1148 Adenoviral Vascular Endothelial Growth Factor (VEGF A) Gene Transfer Stimulates Bone Injury Healing Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of[.]
" #( #( 3 4 $ 3 3 - / 3 #( 1146 Immunosuppression Impact on the Ectopic Bone Formation Induced with hBMP-4 and hBMP-9 Adenoviruses Jin Zhong Li,1 Hong Wei Li,1 Gerald R Hankins,1 Brad A Dunford,1 Gregory A Helm.1,2 Neurosugery, University of Virginia, Charlottesville, VA, United States; 2Biomedical Enginnering, University of Virginia, Charlottesville, VA, United States ,9 -2#!/ I 2#!",2#!"62#!"B2#!"; 2#!"5 ? 2#! 2#! ( ' $6 $: 3 " ( "$ 8/ 2#!"6 2#!"5 I ,/ 'I =/ ' 2#!"6 2#!"5 I 6/ " $6 $: -89% /I &/ " $6 $: 3 2#!"6 2#!"5 ' -89% / E , = 2#!"6 -,P89: !?4% / 2#!"5 -;&P89; !?4% / E 8 = 6 & 2 ' E 8 6 E $= $6 $: G & ,5= ?! 6 E $=$6 $: E $: G & 6 E =:8 8 ,9 ,=6: = ,9 6 88& & 2#!"5 9,5, = 8 98B: = = 9&:: = & 2#!"6 * , 6 ' G 2#!"5 $6 $: C 2#!"6 Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy 1147 Construction of [E1-,E2b-] Adenoviral V ectors Vectors with Human Bone Morphogenetic Protein -4 and -6 and Their Ability to Induce Ectopic Bone Formation in Rats Hongwei Li,1 Jinzhong Li,1 Andrea Amalfitano,3 Gerald R Hankins,1 Gregory A Helm.1,2 Department of Neurosurgery, University of Virginia, Charlottesville, VA, United States; 2Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 3Departments of Pediatrics and Human Genetics, Duke University Medical Center, Durham, NC, United States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denoviral V ascular Endothelial Growth Factor Vascular (VEGF-A) Gene T ransfer Stimulates Bone Injury Healing Transfer Tatu Tarkka,5 Annina Sipola,2 Timo Jämsä,3 Ylermi Soini,4 Seppo Ylä-Herttuala,6 Juha Tuukkanen,2 Timo Hautala.1 Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland; 2Department of Anatomy, University of Oulu, Oulu, Finland; 3Department of Medical Technology, University of Oulu, Oulu, Finland; 4Department of Pathology, University of Oulu, Oulu, Finland; 5Department of Surgery, University of Tampere, Tampere, Finland; 6A.I.Virtanen Institute of Molecular Sciences, University of Kuopio, Kuopio, Finland . -.> ?/ > ? G S373 "" > ? E > ?"' -= / 3 & , 89 89 ' ".> ?"' ' N- / E 89 8 , 6 3 6 H ? -2#/ 1 -S / ( &: H 2# > ? - O 9998/ 89 H " " & .> ? G* ?. ;6±,6.> ? &&±8; - O 999B/ ' - O 9996/ > ?" E > ?"' "" 1149 HIV V ector-Mediated Gene T ransfer of Vector-Mediated Transfer Angiostatin Inhibits Synovial Cell Proliferation and Angiogenesis of Collagen Induced Mouse Model Ko Kato,1,2 Koichi Miyake,1 Noriko Suzuki,1 Manami Okabe,1 Tutomu Igarashi,1 Masakazu Nagashima,2 Shinichi Yoshino,2 Takashi Shimada.1 Biochemistry and Molecular Biology, Nippon Medical School, Sendagi, Bunkyo-ku, Tokyo, Japan; 2Joint Disease and Rheumatism, Nippon Medical School, Sendagi, Bunkyo-ku, Tokyo, Japan @ -@'/ " 3 ' 3 D"8 ' G @' C. >3 * " E ? E E E -! / E -( / A E ,"= E 3 E ?! $ ) E * " G E % ' S374 1150 Expression and Safety of tgAA V-ratTNFR:Fc tgAAV after Local Intra-Articular Delivery Lauren M Tatalick,1 Tara Allen,1 Dana Martin,1 Elise Mebel,1 Linda Wilson,1 Bobby Joe Payne,2 Christopher Stewart,2 Carmel Lynch.1 Targeted Genetics Corporation, Seattle, WA, United States; Redfield Laboratories, Redfield, AR, United States - *?/ 3 D *? 3 ''." *?@7? ''. *? 3 *? ''." *?@7? " E " E D D ( -(0/" @ " ''." *?@7? ( $ 8 (0" 3 E @*' @ "!@ *?@7? >D(' ( 6 =9 59 - / 6 =9 -(0" / @*' E E 6 =9 B9 59 * *?@7? 6 =9 59 @*' E E 6 =9 *?@7? 6 ' =9 " 8%89 *?@7? *3 (0" " ''." *?@7? 3 *?@7? 3 1151 Depletion of Collagen II-Reactive T Cells and Blocking of B-Cell Activation Prevents Collagen IIInduced Arthritis in DBA/1j Mice Huang-Ge Zhang,1 Pingar Yang,1 Jinfu Xie,1 Zhongyu Liu,1 Di Liu,1 Liang Xiu,1 Tong Zhou,1 Yongming Wang,1 Hui-Chen Hsu,1 David T Curiel,1 John D Mountz.1 Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, United States -/" $2'%8E " " 2 " " 3 ? 3 " 3 =& "'!"' ? D=& ' # '-&3895 / ? ′ E "'!"' ? D=& ' # ' " " E " -).'/ "'!"' ? D=& ' # ' " " " " " Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy ... 1146 Immunosuppression Impact on the Ectopic Bone Formation Induced with hBMP-4 and hBMP-9 Adenoviruses Jin Zhong Li,1 Hong Wei Li,1 Gerald R