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[...]... Simplex Virus 1 (HSV-1) for Glioblastoma Multiforme Therapy 1105 Costas G Hadjipanayis 47 The Development of Targeted Cancer Gene-Therapy Adenoviruses for High-Grade Glioma Treatment 1137 Dawn E Post and Erwin G VanMeir 48 Harnessing T-Cell Immunity to Target Brain Tumors 1165 Paul R Walker, Robert M Prins, Pierre-Yves Dietrich,... Farber Cancer Institute, Boston, MA, USA, alan_dandrea@dfci.harvard.edu Waldemar Debinski Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA, debinski@wfubmc.edu Pierre-Yves Dietrich Centre of Oncology, Geneva University Hospitals and University of Geneva, rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland, Pierre-Yves.Dietrich@hcuge.ch Terry Van. .. Germany, bernd.koelsch@uk-essen.de Serguei Kozlov Mouse Cancer Genetics Program, Centers for Cancer Research and Advanced Preclinical Research, National Cancer Institute, Frederick, MD, USA, kozlovse@mail.nih.gov Chien-Tsun Kuan Department of Pathology, 181C Medical Sciences Research Building, Duke University Medical Center, Box 3156, Durham, North Carolina 27710, kuan@duke.edu Chang-Hyuk Kwon Department... international cancer societies including the American Association for Cancer Research, the European Association for Cancer Research, and the American Society for Investigative Pathology Dr VanMeir currently serves on the Editorial Board of Neuro-Oncology, Frontiers in Bioscience, and International Journal of Oncology, and is a former Associate Editor of the International Journal of Cancer He has served... M.D Anderson Cancer Center, Houston, TX 77030, USA David Stokoe Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA, stokoe.david@gene.com Erik P Sulman Department of Radiation Oncology, The University of Texas M.D Anderson Cancer Center, Houston, TX, USA Erwin G VanMeir Department of Neurosurgery, Hematology and Medical Oncology, and Winship Cancer Institute,... Switzerland, Pierre-Yves.Dietrich@hcuge.ch Terry Van Dyke Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA; Mouse Cancer Genetics Program, Centers for Cancer Research and Advanced Preclinical Research, National Cancer Institute, Frederick, MD, USA, vandyket@mail.nih.gov Burt G Feuerstein Barrow Neurological Institute, St Joseph’s Hospital and Medical... University of Texas M.D Anderson Cancer Center, Houston, TX, USA, gfuller@mdanderson.org Frank B Furnari Ludwig Institute for Cancer Research, Department of Medicine, Cancer Center, University of California-San Diego, La Jolla, CA 9209 3-0 660, USA, ffurnari@ucsd.edu Elizabeth R Gerstner Division of Hematology and Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center and Harvard Medical... Carolina 27710, bigne001@mc.duke.edu Oliver Bogler Department of Neurosurgery and Department of NeuroOncology, Brain Tumor Center, University of Texas M.D Anderson Cancer Center, Houston, TX 77030, USA, obogler@mdanderson.org Jean-Louis Boulay Laboratory of Neuro-Oncology, Department of Biomedicine and Neurosurgery, University Hospital, CH-4031 Basel, Switzerland, jean-louis.boulay@unibas.ch Susan T... Understand Human Pediatric Low-Grade Gliomas David H Gutmann 45 3 4 Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role of p21-Ras in Glioblastoma Multiforme Diana Munoz, Sameer Agnihotri, and Abhijit Guha 5 Pten-Deficient Mouse Models for High-Grade Astrocytomas Chang-Hyuk Kwon 6 The Nf1–/þ;Trp53–/þcis... region of contrast enhancement and region of highest relative cerebral blood volume (rCBV), suggesting that contrast-enhancing region is the most aggressive portion of tumor, in a 37-year-old man with biopsy-proved World Health Organization grade III astrocytoma (a) Axial contrast-enhanced T1-weighted image shows inhomogeneously enhancing mass in the right frontal lobe Contrast enhancement is confined . Switzerland, Pierre-Yves.Dietrich@hcuge.ch Terry Van Dyke Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA; Mouse Cance r Genetics Program, Centers for Cancer Research. discovery of life-saving medicines. Novel targeted therapeutics and biomarker-based imaging will benefit in the near future from the emergence of nanotechnology. Independently, the last decade has brought. with anti-VEGF antibodies. ix Subsequent breakthroughs have included the sequencing of the human genome in 2003 and the use of new techniques that permit whole-genome analyses for gene expression