Chapter 105. Malignancies of Lymphoid Cells (Part 12) ppsx

Chapter 105. Malignancies of Lymphoid Cells (Part 12) Table 105- 10 Clinical Characteristics of Patients with Common Types of Non-Hodgkin's Lymphomas (NHL) Dis ease M edian Age, years Fre quency in Children Male S tage I/II vs III/IV, % B Sympt oms, % B one Marro w Involve ment, % Gastro intestinal Tract Involvement, % Survi ving 5 years B 6 Rar 9 3 7 3 cell chronic lymphocyt ic leukemia/ small lymphocyt ic lymphoma 5 e 3 vs 91 3 2 1 Ma ntle cell lymphoma 6 3 Rar e 4 2 0 vs 80 2 8 6 4 9 7 Ext ranodal marginal zone B cell lymphoma of MALT 6 0 Rar e 8 6 7 vs 33 1 9 1 4 50 4 type Fol licular lymphoma 5 9 Rar e 2 3 3 vs 67 2 8 4 2 4 2 Dif fuse large B cell lymphoma 6 4 ~25 % of childhood NHL 5 5 4 vs 46 3 3 1 6 18 6 Bur kitt's lymphoma 3 1 ~30 % of childhood NHL 9 6 2 vs 38 2 2 3 3 11 5 Pre cursor T cell lymphobla stic 2 8 ~40 % of childhood NHL 4 1 1 vs 89 2 1 5 0 4 6 lymphoma An aplastic large T/null cell lymphoma 3 4 Co mmon 9 5 1 vs 49 5 3 1 3 9 7 Per ipheral T cell non- Hodgkin's lymphoma 6 1 ~5 % of childhood NHL 5 2 0 vs 80 5 0 3 6 15 5 Note: MALT, mucosa-associated lymphoid tissue. The diagnosis of typical B cell CLL is made when an increased number of circulating lymphocytes (i.e., >4 x 10 9 /L and usually >10 x 10 9 /L) is found (Fig. 105-6) that are monoclonal B cells expressing the CD5 antigen. Finding bone marrow infiltration by the same cells confirms the diagnosis. The peripheral blood smear in such patients typically shows many "smudge" or "basket" cells, nuclear remnants of cells damaged by the physical shear stress of making the blood smear. If cytogenetic studies are performed, trisomy 12 is found in 25–30% of patients. Abnormalities in chromosome 13 are also seen. . Chapter 105. Malignancies of Lymphoid Cells (Part 12) Table 105- 10 Clinical Characteristics of Patients with Common Types of Non-Hodgkin's Lymphomas. "basket" cells, nuclear remnants of cells damaged by the physical shear stress of making the blood smear. If cytogenetic studies are performed, trisomy 12 is found in 25–30% of patients 6 1 ~5 % of childhood NHL 5 2 0 vs 80 5 0 3 6 15 5 Note: MALT, mucosa-associated lymphoid tissue. The diagnosis of typical B cell CLL is made when an increased number of circulating