Dermatology therapy essentials - part 1 doc

A Abrikossof’s tumor ᭤ Granular cell tumor Abscess Definition Accumulation of pus in tissue, usually caused by a bacterial infection ᭤ Furuncle References Lowy, FD (1998) Staphylococcus aureus infections. New England Journal of Medicine 339:520–532 Academy rash ᭤ Erythema infectiosum Acanthamebiasis Synonym(s) None Definition Cutaneous and/or systemic infection caused by one of several species of acanthamoeba Pathogenesis Opportunistic infection, most often in an immunocompromised host, particularly with HIV disease Clinical manifestation Multiple pustules; infiltrated papules and plaques; subcutaneous nodules; non-heal- ing cutaneous ulcers; distribution mainly on the extremities Differential diagnosis Furunculosis; disseminated varicella/zoster infection; deep fungal infection; bacillary angiomatosis; myctobacterial infection; pyoderma gangrenosum Therapy Multidrug regimen for systemic disease: pentamidine; flucytosine; fluconazole; sul- fadiazine References Murakawa GJ, McCalmont T, Altman J, Telang GH, Hoffman MD, Kantor GR, Berger TG (1995) Disseminated acanthamebiasis in patients with AIDS. A report of five cases and a review of the literature. Archives of Dermatology 131(11):1291–1296 PART1.MIF Page 1 Wednesday, October 29, 2003 4:13 PM 2 Acanthoma fissuratum Acanthoma fissuratum Synonym(s) Granuloma fissuratum ; spectacle frame granuloma ; acanthoma fissuratum cutis Definition Keratotic papule or nodule which develops at the site of chronic irritation, such as under eye glasses or in the oral cavity Pathogenesis Chronic contact irritation; includes other factors such as local anatomic changes, seborrheic dermatitis, and hyperhidrosis Clinical manifestation Oral cavity: solitary smooth-surfaced papule at the juncture of the lip and gum Face or post-auricular fold: pink papule with a longitudinal central fissure Differential diagnosis Oral cavity: squamous cell carcinoma. Skin: basal cell carcinoma; foreign body granuloma; chondrodermatitis nodularis helicis Therapy Removal of stimulus by changing eye glasses, dentures, etc.; surgical excision in recalcitrant cases References Frey T, Bartak P (1992) Acanthoma supratro- chantericum. Cutis 49(6):412–416 Acanthoma fissuratum cutis ᭤ Acanthoma fissuratum Acanthome à cellules claires ᭤ Clear cell acanthoma Acanthosis nigricans Synonym(s) None Definition Hyperpigmented, velvety thickening of the skin; most commonly on the neck, in the axillae, and in the groin Pathogenesis Caused by factors that stimulate epidermal keratinocyte and dermal fibroblast prolifer- ation, such as insulin or an insulin-like growth factor Clinical manifestation Symmetrical, hyperpigmented, velvety plaques, which most commonly appear in the intertriginous areas; skin tags in the vicinity of the plaques Differential diagnosis Becker nevus; confluent and reticulated papillomatosis of Gougerot and Carteaud; Dowling-Degos disease; seborrheic kerato- sis; ichthyosis hystrix; linear epidermal nevus; parapsoriasis en plaque; pemphigus vegetans; hemochromatosis; Addison’s disease; pellagra Therapy Correction of underlying disease process; weight reduction in obese patients; tretinoin 0.025% cream; adapalene 0.1% gel; cal- cipotriene; dietary fish oils; dermabrasion References Hud JA Jr, Cohen JB, Wagner JM, Cruz PD Jr (1992) Prevalence and significance of acanthosis nigricans in an adult obese population. Arch Dermatol 128: 941–944 Accessory nipples ᭤ Supernumerary nipple PART1.MIF Page 2 Wednesday, October 29, 2003 4:13 PM Acinetobacter infection 3 A Accessory tragus Synonym(s) Supernumerary ear ; supernumerary auricle ; accessory external ear ; rudimentary auricle ; accessory auricle ; auricular appendage ; cervical auricle ; preauricular appendage ; cutaneous cervical tag ; preauricular appendage ; wattle Definition Congenital anomaly of branchial arch development, producing a preauricular papule Pathogenesis Abnormal development of portions of one of the branchial arches Clinical manifestation Asymptomatic, solitary, flesh-colored papule, usually in the preauricular area; vel- lus hairs arise from the papule Differential diagnosis Preauricular cyst or sinus; thyroglossal duct cyst; branchial cyst or sinus; bronchogenic cyst; acrochordon; melanocytic nevus; epidermoid cyst; neurofibroma Therapy Surgical excision References Jansen T; Romiti R; Altmeyer P (2000) Accessory tragus: report of two cases and review of the literature. Pediatric Dermatology 17:391–394 Accutane ᭤ Isotretinoin Acetowhite test Synonym(s) None Definition Application of 3% acetic acid to lesions sus- picious for human papillomavirus infection; positive test indicated by lesion turn- ing white References Kitchener HC, Symonds P (1999) Detection of cervical intraepithelial neoplasia in developing countries. Lancet 353:869–873 Achromic nevus ᭤ Nevus depigmentosus Acinetobacter infection Synonym(s) None Definition Infection caused by Acinetobacter, a gram negative organism Accessory tragus. Solitary preauricular flesh- colored papule PART1.MIF Page 3 Wednesday, October 29, 2003 4:13 PM 4 Acitretin Pathogenesis Opportunistic infection from an organism which is often a part of the normal flora in the axilla and groin; increased sweating resulting in higher carriage levels; skin involvement usually colonization rather than infection Clinical manifestation No physical findings in colonized patients; skin pustules, cellulitis with clinical infection Differential diagnosis Other gram negative infections; ecthyma; staphyloccal cellulitis Therapy No therapy for colonization; treatment of active infection dependent on sensitivities of the organism in the individual patient References Cunha BA, Klein NC (1995) Pseudoinfections: a review. Infectious Disease Clinical Practice 4:95–103 Acitretin Trade name(s) Soriatane Generic available No Drug class Retinoid Mechanism of action Induction of cellular differentiation; anti- inflammatory; anti-proliferative Dosage form 10 mg, 25 mg capsule Dermatologic indications and dosage See table Common side effects Cutaneous: cheilitis, sticky skin, alopecia, dry skin, pruritus, paronychia, desquama- tion of hands and feet Laboratory: hyperlipidemia Musculoskeletal: myalgias; arthralgias Ocular: dry eyes Serious side effects Gastrointestinal: pancreatitis, hepatotoxic- ity Miscellaneous: major birth defects Musculoskeletal: spinal hyperostosis Neurologic: pseudotumor cerebri Drug interactions Norethindrone; methotrexate Other interactions Alcohol Contraindications/precautions Hypersensitivity to drug class or component; pregnancy; renal or hepatic dysfunc- tion; children may be more sensitive to the drug’s effect on bones, which may prevent normal bone growth during puberty References Katz HI, Waalen J, Leach EE (1999) Acitretin in psoriasis: an overview of adverse effects. Jour- nal of the American Academy of Dermatology 41(3 Pt 2):S7–S12 Ackerman tumor ᭤ Ve rr uc o us carcinoma Ackerman’s tumor ᭤ Ve rr uc o us carcinoma PART1.MIF Page 4 Wednesday, October 29, 2003 4:13 PM Ackerman’s tumor 5 A Acitretin. Dermatologic indications and dosage Disease Adult dosage Child dosage Balanitis xerotica obliterans 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Berardinelli-Seip syndrome 75 mg PO daily 10–25 mg PO daily Darier disease 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Epidermolytic hyperkeratosis 0.5–1 mg per kg PO daily indefinitely 0.5 mg per kg PO daily indefinitely Erythrokeratodermia variabilis 25–50 mg PO daily indefinitely 10–25 mg PO daily Graft-versus-host disease 1 mg per kg PO daily 10–25 mg PO daily Hairy tongue 25–50 mg daily for up to 5 months 10–25 mg PO daily Harlequin ichthyosis 1 mg per kg PO daily 1 mg per kg PO daily indefinitely Hidradenitis suppurativa 1 mg per kg PO daily for 4–8 months 10–25 mg PO daily Hyperkeratosis lenticularis perstans 25–50 mg PO daily indefinitely 10–25 mg PO daily Kyrle’s disease 1 mg per kg PO daily for 4–8 months 10–25 mg PO daily Lamellar ichthyosis 1 mg per kg PO daily 10–25 mg PO daily Lichen planus 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Lichen sclerosus 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Lipoid proteinosis 25–50 mg daily for up to 5 months 10–25 mg PO daily Lupus erythematosus 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Mal de Meleda 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Nevus verrucosus 25–50 mg daily for up to 5 months 10–25 mg PO daily Olmsted syndrome 1 mg per kg PO daily 10–25 mg PO daily Pachonychia congenita 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Palmoplantar keratoderma 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Papillon-Lefévre syndrome 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Papular mucinosis 1 mg per kg PO daily 10–25 mg PO daily Pityriasis rubra pilaris 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Progressive symmetric erythrokeratodermia 25–50 mg PO daily indefinitely 10–25 mg PO daily PART1.MIF Page 5 Wednesday, October 29, 2003 4:13 PM 6 Acne aestivalis Acne aestivalis Synonym(s) Mallorca acne Definition Monomorphous follicular papular eruption which occurs after sun exposure Pathogenesis Sun exposure appears to produce the lesions; may be a variant of polymorphous light eruption; hypersensitivity reaction to sunscreens or cosmetics possible contributing factor Clinical manifestation Monomorphous follicular papules over the shoulders, arms, chest, and neck; no comedones present Differential diagnosis Folliculitis; acne vulgaris; steroid acne; insect bite reaction; polymorphous light eruption Therapy Tretinoin 0.025% cream; benzoyl peroxide 5% gel; prophylaxis by increasing expo- sures to artificial ultraviolet radiation to “harden” the skin to the effects of sunlight References Plewig G, Jansen T (1998) Acneiform dermatoses. Dermatology 196:102–107 Acne atrophica ᭤ Acne necrotica Acne comedonica Synonym(s) Comedonal acne; blackheads; whiteheads Definition Open and closed comedones on the face, chest, and back Pathogenesis Accumulation of corneocytes in the follicular infundibulum, producing a spherical dermal papule (see acne vulgaris); cause unknown but may involve stimulation of the follicular lining and sebaceous duct by exogenous compounds, an endogenous hormonal stimulus, or a neurologic stimulus Psoriasis 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Reiter syndrome 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Striate keratoderma 0.5–1 mg per kg daily indefinitely 10–25 mg PO daily Subcorneal pustular dermatosis 1 mg per kg PO daily 10–25 mg PO daily Tyrosinemia II 0.5–1 mg per kg daily indefinitely 10–25 mg PO daily Vohwinkel’s syndrome 25–50 mg PO daily as a single dose; after four weeks, 25–75 mg PO daily 10–25 mg PO daily Acitretin. Dermatologic indications and dosage (Continued) Disease Adult dosage Child dosage PART1.MIF Page 6 Wednesday, October 29, 2003 4:13 PM Acne excoriée 7 A Clinical manifestation Open comedone: skin-colored or white, slightly elevated papule with a punctate central opening Closed comedone: slightly raised papule with a central black keratotic plug Differential diagnosis Milium; epidermoid cyst; giant pore of Winer; nevus comedonicus; Favre-Racou- chot disease; radiation acne; acne cosmet- ica; chloracne; trichostasis spinulosa; flat warts; appendageal tumors (syringoma, etc.); sebaceous gland hyperplasia Therapy Tretinoin cream 0.025% ଙ ; tazarotene 0.1%; adapalene 0.1% gel ଙ ; benzoyl peroxide 5% gel; azelaic acid 20% cream; salicylic acid 1– 2% cream or gel; alpha hydroxy acid preparation; trichloroacetic acid 10–20% peel References We bster, GF (1999) Acne vulgaris. Archives of Dermatology 135:1101–1102 Acne conglobata Synonym(s) Conglobate acne Definition Inflammatory disease characterized by cysts, double-headed comedones, abscesses, sinus tracts, and severe scarring; occurs almost exclusively in adult men Pathogenesis Unknown Clinical manifestation Numerous large comedones with multiple openings; multiple inflammatory papules, pustules, nodules, and cysts; distribution of lesions over back, chest, buttocks, arms, abdomen, and thighs; heals with deep pit- ted scars and hypertrophic scars Differential diagnosis Acne inversa; acne fulminans; chloracne; tropical acne Therapy Isotretinoin ଙ ; prednisone for extreme acute flares; dapsone; incision and drainage of suppurative cysts and nodules; triamcinolone 3–5 mg per ml intralesional to inflamed cysts; liquid nitrogen cryotherapy for hemorrhagic nodules; surgical excision and skin grafting of chronically involved sites References Chicarilli ZN (1987) Follicular occlusion triad: hidradenitis suppurativa, acne conglobata, and dissecting cellulitis of the scalp. Annals of Plas- tic Surgery 18:230–237 Acne decalvans ᭤ Folliculitis decalvans Acne excoriée Synonym(s) Picker’s acne; excoriated acne Definition Acne lesions which are excoriated Pathogenesis Self-induced lesions, often in patients whose acne becomes a source of extreme mental distress Clinical manifestation Irregular crusts at sites of acne which have been excoriated Differential diagnosis Atopic neurodermatitis; depression with self-mutilation; ecthyma; herpes simplex virus infection PART1.MIF Page 7 Wednesday, October 29, 2003 4:13 PM 8 Acne frontalis Therapy Treatment of underlying acne (see acne vulgaris); discussion of the cause of the excori- ations; psychotherapy in selected patients References Arnold LM, Auchenbach MB, McElroy SL (2001) Psychogenic excoriation. Clinical features, pro- posed diagnostic criteria, epidemiology and approaches to treatment. CNS Drugs 15:351–359 Acne frontalis ᭤ Acne necrotica Acne inversa ᭤ Hidradenitis suppurativa Acne keloid ᭤ Acne keloidalis Acne keloidalis Synonym(s) Acne keloidalis nuchae; folliculitis keloidalis; folliculitis keloidalis nuchae; acne keloid Definition Chronic inflammatory process of the hair follicles leading to keloidal papules and plaques on the occipital scalp and posterior neck Pathogenesis Theories: injury produced by short hair- cuts; irritation from shirt collars; chronic low-grade bacterial infections; autoim- mune process; primary scarring alopecia; weakened follicular wall with subsequent rupture and foreign body reaction Clinical manifestation Firm, dome-shaped, follicular papules, which develop on the nape of the neck and/ or on the occipital scalp; papules coalesce into plaques; scarring alopecia and subcutaneous abscesses with draining sinuses occur later in the course Differential diagnosis Folliculitis; acne vulgaris; perifolliculitis capitis abscedens et suffodiens; nevus sebaceous of Jadassohn; keloid; pediculosis capitis; hidradenitis suppurativa; seborrheic dermatitis; squamous cell carcinoma; basal cell carcinoma Therapy Avoidance of trauma to the neck and posterior scalp area; triamcinolone (5–10 mg per ml) intralesional after softening the site with light liquid nitrogen cryotherapy; CO2 laser vaporization followed by intralesional triamcinolone (5–10 mg per ml) or imiqui- mod 5% cream applied daily for 6–8 weeks; punch excision of individual papules; hori- zontal ellipical excision with or without primary closure References Gloster HM Jr (2000). The surgical management of extensive cases of acne keloidalis nuchae. Ar- chives of Dermatology 136:1376–1379 Acne keloidalis nuchae ᭤ Acne keloidalis PART1.MIF Page 8 Wednesday, October 29, 2003 4:13 PM Acne necrotica miliaris 9 A Acne medicamentosa Synonym(s) None Definition Acneiform eruption related to ingestion of a medication Pathogenesis Unknown; not an allergic reaction to the medication; not a variant of acne vulgaris Clinical manifestation Acute onset of inflammatory papules in the the same stage of development with few or no comedones; occurs on the chest, back, and upper extremities; causative agents include systemic corticosteroids, anabolic steroids, B vitamins, anticonvulsants, lith- ium, isoniazid, quinidine, azathioprine, cyclosporine, etretinate, and halides Differential diagnosis Acne vulgaris; folliculitis; chloracne; tropical acne; acne aestavalis Therapy Discontinue offending medication, if possible; tetracycline; tretinoin 0.025% cream References We bster, GF (2002) Acne. British Medical Journal 325:475–479 Acne necrotica Synonym(s) Acne necrotica miliaris; acne variolaformis; acne frontalis; acne atrophica; necrotizing lymphocytic folliculitis; pustular perifolliculitis Definition Papulopustular follicular eruption which heals with depressed scars Pathogenesis Genetic factors possibly operative Clinical manifestation Recurrent grouped perifollicular papules and pustules which heal with variolaform scars; most often located in the temporal scalp, but also on the face, chest, and back Differential diagnosis Bacterial folliculitis; tinea capitis; vasculi- tis; papulonecrotic tuberculid; hydroa vac- ciniforme Therapy Te t racycline; isotretinoin 1 mg per kg PO combined with prednisone 1 mg per kg per day PO ଙ ; antibacterial washes with chlo- rhexadine or hexachlorophene 2–3 times daily; daily shampooing References Kossard S, Collins A, McCrossin I (1987) Necrotiz- ing lymphocytic folliculitis: the early lesion of acne necrotica. Journal of the American Acade- my of Dermatology 16:1007–1014 Acne necrotica miliaris ᭤ Acne necrotica Acne Medicamentosa. Monomorphous red papules on the arm and lateral chest wall PART1.MIF Page 9 Wednesday, October 29, 2003 4:13 PM 10 Acne rosacea Acne rosacea ᭤ Rosacea Acne variolaformis ᭤ Acne necrotica Acne varus ᭤ Acne vulgaris Acne vulgaris Synonym(s) Acne varus Definition Common, self-limited eruption characterized by abnormal follicular keratinization, comedones, inflammatory papules, pustules, and nodular abscesses Pathogenesis Multiple contributing factors including inheritance, hormonal effects on follicles, increased sebum production, bacteria, abnormal follicular keratinization, and response to environmental stimuli such as oils and frictional trauma Clinical manifestation Closed comedones (whitehead); open comedones (blackhead); inflammatory papules and pustules; nodules; draining sinuses; postinflammatory scars; lesions in areas with abundant sebaceous follicles: face, back, upper chest wall Differential diagnosis Acne aestivalis; rosacea; perioral dermatitis; folliculitis; acne medicimentosa; occu- pational acne; tropical acne; acne cosmet- ica; syndrome of Favre-Racouchot; flat warts; trichostasis spinulosa Therapy Comedonal acne: tretinoin 0.025% cream or adapalene 0.1% gel or tazarotene 0.1% gel; alpha hydroxy acid preparation Inflammaroty acne: tetracycline or doxycy- cline or minocycline; benzoyl peroxide 5% gel; azelaic acid 20% cream; clindamycin 1% lotion or cream; erythromycin 2% gel or cream Recalcitrant acne in women: oral contracep- tive containing norgestimate 0.25 mg and ethinyl estradiol 0.035 mg; spironolactone; prednisone Acne where sweating is an aggravating factor: aluminium chloride solution Severe nodulocystic acne unresponsive to other therapies: isotretinoin ଙ Acne surgery: comedone expression; incision and drainage of fluctuant cysts and abscesses; chemical peel; microdermabra- sion; intralesional triamcinolone 2–4 mg/ml References We bster GF (2002) Acne vulgaris. British Medical Journal 325:475–479 Acoustic neuroma ᭤ Granular cell tumor Acquired digital fibrokeratoma Synonym(s) Garlic glove fibroma PART1.MIF Page 10 Wednesday, October 29, 2003 4:13 PM [...]... Differential diagnosis None Therapy Avoidance of situations where core body temperature may rise (exercise, sun exposure, etc.) References Tsuji T, Yamamoto T (19 76) Acquired generalized anhidrosis Archives of Dermatology 11 2 :13 10– 13 14 Acquired hypertrichosis Therapy Simple excisionଙ References Vinson RP, Angeloni VL (19 95): acquired digital fibrokeratoma American Family Physician 52 :13 65 13 67 Acquired epidermolysis... granuloma annulare; colloid milia Therapy Destruction with liquid nitrogen cryotherapy; CO2 laser or Nd:YAG laser; tretinoin 0.025% cream; adapalene 0 .1% gel References Chapman-Rolle L, DePadova-Elder SM, Ryan E, Kantor GR (19 94) Persistent flat-topped papules on the extremities Acrokeratosis verruciformis (AKV) of Hopf Archives of Dermatology 13 0(4):508–509, 511 – 512 Acrokeratosis verruciformis of Hopf... dermatitis Therapy Zinc dietary supplementation 1 mg per kg per day for life References References Melski JW (2000) Lyme borreliosis Seminars in Cutaneous Medicine & Surgery 19 :10 18 Radja N, Charles-Holmes R (2002) Acrodermatitis enteropathica: lifelong follow-up and zinc A 16 Acrodermatitis enteropathica-like syndrome monitoring Clinical & Experimental Dermatology 27:62–63 Acrodermatitis enteropathica-like... mucinosis Therapy Treatment of underlying vascular insufficiency: support hose; sequential compression device; Unna boots; leg elevation; weight loss; exercise program Surgical therapy: excision of individual lesions Therapy None References References Pires A, Depairon M, Ricci C (19 99) Effect of compression therapy on a pseudo-Kaposi sarcoma Dermatology 19 8:439–4 41 Flowers SL, Cooper PH, Landes HB (19 89)... viral meningitis Therapy Early disease: Suramin 10 0–200 mg IV test dose, then 1 g IV on days 1, 3, 7, 14 ଙ; eflornithine 400 mg per kg per day IV 4 times daily for 14 daysଙ Neurologic (late stage) disease: melarsoprol 2–3.6 mg per kg per day IV for 3 days; after 1 week, 3.6 mg per kg per day for 3 days; after 10 – 21 days, repeat cycle; eflornithine 400 mg per kg per day IV 4 times daily for 14 days References... occurring after abrupt discontinuance of prolonged sys- Don-Wauchope AC, Toft AD (2000) Diagnosis and management of Addison's disease Practitioner 244 (16 14):794–799 Addison-Schilder disease Synonym(s) Addison disease-cerebral sclerosis syndrome; Fanconi-Prader syndrome; SchilderAddison syndrome; Siemerling-Creutzfeldt syndrome; adrenocortical atrophy-cerebral sclerosis syndrome, adrenoleukomyelopathy;... after washing and drying skin Addison-Schilder disease Contraindications/precautions Hypersensitivity to drug class or component; caution in applying to eczematous skin References Wolf JE Jr (2002) Potential anti-inflammatory effects of topical retinoids and retinoid analogues Advances in Therapy 19 (3) :10 9 11 8 Addison disease ᭤ Addison’s 29 temic corticosteroid therapy; hypopituitarism Clinical manifestation... Signs and symptoms of systemic disease: ceftriaxone 2 g IV every 24 hours for 14 – 21 days; cefotaxime 1 2 g IV every 8 hours for 14 – 21 days; penicillin G 3–4 million units IV every 4 hours for 21 days 15 Acrodermatitis enteropathica Synonym(s) Acrodermatitis enteropathica; DanboltCloss syndrome; acrodermatitis enteropathica-like syndrome; transient symptomatic zinc deficiency; iatrogenic acrodermatitis... Ultraviolet-induced postinflammatory dermal connective tissue degeneration; relative contribution of UVB and UVA unclear Clinical manifestation Yellowish hue to the skin with irregular, firm papules giving the skin a chicken skin- Fenske NA, Hynes LR, Lober CW (19 98) Actinic elastosis (senile elastosis) In: demis DJ (ed) Clinical Dermatology Lippincott Williams and Wilkins, Philadelphia, Section 1 4– 41 pp 1 12 ... PO daily for 3 days Filariasis Strongyloidosis 15 mg per kg PO twice daily for 3 days 400 mg PO twice daily; 28–day cycle < 60 kg – 15 mg per kg PO twice followed by 14 -day rest period, for daily; 28–day cycle followed by 3 cycles 14 -day rest period, for 3 cycles 400 mg PO as single dose 15 mg per kg PO as single dose 200 mg PO twice daily for 3 days; 15 mg per kg PO twice daily for repeat in 2 weeks . Berger TG (19 95) Disseminated acanthamebiasis in patients with AIDS. A report of five cases and a review of the literature. Archives of Dermatology 13 1 (11 ) :12 91 12 96 PART1 .MIF Page 1 Wednesday,. exposure, etc.) References Tsuji T, Yamamoto T (19 76) Acquired generalized anhidrosis. Archives of Dermatology 11 2 :13 10– 13 14 Acquired hypertrichosis Definition Excess hair growth in androgen-independ- ent. bster, GF (19 99) Acne vulgaris. Archives of Dermatology 13 5 :11 01 11 02 Acne conglobata Synonym(s) Conglobate acne Definition Inflammatory disease characterized by cysts, double-headed comedones,

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