[...]... Philipps-Universität Marburg Karl-von-Frisch-Straße 8b 35043 Marburg Germany Handbook of Genome Research Genomics, Proteomics, Metabolomics, Bioinformatics, Ethical and Legal Issues Edited by Christoph W Sensen Copyright © 2005 WILEY-VCH Verlag GmbH & Co KGaA, Weinheim ISBN: 3-5 2 7-3 134 8-6 XXII List of Contributors Jian Chen Bristol Myers Squibb Pharmaceutical Research Institute 311 Pennington-Rocky... sometimes unexpected findings of this project Special emphasis is given to genomic data which Handbook of Genome Research Genomics, Proteomics, Metabolomics, Bioinformatics, Ethical and Legal Issues Edited by Christoph W Sensen Copyright © 2005 WILEY-VCH Verlag GmbH & Co KGaA, Weinheim ISBN: 3-5 2 7-3 134 8-6 4 1 Genome Projects in Model Organisms support the understanding of general features such as translation... Christoph W Sensen Copyright © 2005 WILEY-VCH Verlag GmbH & Co KGaA, Weinheim ISBN: 3-5 2 7-3 134 8-6 3 1 Genome Projects on Model Organisms Alfred Pühler, Doris Jording, Jörn Kalinowski, Detlev Buttgereit, Renate Renkawitz-Pohl, Lothar Altschmied, Antoin Danchin, Agnieszka Sekowska, Horst Feldmann, Hans-Peter Klenk, and Manfred Kröger 1.1 Introduction Genome research enables the establishment of the complete... Bielefeld Germany Renate Renkawitz-Pohl Fachbereich Biologie, Entwicklungsbiologie Philipps-Universität Marburg Karl-von-Frisch-Straße 8b 35043 Marburg Germany List of Contributors Peter Rice European Bioinformatics Institute Wellcome Trust Genome Campus Hinxton Cambridge, CB10 1SD UK Tracey Rigby MicroArray Laboratory National Research Council of Canada Biotechnology Research Institute 6100 Royalmount... Paris Cedex 15 France Christoph W Sensen Faculty of Medicine Sun Center of Excellence for Visual Genome Research University of Calgary 3330 Hospital Drive NW Calgary Alberta, T2N 4N1 Canada Lorraine Sheremeta Health Law Institute at the University of Alberta University of Alberta 402 Law Centre Edmonton Alberta, T6G 2H5 Canada Julie Stromer University of Calgary Department of Biochemistry and Molecular... Yeast Two-hybrid System 262 Variations of the Two-hybrid System 263 The Reverse Two-hybrid System 263 The One-hybrid System 264 The Repressed Transactivator System 264 Three-hybrid Systems 264 Membrane Yeast Two-hybrid Systems 265 SOS Recruitment System 266 Split-ubiquitin System 266 XIII XIV Contents 11.4.3 11.4.4 11.4.5 11.5 11.6 G-Protein Fusion System 266 The Ire1 Signaling System 268 Non-yeast Hybrid... The E coli genome project is described by M KRÖGER (Giessen, Germany) He gives an historical outline of the intensive research on microbiology and genetics of this organism, which cumulated in the E coli genome project Many of the technological tools currently available have been developed during the course of the E coli genome project E coli is without doubt the best-analyzed microorganism of all The... Department of Biochemistry McGill University 3775 University St Montreal Quebec, H3A 2B4 Canada Manfred Kröger Institut für Mikro- und Molekularbiologie Justus-Liebig-Universität Heinrich-Buff-Ring 2 6-3 2 35392 Giessen Germany Sheena Lambert Department of Biochemistry and Molecular Biology University of Calgary 3330 Hospital Drive N.W Calgary Alberta, T2N 4N1 Canada David Michels Department of Chemistry... Department of Chemistry University of Washington Seattle Washington, 9819 5-1 700 USA Edna Einsiedel University of Calgary 2500 University Drive N.W., SS318 Calgary Alberta, T2N 1N4 Canada Peter J Facchini Department of Biological Sciences University of Calgary 2500 University Drive N.W Calgary Alberta, T2N 1N4 Canada Abul Fazal Department of Chemistry University of Washington Seattle Washington, 9819 5-1 700... Horst Feldmann Adolf-Butenandt-Institut für Physiologische Chemie der Ludwig-Maximilians-Universität Schillerstraße 44 80336 München Germany Greg Finak Department of Biochemistry McGill University 3775 University St Montreal Quebeck, H3A 2B4 Canada Andreas Freier Department of Bioinformatics / Medical Informatics Faculty of Technology University of Bielefeld 33501 Bielefeld Germany List of Contributors . 3-5 2 7-3 134 8-6 Handbook of Genome Research Edited by Christoph W. Sensen T. Lengauer, R. Mannhold, H. Kubinyi, H. Timmermann (Eds.) Bioinformatics From Genomes to Drugs 2 Volumes 2001, ISBN 3-5 2 7-2 998 8-2 A.D 3-5 2 7-3 038 0-4 Further Titles of Interest Handbook of Genome Research Edited by Christoph W. Sensen Genomics, Proteomics, Metabolomics, Bioinformatics, Ethical and Legal Issues Edited by Prof 97 8-3 -5 2 7-3 134 8-8 ISBN-10: 3-5 2 7-3 134 8-6 V Life-sciences research, especially in biology and medicine, has undergone dramatic changes in the last fifteen years. Completion of the sequencing of the first