1164 19F NMR Analysis of 5 Fluorocytosine Metabolism in Cytosine Deaminase Transfected Dunning R3327 AT 1 Rat Prostate Cells; Failure of the Bystander Effect Molecular Therapy Vol 5, No 5, May 2002, P[.]
"? "? 1162 Development of HIV -Derived Lentiviral V ectors HIV-Derived Vectors for Gene Therapy of Hepatocellular Carcinoma Rathviro Uch,1,4 René Gérolami,1,3,4 Jean Hardwigsen,3 Jorge Cardoso,2 Franck Dodero,4 Sylvie Mathieu,4 Claude Bagnis,1 Christian Bréchot,2 Patrice Mannoni.1 Département de Thérapie Cellulaire et Gộnique, Etablissement Franỗais du sang Alpes Mộditerranộe, Marseille, France; INSERM U370, Paris, France; 3Service d′Hépatologie, Hôpital de La Conception, Marseille, France; 4INSERM U559, Marseille, France C C C." > ?! DN -#./ -! A/ " #. -' / " -0!@>/ " ? ' ?! 3 C ! A #. # 0!@> ?! 3 - 8& 89 / ?! 3 C." - ?!/ ?! 3 - ?!/ C ' ?! 1 -:=H ± 89/ C - :5H ± ,/ ?! -,=H ± 6/ C -5;H ± B/ # E " C - $>*/ C." C C." -C(." / ?! - A/0 C A 3 . ( E D A . ) E A $>* -&": / 1 # D A E ." ' C." C 1163 Directed In V ivo Evolution of Retroviruses Vivo Activatable by T umour-Associated Matrix Tumour-Associated Metalloproteases R Schneider,1 Y Medvedovska,1 B Voelker,1 M Chadwick,2 S Russel,3 C Buchholz,1 K Cichutek.1 Medical Biotechnology, Paul-Ehrlich-Institut, Langen, Germany; BioFocus PLC, Cambridge, United Kingdom; 3Molecular Medicine Program, Mayo Clinic, Rochester, MN, United States # 3 -##! / ##! ->/ -#D./ -> ?/ " C ##!", 1 !, S378 !,′ !=′ 3 ##!", ! C 89:9 != !8 !8′ 1 C 89:9 " 3 89= ##!", ##! 1164 19F-NMR Analysis of 5-Fluorocytosine Metabolism ransfected Dunning R3327 AT-1 Deaminase-Transfected in Cytosine Deaminase-T Rat Prostate Cells; Failure of the Bystander Effect Heike Corban-Wilhelm,1 William E Hull,2 Juergen Debus.1 Radiation Oncology, German Cancer Research Center, Heidelberg, Germany; 2Central Spectroscopy, German Cancer Research Center, Heidelberg, Germany ' % " -2>/ 899H -$/ G 3 $ "3 &" -&"?/ &" -&"?4/ -?4 ! ? 4#!/ &"?4 - / E 3 -2>/ 85 ?"*#@ 3 $" &"? &"?4 3 &"?40 E 2> + * > ) $ @==,; ' "8 -$ A/ "# - A/ C(."8 ' "8%$ A =:; ;;6μ# &"? 6 8B C -L89:/ 6U C>!>(%@ 8 85?"*#@ 6;9 #CG -88; / 6U -2 '#"&99 / 2> ' "8 ' "8%$ A 3 &" ? &9 # ( -! / 5B )*) &9 &"?4 &"? =μ# =8 # ' "8 =μ# ;:μ# ' "8%$ A 85?" *#@ ' "8%$ A &"?&"?4 8:6B8 ,5μ# 6 ;;6 μ# &"? ' 8B =86&, 8B=μ# &"?4 LBμ# 8B -O8μ#/ 6 ( 8B =:;μ#&"?-L=, μ# &"?4 L& μ# / 3 " =::μ# &"? I ;;& μ# &"? 899H' "8%$ A -B;H 5B /I =::μ# &"? (*)+() 3 3 2> > &"? &9 $" ' "8%$ A 85?"*#@ &"? &"?4 3 3 &"?4 - " 3 M Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy "? B":/ C" ? &"? 1 3 &"?4-T&9/ &"?4 1 2> 1165 Hypoxia Driven Gene Therapy T oT arget To Target umours Tumours Radiation Resistant T Rachel L Cowen,1 Naomi Chadderton,1 Kaye J Williams,1 Adam V Patterson,2 Brian A Telfer,1 Ian J Stratford.1 Department of Pharmacy, University of Manchester, Manchester, United Kingdom; 27Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand C3 3 3 3 !6&9 -!6&9@/ G @(489B5 G 3 3 -! A/ 3 -C@> / ? ! A%!6&9@ 3 -! ,99, / C 899H C@>%!6&9@ 3 G 3 C@> ' -D$C/ ! A 4 3 ! A D$C D$C 3 - 3 O 8 3 / 8H 3 ! A D$C -& / 8H 3 3 3 3 3 2 D$C ! A 3 1166 Selective Killing of Cancer Cells through Translational Regulation of the HTK/GCV Gene Therapy System Robert DeFatta,1 Robert Chervenak,1 Arrigo DeBenedetti.1 LSUHSC '#7$ 3 % ?6> #> C)$(7 C - A/ $*' 2A"( -2A" A/ ' ?6>" 3 - ##=# #?89'/ A -2A"4 A / 6 = -#?; #$',=8#$'6=&/ 8 -##,# /0 ?6> 3 A @*' . . E 2A" A" 2A"4 A" ' $*' E ' 3 . @>(4D (7> A 3 Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy 2A" A 3 2A"4 A " 3 ?6> A 2A"4 A" 3 2A" A" 2A" A" A 3 A 3 3 2A"4 A ,99 . 3 2A"4 A D 3 ?6> @*' ##,# - / A 3 . 1 . 2A" A 3 ) 2A"4 A . 3 )*D4()*(7 3 @ B* (? + ( *"'#,: G β" - 4( / -$ 2 < / ' G 1 ' %,: 4( ' G - ).'@"= ' %,: 4( "3 S379 ... '' ?! 1 -:=H ± 89/ C - :5H ± ,/ ?! ... -,=H ± 6/ C -5; H ± B/ # E