1298 In Vivo Imaging Detects Tc 99m Labeled Ad Redirected to Lung Following Intravenous Dosing Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Thera[.]
!!"7 " "!"! -?C2 / C(.8" =5 A G ? " 8: 3 -?$ / 3 H$% @ 7 - -( " 7H0"" / *,' 3 ?'( ,&H ?D4 3 8 3 - G :"89 / :8,389 ;±8;9, -!O99&/ 8;8389B±&B ( !> ?C2 H$% 9B&:±99,& - / 98,5±99,= - / ?$ !> -6&8±9,&/ -6B&±9,,/ @ $ ?D4 89B389;±8=,B 88 $ . " ?D4 . C(.8" 7H0 ? !> ?$ . 3 C(.8" 7H0 7 G -C(.8" 7H0 / 3 !> $ > 3 2" > #'@ ? 3 > > #'@ ,"= ?! -#?/ 2" -*"B@>C @' #'@"! A 3 6 " ' 8&H $*' & ! A 3 -#? &8";8/ ,",6 > "! A ," ?! 3 2" - / 8 = & B > #'@"! A ="89 3 2" -#? =&&"B9B/ " -#? 6;";6/ ? ?! 2" 3 3 > > #'@ 3 2" > 2" " 3 1298 c-99m-Labeled Ad Vivo Tc-99m-Labeled In V ivo Imaging Detects T Redirected to Lung Following Intravenous Dosing 1297 Regulated T ransgene Expression in BTransgene Lymphocytes from Lentiviral V ectors Carrying the Vectors Immunoglobulin Heavy Chain Enhancer with Matrix Attachment Regions Carolyn Lutzko,1 Dinithi Senadheera,1 Diane Skelton,1 Denise Petersen,1 Donald B Kohn.1 Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA, United States D -C( / ( 1 3 C( 1 3 2" C # 3 2" 3 ! A G (* " 2" 3 -> / 3 -> #'@/ ! A #. - 3 ?!/ S424 K R Zinn,1 T R Chaudhuri,1 V N Krasnykh,2 D T Curiel,2 P N Reynolds.2 Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, United States; 2Department of Medicine, Pathology, and Surgery, Division of Human Gene Therapy; and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, United States ( +(9 E -' / ' # ' 0 " ' 3 ? ' E 3 "55 ' B"C 3 ' B"C E "55" ' E )9 ' "55-/ 0 -* 2 8;7 :5;"5988555/ ' "8 ? 6 "55" ' =9 525 E ' " G -'>/ - @ *2 857:=:" :6, ,998/ "55" ' -8=38988 % / Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy " 7 " " !"! E E -M=% / 1 89 -M=/ E "55"#'' E "55" )*)9 "55" ' E '>" E 68±9; H E -H $/ -O99&/ 95±9, H $ '>" E * G =6±95 H $% 9;±98 H $% D ::±9:H$% 59±9=H$% H ' "55"#'' "55" (*)+()9 3 E "55" ' ? ' 3 1299 Control of Immune Responses to Gene Therapy: A Human CD80 Enhancer/Promoter Construct Enables Specific Ablation of Gene-T ransfected Antigen Gene-Transfected Presenting Cells In Vitro Yuanfang Liu,1 John R Rodgers.1 Immunology, Baylor College of Medicine, Houston, Texas, United States @ G 3 " -'!/ ' 3 '! '!" 3 3 ' -$ '/ '! " ->/ " -!/ $:9 -2;8/ 3 " $:9!>" ? ! -> ?!/ $ ' 3 $:9" -',9/ -@E >"$ ' ->?,/ 3 " ,5= >?, ,5= 3 3 ,5=">?, ' "$:9%$ ' 4 " ' " $:9!>%$ ' 3 3 $:9 ,5=%>?, $ '" 3 " ' "$:9!> " 7 " " !"! 1300 Lentiviral V ectors Utilizing the Chicken β-Globin Vectors 5′HS4 Insulator and the Human Interferonα Scaffold Interferon-α Attachment Region for High Level and Sustained Factor VIII Gene Expression Ali Ramezani,1 Teresa S Hawley,1 Robert G Hawley.1 Hematopoiesis, American Red Cross Holland Laboratory, Rockville, Maryland, United States C ' .-./ 8"&H . " 3 . 1 ' ' -C(/ . @ - / C( C E " " " $*' 3 " 3 β" &VC(6 "α -?*"('@/ G -@ G # ,76:&"65B ,999/ ->?8α/ -4= #(. D @/ -' / 3 -> ?!/ 3 $=6J A 8( " " G > ?! 3 ) &VC(6 ?*"('@ 3 #(. 4= D @ 1 1 $=6J % ( A 8 3 > ?! 2 &VC(6 ?*"('@ 3 " . $*' C( ." D" . 3 1301 T ransgenesis by Lentiviral V ectors: Lack of Transgenesis Vectors: Gene Silencing in Mammalian ES Cells and Preimplantation Embryos Alexander Pfeifer, Masahito Ikawa, Yelena Dayn, Inder M Verma @ ->(/ C 3 ? " -?'(/ 3 86 >( ?! 3 ' -D." ?!/ ?! 3 5&&H > D." ?! >( 3 ?! 3 3 " Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy S425