTCCTI-'J'.GAAp GA TATTCGACCATI,T'I"j"I'CC"
\4!.>
115 66 96 118 55 103
136 119 95 121 133 144 49 42
137 67 68
.'j 't'13
56 113
Trang 27POD LUC B9
NGUON GOC CAC GEN KHUAN ONCHOCERCA
(Ngu6n WebSite NCBI: htt{J:/Iwww.ncbi.nlm.nil.~ov/)
OVUO2591:0nchocerca volvulus tandem repeat sequence 2
OVUO2593:0nchocerca volvulus tandem repeat sequence 4
OVUO2734:volvulus isolate LiberiaO4 tandem repeat sequence
OVUO2735: Onchocerca volvulus isolate LiberiaO5 tandem repeat sequence
OVUO2738:0nchocerca volvulus isolate LiberiaO8 tandem repeat sequence
OVUO2740:0nchocerca volvulus isolate Liberia10 tandem repeat sequence.OVUO2741:0nchocerca volvulus isolate Liberia11 tandem repeat sequence.OVUO2742:0nchocerca volvulus isolate Liberia12 tanaem repeat sequence.OVUO2743:0nchocerca volvulus isolate Liberia13 tandem repeat sequence.OVUO2744:0nchocerca volvulus isolate Liberia14 tandem repeat sequence.OVUO2745:0nchocerca volvulus isolate Liberia15 tandem repeat sequence.OVUO2746:0nchocerca volvulus isolate Liberia16 tandem repeat sequence.OVUO2747:0nchocerca volvulus isolate Liberia17 tandem repeat sequence.OVUO2748:0nchocerca volvulus isolate Liberia18 tandem repeat sequence.OVUO2749:0nchocerca volvulus isolate Liberia19 tandem repeat sequence.OVUO2750:0nchocerca volvulus isolate Liberia20 tand~m repeat sequence.OVUO2751:0nchocerca volvulus isolate Liberia21 tandem repeat sequence.OVUO2752:0nchocerca volvulus isolate Liberia22 tandem repeat sequence.OVUO2753:0nchocerca volvulus isolate Liberia23 tandem repeat sequence.OVUO27S4:0nchocerca volvulus isolate Liberia24 tandem repeat sequence.OVUO27S5:0nchocerca volvulus isolate Liberia25 tandem repeat sequence.OVUO2756:0nchocerca volvulus isolate Liberia26 tandem repeat sequence.OVUO2757:0nchocerca volvulus isolate Liberia27 tandem repeat sequence.OVUO27S8:0nchocerca volvulus isolate Liberia28 tandem repeat sequence.OVUO2759:0nchocerca volvulus isolate Liberia29 tandem repeat sequence.OVUO2760:0nchocerca volvulus isolate Liberia30 tandem repeat sequence.OVUO2761:0nchocerca volvulus isolate Liberia31 tandem repeat sequence.OVUO2762:0nchocerca volvulus isolate Liberia32 tandem repeat sequence.OVUO2763:0nchocerca volvulus isolate Liberia33 tandem repeat sequence.OVUO2764:0nchocerca volvulus isolate Liberia34 tandem repeat sequence.OVUO2765:0nchocerca volvulus isolate MaliO1 tandem repeat sequence.OVUO2766:0nchocerca volvulus isolate MaliO2 tandem repeat sequence.OVUO2767:Onchocerca volvulus isolate MaliO3 tandem repeat sequence.OVUO2768:0nchocerca volvulus isolate MaliO4 tandem repeat sequence.OVUO2769:0nchocerca volvulus isolate MaliOS tandem repeat sequence.OVUO2770:0nchocerca volvulus isolate MaliO6 tandem repeat sequence.OVUO2771:Onchocerca volvulus isolate MaliO7 tandem repeat sequence.OVUO2772:0nchocerca volvulus isolate MaliO8 tandem repeat sequence.OVUO2773:0nchocerca volvulus isolate MaliO9 tandem repeat sequence.OVUO2774:0nchocerca volvulus isolate Mali10 tandem repeat sequence.OVUO277S:0nchocerca volvulus isolate Mali11 tandem repeat sequence.OVUO2776:0nchocerca volvulus isolate Mali12 tandem repeat sequence
sequence.sequence.sequence
Trang 28PLB9-3
BrazilO8 tandem repeat sequence
BrazillO tandem repeat sequence.Brazilll tandem repeat sequence
Brazill3 tandem repeat sequence.Brazill4 tandem repeat sequence.Brazill5 tandem repeat sequence
Brazill7 tandem repeat sequence.Brazill8 tandem repeat sequence.Brazill9 tandem repeat sequence.Brazil20 tandem repeat sequence.GuatemalaOl tandem repeat sequence.GuatemalaO2 tandem repeat sequence.GuatemalaO3 tandem repeat sequence.GuatemalaO4 tandem repeat sequence.GuatemalaO5 tandem repeat sequence.GuatemalaO6 tandem repeat sequence.GuatemalaO7 tandem repeat sequence.GuatemalaO8 tandem repeat sequence.GuatemalaO9 tandem repeat sequence.GuatemalalO tandem repeat sequence.Guatemalall tandem repeat sequence.Guatemalal2 tandem repeat sequence.Guatemalal3 tandem repeat sequence.Guatemalal4 tandem repeat sequence.Guatemalal5 tandem repeat sequence.Guatemalal6 tandem repeat sequence.Guatemalal7 tandem repeat sequence.GuatemalalB tandem repeat sequence.Guatemalal9 tandem repeat sequence.Guatemala20 tandem repeat sequence.Guatemala21 tandem repeat sequence.Guatemala22 tandem repeat sequence.Guatemala23 tandem repeat sequence
Gua temala2 4 tandem repea t sequence
Guatemala25 tandem repeat sequence.Guatemala26 tandem repeat sequence
Trang 29[1 2] #Entries: 9, Level 1 (Internal), Sibling: 0, Size: 32886/53248
[1 2 4] #Entries: 11, Level O(Leaf), Sibling: 0, Size: 40190/53248
[1 2 5] #Entries: 14, Level O(Leaf), Sibling: 0, Size: 51146/53248
Trang 30O Volvunus isolate Guatemala12 DNA sequence.
#Entries: 10, Level O(Leaf), Sibling: 0, Size: 36538/53248
O Volvunus isolate Zaire17 DNA sequence
O Volvunus isolate Zaire20 DNA sequence
O Volvunus isolate Brazil06 DNA sequence
O Volvunus isolate Brazil11 DNA sequence
O Volvunus isolate Brazil04 DNA sequence
O Volvunus isolate Liberia22 DNA sequence
O Volvunus isolate Mali08 DNA sequence
O Volvunus isolate Brazi120 DNA sequence
O Volvunus DNA sequence 5
O Vo1vunus isolate Liberia32 DNA sequence
#Entries: 6, Level O(Leaf), Sibling: 0, Size: 21930/53248
O Volvunus isolate Guatemala25 DNA sequence
O Volvunus isolate Liberia47 DNA sequence
O Volvunus isolate Brazil01 DNA sequence
O Volvunus DNA sequence 1
O Volvunus isolate Mali03 DNA sequence
O Volvunus isolate Mali06 DNA sequence
#Entries: 9, Level O(Leaf), Sibling: 0, Size: 32886/53248
O Volvunus isolate Mali23 DNA sequence
O Volvunus isolate Liberia23 DNA'sequence
O Volvunus isolate Zaire02 DNA sequence
O Volvunus isolate Mali01 DNA sequence
O Volvunus isolate Liberia36 DNA sequence
O Volvunus isolate Guatemala02 DNA sequence
O Volvunus isolate Liberia38 DNA sequence
O Volvunus isolate Zaire01 DNA sequence
O Volvunus isolate Brazil08 DNA sequence
#Entries: 6, Level O(Leaf), SibliJg: 0, Size: 21930/53248
O Volvunus isolate Liberia02 DNA sequence
O Volvunus isolate Liberia03 DNA sequence
O Volvunus isolate Liberia52 DNA sequence
O Volvunus isolate Liberia42 DNA sequence
#Entries: 11, Level O(Leaf), Sibling: 0, Size: 40190/53248
O Volvunus isolate Liberia33 DNA sequence
O Volvunus DNA sequence 3
O Volvunus isolate Liberia15 DNA sequence
O Volvunus isolate Liberia24 DNA sequence
O Volvunus isolate Liberia30 DNA sequence
O Volvunus isolate Liberia25 DNA sequence
O Volvunus isolate Liberia26 DNA sequence
O Volvunus isolate LiberiaO7 DNA sequence
O Volvunus isolate Liberia16 DNA sequence
O Volvunus isolate Liberia28 DNA sequence
O Volvunus DNA sequence 2
#Entries: 8, Level O(Leaf), Sibling: 0, Size: 29234/53248
O Volvunus isolate Liberia21 DNA sequence
O Volvunus isolate LiberiaO9 DNA sequence
O Vo1vunus isolate LiberiaO5 DNA sequence
O Volvunus isolate Liberia08 DNA sequence
O Volvunus isolate Liberia34 DNA sequence
O Volvunus isolate GuatemalaO8 DNA sequence
O Volvunus isolate Liberia17 DNA sequence
Trang 31B 10-3
[1 3] #Entries: 8, Level 1(Internal), Sibling: 0, Size:
[1 3 13] #Entries: 8, Level O(Leaf), Sibling: 0, Size:
[1 3 14] #Entries: 6, Level O(Leaf), Sibling: 0, Size:
[1 3 15] #Entries: 8, Level O(Leaf), Sibling: 0, Size:
[1 3 16] #Entries: 7, Level O(Leaf), Sibling: 0, Size:
[1 3 17] #Entries: 7, Level O(Leaf), Sibling: 0, Size:
[1 3 18] #Entries: 9, Level O(Leaf), Sibling: 0, Size:
Trang 32O Volvunus isolate Guatemala15 DNA sequence.
o Volvunus isolate Liberia49 DNA sequence
#Entries: 12, Level Q(Leaf), Sibling: 0, Size:
O Volvunus isolate L.iberia19DNA sequence
O Volvunus isolate Liberia13 DNA sequence
O Volvunus isolate Liberia18 DNA sequence
O Volvunus isolate Liberia14 DNA sequence
O Volvunus isolate Liberia50 DNA sequence
O Volvunus isolate L.iberia21 DNA sequence
O Volvunus isolate Liberia48 DNA sequence
O Volvunus isolate Zaire16 DNA sequence
O Volvunus isolate Zaire08 DNA sequence
o Volvunus isolate Zaire06 DNA sequence
O Volvunus isolate Liberia12 DNA sequence
O Volvunus isolate Zaire07 DNA sequence
#Entries: 1, Level O(Leaf), Sibling: 0, Size:
O Volvunus isolate Liberia45 DNA sequence
O Volvunus isolate Guatemala11 DNA sequence
O Volvunus isolate Liberia55 DNA sequence
O Volvunus isolate LiberiaO6 DNA sequence
O Volvunus isolate Brazil11 DNA sequence
O Volvunus isolate Guatemala18 DNA sequence
O Volvunus isolate Liberia11 DNA sequence
43842/53248
25582/53248
Trang 33PHV LVC Cl
CAC DAY TU PHO BIEN TRONG TRUY~N NGAN
NG!M Cu'OI CUA NHA VAN NGUYEN CONG HOAN
Ngu6n: Ti~u thuye't thu bay 86188; 1938.
so' call 107
*** Chen cae call cua truy~n ngiin vito cay Mu t6md r{)ng *******
sl:1fmg toi bay giOsa dI dU'<;fc yen 6n, Ia nha long can dam, nghTahi~p cua anh cu ban, da: li~o minh kham pha ra cai t6 trQmcU'dp a dnh rltng thong.
s2:sao thang v~ truoe, loon mQtd~o, nhii'ng Ilk dem khuya, tTnhmieh, khong c6 trang,
it nguai dam dua milt ra ngofli san to'i mil
s3:nghe ngQn gi6 fit qua khe lie'p cling du tr<;fn!h~ c6 tie'ng ch6 r6 leu sua khan a xom
ba song, la ngay tit dua be leu hai cling bie't gi~t rnlnh.
s4:n6 kh6c thet len, am ehitm la'y m~.
s5:.
s6:.
s7:m~ n6 YO,xoa, ru khe khe de lang tal nghe.
s8:r6i ne'o mQt h6i tu va d~y len, thi ong gia v~n to ng<.>n den boa ky, ng6i nh6m d~y, hung ha:ng ho, ho~c hUtthuo'clao, cho da ve I~ngIe.
s9:nhung b6ng viing nghe a dau keu eudp, r6i tr6ng daub lien thanh, tie'ng kh6e nhtr n,
tu va rUc, ch6 sua l~c tie'ng,li~n 1i~nnhau tit lang nay de'n lang khac, dai hang ma'y cay so', thi ngU'aieung b6ng via de'n dau ding
slO:mU'aito'ithi de'nbo'nDam to'ikinh khung nhurne'.
s II :ma bQn cuop nit tai, ban ngay chUngkheo lifnhIt trong dnh drng thOng.
sl2:eae nM chuyen tnich ma'y lfin cho Hnh vao s1,1c ding khong bilt du<;fc.
s13:++ +hlc a'y, vao khoang bo'n giOchi~o.
sI4:eh! cu ban dudng ng6i nh~t ran trong be'p, thi ch6ng v~.
sl5:net m~t ham hd, anh noi:- nay 0 no, quaD da:dt toj r6i.
sI6:ch! ngd ngac:- dt gi?- dt di ba:tt6 cU'dprung thong?xam ngiit m~t, chi gilt:- quail bilt thfty no vao ch6 che't ma cling nghe a?anh eu venh rn~t, kieu eang, dap:- chi n6i d~i! vi~c gi ma che't.
sl7:ehinh toi tinh nguy~n vdi quail d~ xin di!chi en oa leu kh6c:- thfiy no na bo m~ wn toi che't d6i hay saD?kh6 qua! toi bie't trong c~y V3.0ai dU'Qc?thftyno dung di!ba d(ra
be, ngd ngae nhin cha m~, cling 03.ten kh
s 18:anh co earn dQng,an ui v<;f: - u no cU'yen long.
Trang 34sl9:the nao sang mai toi cling v~.
s20:neu toi khong ra tay, r6i qUaDettdp cu nhung nhi~u mai, vung nay con ai lam an gi du<;1c!- danh v~y, nhttng 16 fa.
s21:.
s22:.
s23:- thi cling danh ch1i'saD? toi tam vic$cich cho mQi nguoi ma u n6 ding cu ngan can s24:- lam ich cho nha giau, chu nhii'ngh~ng nhum1nh thllo gl bi cudp? toi chi scJ16 ca thl mQt nach ba con mQn,toi biet lam the nao?- u may dung da hdi! vic$cgl ma 10xa nhuthe? toi se dtt<;1c thuang.
s25:quan hua r6i.
s26:neu thanh eong, ta khong phai vit va nhu'the nay mla.
s27:- thai, toi van th~y n6 dung d~i dQt.
s28:toi khong M eho th~y n6 di dati.
s29:anh eu quAemAt,n6i:- vic$equaDdo phai vic$etft~can! u n6 khong dU<;1c n6i the s30:chi eu l~i oa leDkh6c, turn ehiJ.tliy ao eh6ng.
s31 :anh eu gi~ng fa, mhg:- u no khong dU<;1e gill'
-s32:quan va Hnheho toi ngoai dlnh kia.
s33:M toi di, keDeh~m.
s34:- khong! khong di! th.1y n6 hay an edm da, vQigl.
s35:- khong do.
s36:da c6 edm eua quaD.
s37:toi phai di ngay bay gio moilqp. ~
s38:n6i do~n anh cu nhit dinh dt1'tao ra di.
s39:anh om ba con vao long, xoa d.1u,diJ.ndo rnly call, r6i ra e6ng.
s40:chi eu be con, kh6c 16etheo ch6ng.
s41 :nhttng vh than nhien, anh cu eoi nh~ ngrua vCJeh6ng, tlnh cha con.
s42:den d.1ulang, anh ri tai n6i vdi khan tM keDchi eu tra l~i.
s43:++ +s11thanh cong cua anh cu ban dii lam cho vCJanh goa eh6ng! dem hOrnd6 nhiJ anh can dam, qUaDeu'dpIii lu<;1t bi giai len huy~n.
Trang 35s53:hQ xui chi eu ban be' d ba dti'acon leD ken quaDph1,1 mh thudng de'n tlnh dnh nheo nhoc cua c~ ma cho mQt men ti€n b6i thuong.
s54:quan huy~n nit Ul'te'.
s55:ngai noi:- nba ell! khong phai ken, b6n ph~n ta Ia phai b£m Ien quail tren xet dtn nguoi co congo
s56:cti'v€ ma cho d<Jiit Ian.
s57:r6i chi se khong phai phan Danv€ slf an thudng dich dang cua ch6ng chi.
s5S:++ +om t!m mong moi, chi eu ban vui vi: v€ nha, k€ ehuy~n cho mQi nguoi nghe s59:ai cling co bl:mgmling thay cho chi.
s60:thuong khi lam an va't va, du<JCbua nay, 10bua mai, ch! lC;linha thudng ch6ng s61 :nhung ch! I!y ngay eai hy vQngfa d€ tlf an Iii.
s62:ne'u du<Jcchuang,ch! dung man ti€n d€ sinh l<ji,thl ch5c du<jcau an su6t doi s63 :nam horn, muoi horn.
s64:cai tro mong vin hay tha'y Iau.
s65:chu ch! bie't dau la ddn cua cll! con phai qua loa nay sa nQ, co khi no di cMm va hay nghi nhu ong CQgia.
s66:r6i ml'a chang, IC;li mQtchang.
s67:cll! cu ban ding ngay Gangquiin bach.
s6S:cdm chhg du nuoi con.
s69:nha dQt, khong ai giQihQ.
s70:san reo, co mQc.chi chhg co hie n~lOsth sang.
s71:ma'y Qua be beure'ch.
s72:nhung bie't lam the' nao? ne'u ell! d nM trong nom chang, thl ai ai lam h,lllgkie'm mie'ng cho ma an? gia chUnglon, dQleD bay len tam d, thi cll! dii cho mQtalia di d dE
do phai nodi.
s73 :kh6n nhung thhg Ion moi len Dam tu6i.
s74:r6i nua, mQtthang, hai chang.
s75:nguoi ta th!y ell!eu ban rach moi.
s76:khong ai khong pban nail cho cll!.
s77:mc:j.tmlii c~ h6e hac, den Qui,xa'u xa.
s7S:nguoi ta hoi tham, ell! d€u treiloi:- nay mai, toi se co man ti€n chuang.
s79:thudng.
sSO:cai do khong the khong co.
sSI :cha:c Ia:mr6i.
sS2:quan dil hua the'.
sS3:nhU'nghorn nay cll! chua co gl ca.
sS4:cll! Dong ruQt.
sS5:kh6.
sS6:nhung, nh!t d!nhcll! cho cai tltdng lai.
s87:<1ngoai, hQd6n chao len da'y.
s88:co nguoi mong chi du<jcchuang mQt nghln bC;lC.
Trang 36PIDJ LVC Al KHAITHACLUATKETHOP