1102 Lung Permeability Induced by Adenovirus Mediated Vascular Endothelial Growth Factor (VEGF) Gene Transfer Is Mediated Via Direct Endothelial Activation by VEGF Molecular Therapy Vol 5, No 5, May 2[.]
,5::B $ "8@*'%μ@*'' $ "8 $ "8 !> $ "8 -?@/ = % -O99&/ ?@ -T989/ ' $ "8 1100 Cytokine Modulation of Endothelial Cell-Surface Coxsackie Adenovirus Receptor (CAR) Expression Theresa Vincent,1,2 Rebecca L Wendland,1 Ralf F Pettersson,2 Ronald G Crystal,1 Philip L Leopold.1 Weill Medical College of Cornell University, New York, NY, United States; 2Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden 3 ' ' -' / " " G ' ' 3 3 -'@/ G *?αD"8β ?*γ' 6: ' " E ' '@ 3 '@ 3 ' β β" ' '@ -899H/ '@ *?α -8,H/ ?*γ -6:H/ D"8β -=5H/ '@ 7 *?α%?*γ -98H/ *?α%D"8β -;H/ ?*γ%D"8β -9BH/ *?α%?*γ%D"8β -96H/ $ ' '@ 3 ' " 3 0 6: *?α ?*γ 1 ' β 9:H β" 3 -899H/ ' " 3 ; : 3 '@ '@ " ' " '@ '@ ' $ 1 # " -*'($'S 7 *./ ( @ ' ' 8 855: 4 = "/ ->8"%>6"/ " & 3 $*'- *"8 *", * /-M6 % / ' ,9 μ !2( # -β" / :9H &9H " " " - ! / " -23/ D G ! ,99H G ,& ->,99/ ' *"8 *", - /-> ,997 =66±9,, =B,±96& &;&±9=& % O99& / * ->,997 B,&±9,&% M 99; / C * *" 8 *", " " E 1102 Lung Permeability Induced by AdenovirusMediated V ascular Endothelial Growth Factor (VEGF) Vascular Gene T ransfer Is Mediated V ia Direct Endothelial Transfer Via Activation by VEGF Robert J Kaner,1 Ronald G Crystal.1 Weill Medical College of Cornell University, New York, NY, United States 3 S357 C 3 ) 3 >?8B& &;2B >8" >=" ' >? -895 / G "" G >?8B& G >?8B& >?" 6,%66 -#'!/ >?8B& "#'! 3 1 8,&" 9&H ? & 3 " 899 % .>?8B& 89" 6,%66 #'! >?" ' = 899 μ% .>?8B& 8,&" - ± ($/ ;&H 9;:±9888=B±9=5μ%-O99&/ >? 1 >? ' >?8B& >? " 3 $ 1 # " -*'($'S 7 *./ ( @ ' ' 8 855: 4 #/ E -! '/ ? "β8 - ?"β8/ ># -(#/ ' ?"β8 ?"β= ?"β8 S358 3 ?"β=(# -' &" ?"β=/ G 3 ?"β= "! ' ) ,3895 ' &" ?"β= ' &" 5- 3 β" /=99μ =99μ !2( > "! ' ,: "3 G -#D'/ E 3 ! ' - 3 " !@(/ ? #D' !@( " G )*) 8 ' ,: " ! ' ' &" ?"β= ' &" 5 !2(@ 3 ->>D/ #D' >>D !@( ' &" ?"β= -O99=/ >>D ! ' ' &" 5 !2( - M99&/ #D' ' &" ?"β= ' &" 5 !2( #D' !@( -M99&/ -M9996/ ! ' ?"β= 5 !2( - O99,/ Ad5-TGF-β3 Ad5-lacZ Loss of lumen area (%) 34.2 Change in EEL area (%) 32.6 Vessel collagen area (mm2) 1.45 Adventitial collagen area (mm2) 1.42 Change in vessel collagen area (%) 26.1 Change in adventitial collagen 26.9 area (%) ± ± ± ± ± ± 4.9 15.1 0.21 0.19 14.3 15.2 45.3 ± 5.3 -10.9 ± 6.7 0.89 ± 0.12 0.88 ± 0.11 -22.8 ± 6.6 -25.1 ± 6.2 PBS p (ANOVA) 54.9 ± 4.1 < 0.03 -18.2 ± 6.4 < 0.004 1.00 ± 0.10 < 0.03 0.98 ± 0.10