impact of pneumococcal conjugate vaccine in children on the serotypic epidemiology of adult invasive pneumococcal diseases in taiwan

Accepted Manuscript Impact of pneumococcal conjugate vaccine in children on the serotypic epidemiology of adult invasive pneumococcal diseases in Taiwan Hsiao-Chun Chi, Yu-Chia Hsieh, Ming-Han Tsai, Chen-Hsiang Lee, Kuang-Che Kuo, Ching-Tai Huang, Dr Yhu-Chering Huang PII: S1684-1182(16)30144-X DOI: 10.1016/j.jmii.2016.08.009 Reference: JMII 791 To appear in: Journal of Microbiology, Immunology and Infection Received Date: 30 April 2016 Revised Date: 19 July 2016 Accepted Date: August 2016 Please cite this article as: Chi H-C, Hsieh Y-C, Tsai M-H, Lee C-H, Kuo K-C, Huang C-T, Huang Y-C, Impact of pneumococcal conjugate vaccine in children on the serotypic epidemiology of adult invasive pneumococcal diseases in Taiwan, Journal of Microbiology, Immunology and Infection (2017), doi: 10.1016/j.jmii.2016.08.009 This is a PDF file of an unedited manuscript that has been accepted for publication As a service to our customers we are providing this early version of the manuscript The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain ACCEPTED MANUSCRIPT Impact of pneumococcal conjugate vaccine in children on the serotypic epidemiology of adult invasive pneumococcal diseases in Taiwan Hsiao-Chun Chi1, Yu-Chia Hsieh1,2, Ming-Han Tsai2,3, Chen-Hsiang Lee2,4, KuangChe Kuo2,5, Ching-Tai Huang2,6, Yhu-Chering Huang1,2* Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, RI PT Taiwan Chang Gung University College of Medicine, Taoyuan, Taiwan Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, SC Taiwan Department of Internal Medicine, Chang Gung Memorial Hospital at Kaohsiung, M AN U Kaohsiung, Taiwan Department of Pediatrics, Chang Gung Memorial Hospital at at Kaohsiung, Kaohsiung, Taiwan, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, TE D EP Running title: Impact of PCV on adult IPD in Taiwan AC C *Corresponding author: Dr Yhu-Chering Huang, Department of Pediatrics, Chang Gung Memorial Hospital, Number 5, Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan Tel: 886-3-3281200, Fax: 886-3288957 E-mail address: ychuang@cgmh.org.tw ACCEPTED MANUSCRIPT Abstract Background: Invasive pneumococcal disease (IPD) cause significant morbidity and mortality, especially in children and older adults Pneumococcal 7-valent and 13valent conjugate vaccine (PCV-7 and PCV-13) were introduced in Taiwan in 2005 RI PT and 2011 for children This study was conducted to evaluate the impact of PCV administered in children on adult invasive pneumococcal disease Methods: From the logbooks of microbiology laboratories, we retrospectively SC retrieved Streptococcus pneumoniae isolates, collected from normally sterile sites in adult patients 157 consecutive, non-duplicated isolates were collected from one M AN U hospital during 2001 and 2003 (pre-PCV period) and 150 isolates from three hospitals from July 2011 to June 2015 (post-PCV period) Serotypes were determined by Quellung test Results: Among the 307 isolates, a total of 31 serotypes/serogroups were identified TE D PCV-7 serotypes, particularly types 14 (31.2%), 23F (19.7%) and 6B (12.7%) dominated in the pre-PCV period (78.3%) but significantly decreased in the post-PCV period (36%) (P < 0.01) PCV-13 specific serotypes (PCV13-PCV7) significantly EP increased from 7% of the isolates in the pre-PCV period to 28.7% of the isolates in AC C the post-PCV period (p