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CHAPTER ENZYME CONTENTS Nomenclature and Classification Mechanism of enzyme action Catalytic mechanism Enzyme activity Factors influence on enzyme activity Enzyme Kinetics Enzyme production 04/06/2023 ENZYME NOMENCLATURE Traditional name: some of the earliest enzymes to be discovered: Name: ending in – “in” to indicate they were proteins Ex: the digestive enzymes: pepsin, trypsin, chymotrypsin 04/06/2023 ENZYME NOMENCLATURE Common name Substrate/ activity + ase Examples: urease catalyzes hydrolysis of urea DNA polymerase catalyzes the polymerization of nucleotides to form DNA 04/06/2023 EXAMPLES 04/06/2023 ENZYME NOMENCLATURE EC (Enzyme Commission) systematic name: [International Union of Biochemistry and Molecular Biology: IUBMB] Systematic name indicating: The substance acted on The functional group acted on The type of reaction catalyzed All EC names end in –ase 04/06/2023 ENZYME NOMENCLATURE Systematic name: encoded by a four-digit classification number Ex: EC number: 2.7.1.1.: (2) : the class name (transferase) (7): the sub class (phosphotransferase) (1): the sub sub class (a phosphotransferase with a hydroxyl group as acceptor) (1): the sub sub sub class (D-hexose as the phosphoryl group acceptor) 04/06/2023 EC CLASSIFICATION OF ENZYMES Enzymes: grouped into major classes (based on the rxns which they catalyze) 04/06/2023 ENZYME CLASSIFICATION 04/06/2023 ENZYME CLASSIFICATION 04/06/2023 10