1. Trang chủ
  2. » Tất cả

1102 lung permeability induced by adenovirus mediated vascular endothelial growth factor (VEGF) gene transfer is mediated via direct endothelial activation by VEGF

2 4 0

Đang tải... (xem toàn văn)

THÔNG TIN TÀI LIỆU

1102 Lung Permeability Induced by Adenovirus Mediated Vascular Endothelial Growth Factor (VEGF) Gene Transfer Is Mediated Via Direct Endothelial Activation by VEGF Molecular Therapy Vol 5, No 5, May 2[.]

  ,5::B  $ "8@*'%μ@*''               $ "8           $ "8          !>                 $ "8             -?@/ =                    %            -O99&/ ?@                   -T989/ '                                                      $ "8                   1100 Cytokine Modulation of Endothelial Cell-Surface Coxsackie Adenovirus Receptor (CAR) Expression Theresa Vincent,1,2 Rebecca L Wendland,1 Ralf F Pettersson,2 Ronald G Crystal,1 Philip L Leopold.1 Weill Medical College of Cornell University, New York, NY, United States; 2Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden                                             3                            '                                              '    -' /                                                       "                   "              G    '                                       '                      3        3           -'@/     G                                                        *?αD"8β ?*γ' 6:              '             " E  '       '@ 3                   '@                 3       ' β        β"     '                                              '@                      -899H/ '@                  *?α -8,H/ ?*γ -6:H/   D"8β -=5H/              '@    7 *?α%?*γ -98H/ *?α%D"8β -;H/ ?*γ%D"8β -9BH/  *?α%?*γ%D"8β -96H/ $    '      '@ 3                       ' "       3  0  6:           *?α   ?*γ  1      ' β     9:H β"    3          -899H/      ' "      3            ;  :   3                '@                      '@       "                                '    "    '@                                            '@                     '                           $      1        #    "   -*'($'S 7 *./            (   @    '        '  8 855:      4      = "/      ->8"%>6"/   "       &      3 $*'- *"8 *", *   /-M6 %  / '         ,9 μ  !2(               #    -β"   /                                  :9H           &9H         "    "            "           -           !  /     "            -23/ D                       G            !    ,99H               G      ,&   ->,99/                   '            *"8  *",           - /-> ,997 =66±9,, =B,±96&   &;&±9=& %    O99&          /         *               ->,997 B,&±9,&% M 99;   / C         *                       *" 8    *",                                                       "       "             E                                  1102 Lung Permeability Induced by AdenovirusMediated V ascular Endothelial Growth Factor (VEGF) Vascular Gene T ransfer Is Mediated V ia Direct Endothelial Transfer Via Activation by VEGF Robert J Kaner,1 Ronald G Crystal.1 Weill Medical College of Cornell University, New York, NY, United States                                         3                             S357             C                            3                           ) 3    >?8B&    &;2B                    >8" >=" ' >?           -895 /             G        ""                             G                     >?8B&                                  G     >?8B&              >?"                               6,%66        -#'!/                                            >?8B&               "   #'!                  3                                    1                8,&"                          9&H     ?  &  3   "            899 % .>?8B&         89"                6,%66 #'!               >?"                ' =                 899 μ% .>?8B&      8,&"     -  ± ($/   ;&H 9;:±9888=B±9=5μ%-O99&/                      >?             1    >?                                                                  ' >?8B&              >?                     "                                                           3    $      1        #    "   -*'($'S 7 *./            (   @    '        '  8 855:      4      #/          E                          -! '/       ? "β8 - ?"β8/          >#               -(#/       '             ?"β8              ?"β=           ?"β8                                                   S358 3  ?"β=(#  -' &" ?"β=/                G  3   ?"β=                  "! '    )                  ,3895 ' &" ?"β= ' &" 5- 3 β"   /=99μ     =99μ  !2( >                         "! ' ,:                  "3        G                 -#D'/              E          3      ! ' - 3      " !@(/                     ?            #D'  !@(                          " G    )*)           8 ' ,:    "              ! '       ' &" ?"β=           ' &" 5 !2(@                        3   ->>D/   #D'  >>D      !@(       ' &" ?"β= -O99=/           >>D    ! ' ' &" 5  !2(    -  M99&/               #D'             ' &" ?"β=      ' &" 5   !2(             #D'     !@(          -M99&/      -M9996/          ! '    ?"β=                         5   !2(    -  O99,/ Ad5-TGF-β3 Ad5-lacZ Loss of lumen area (%) 34.2 Change in EEL area (%) 32.6 Vessel collagen area (mm2) 1.45 Adventitial collagen area (mm2) 1.42 Change in vessel collagen area (%) 26.1 Change in adventitial collagen 26.9 area (%) ± ± ± ± ± ± 4.9 15.1 0.21 0.19 14.3 15.2 45.3 ± 5.3 -10.9 ± 6.7 0.89 ± 0.12 0.88 ± 0.11 -22.8 ± 6.6 -25.1 ± 6.2 PBS p (ANOVA) 54.9 ± 4.1 < 0.03 -18.2 ± 6.4 < 0.004 1.00 ± 0.10 < 0.03 0.98 ± 0.10

Ngày đăng: 19/11/2022, 11:35

Xem thêm:

TÀI LIỆU CÙNG NGƯỜI DÙNG

TÀI LIỆU LIÊN QUAN