Placental Bed Disorders Basic Science and its Translation to Obstetrics potx

[...]... diabetes mellitus, obesity, and hypertension may have their origins in abnormal placental development This is the first book devoted exclusively to the anatomy, physiology, immunology, and pathology of the placental bed Experts in clinical and basic sciences have made important contributions to bring, in a single volume, a large body of literature on the normal and abnormal placental bed Thus, readers will... persisted, and in particular the understanding of the anatomical structure of the ‘curling’ arteries remained incomplete and often not based on data Therefore as an introduction to the chapters on placental bed vascular disorders the early literature on the maternal blood supply to the placenta is briefly reviewed The term placental bed was introduced 50 years ago by Dixon and Robertson [2] and can be... that the placental bed is such a battlefield that fetal and maternal tissues are hard to distinguish on biopsy material and maternal vessels are disrupted after placental separation In 1958, independent from the British group in Jamaica, the Department of Obstetrics and Gynaecology of the Catholic University of Leuven had also started to collect placental bed biopsies, and in 1963 they began to collect... re-examination of the original histological sections of Hertig and Rock [17] cast doubt on the drawings published by these authors in 1941 and the existence of such shunts was later disproved Recently, Schaaps and collaborators [19] used threedimensional sonography and anatomical reconstruction to investigate the placental bed vasculature and demonstrated an extensive vascular anastomotic network in the myometrium... Belgium Contributors Leslie Proctor Department of Obstetrics and Gynecology Mount Sinai Hospital Toronto, Ontario, Canada Robert N Taylor Department of Gynecology and Obstetrics Emory University School of Medicine Atlanta, USA Sarosh Rana Obstetrics and Gynecology Maternal Fetal Medicine Division Beth Israel Deaconess Medical Center Boston, MA, USA May Lee Tjoa Division of Molecular and Vascular Medicine... abruptio placentae, and fetal death These clinical disorders (referred to as ‘obstetrical syndromes’) are the major complications of pregnancy and leading causes of perinatal and maternal morbidity and mortality Moreover, recent evidence indicates that these disorders have the potential to reprogram the endocrine, metabolic, vascular, and immune responses of the human fetus, and predispose to adult diseases... of Obstetrics and Gynecology University Hospital Gasthuisberg Leuven, Belgium Guy St J Whitley Division of Basic Medical Sciences St George’s, University of London London, UK xi Preface The role of the placental bed in normal pregnancy and its complications has been intensively investigated for 50 years, following the introduction of a technique for placental bed biopsy It is now recognized that disorders. .. informative, well-illustrated, and scholarly contributions in the cell biology of the placental bed, immunology, endocrinology, pathology, genetics, and imaging The aim of the book is to inform the reader about the exciting developments in the study of the placental bed as well as the novel approaches to the assessment of this unique tissue interface and its implications for the diagnosis and treatment of complications... In the initial studies of placental bed uteroplacental arteries in preeclampsia Dixon and Robertson [2] and Brosens [3] assumed that the response of the arteries to placentation was similar to that in normal pregnancy and the investigators were looking for typical hypertensive vascular lesions However, after the identification of the physiological changes in the placental bed spiral arteries [4] (Fig... arteries in the placental bed in association with preeclampsia and fetal growth restriction and the methodology of placental bed vascular studies are reviewed Defective myometrial spiral artery remodeling in preeclampsia Research on the presence and extent of physiological changes in the spiral arteries in the subendometrial myometrium was based on 15 hysterectomy specimens and over 300 placental bed biopsies .