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1102 lung permeability induced by adenovirus mediated vascular endothelial growth factor (VEGF) gene transfer is mediated via direct endothelial activation by VEGF

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1102 Lung Permeability Induced by Adenovirus Mediated Vascular Endothelial Growth Factor (VEGF) Gene Transfer Is Mediated Via Direct Endothelial Activation by VEGF Molecular Therapy Vol 5, No 5, May 2[.]

  ,5::B  $ "8@*'%μ@*''               $ "8           $ "8          !>                 $ "8             -?@/ =                    %            -O99&/ ?@                   -T989/ '                                                      $ "8                   1100 Cytokine Modulation of Endothelial Cell-Surface Coxsackie Adenovirus Receptor (CAR) Expression Theresa Vincent,1,2 Rebecca L Wendland,1 Ralf F Pettersson,2 Ronald G Crystal,1 Philip L Leopold.1 Weill Medical College of Cornell University, New York, NY, United States; 2Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden                                             3                            '                                              '    -' /                                                       "                   "              G    '                                       '                      3        3           -'@/     G                                                        *?αD"8β ?*γ' 6:              '             " E  '       '@ 3                   '@                 3       ' β        β"     '                                              '@                      -899H/ '@                  *?α -8,H/ ?*γ -6:H/   D"8β -=5H/              '@    7 *?α%?*γ -98H/ *?α%D"8β -;H/ ?*γ%D"8β -9BH/  *?α%?*γ%D"8β -96H/ $    '      '@ 3                       ' "       3  0  6:           *?α   ?*γ  1      ' β     9:H β"    3          -899H/      ' "      3            ;  :   3                '@                      '@       "                                '    "    '@                                            '@                     '                           $      1        #    "   -*'($'S 7 *./            (   @    '        '  8 855:      4      = "/      ->8"%>6"/   "       &      3 $*'- *"8 *", *   /-M6 %  / '         ,9 μ  !2(               #    -β"   /                                  :9H           &9H         "    "            "           -           !  /     "            -23/ D                       G            !    ,99H               G      ,&   ->,99/                   '            *"8  *",           - /-> ,997 =66±9,, =B,±96&   &;&±9=& %    O99&          /         *               ->,997 B,&±9,&% M 99;   / C         *                       *" 8    *",                                                       "       "             E                                  1102 Lung Permeability Induced by AdenovirusMediated V ascular Endothelial Growth Factor (VEGF) Vascular Gene T ransfer Is Mediated V ia Direct Endothelial Transfer Via Activation by VEGF Robert J Kaner,1 Ronald G Crystal.1 Weill Medical College of Cornell University, New York, NY, United States                                         3                             S357             C                            3                           ) 3    >?8B&    &;2B                    >8" >=" ' >?           -895 /             G        ""                             G                     >?8B&                                  G     >?8B&              >?"                               6,%66        -#'!/                                            >?8B&               "   #'!                  3                                    1                8,&"                          9&H     ?  &  3   "            899 % .>?8B&         89"                6,%66 #'!               >?"                ' =                 899 μ% .>?8B&      8,&"     -  ± ($/   ;&H 9;:±9888=B±9=5μ%-O99&/                      >?             1    >?                                                                  ' >?8B&              >?                     "                                                           3    $      1        #    "   -*'($'S 7 *./            (   @    '        '  8 855:      4      #/          E                          -! '/       ? "β8 - ?"β8/          >#               -(#/       '             ?"β8              ?"β=           ?"β8                                                   S358 3  ?"β=(#  -' &" ?"β=/                G  3   ?"β=                  "! '    )                  ,3895 ' &" ?"β= ' &" 5- 3 β"   /=99μ     =99μ  !2( >                         "! ' ,:                  "3        G                 -#D'/              E          3      ! ' - 3      " !@(/                     ?            #D'  !@(                          " G    )*)           8 ' ,:    "              ! '       ' &" ?"β=           ' &" 5 !2(@                        3   ->>D/   #D'  >>D      !@(       ' &" ?"β= -O99=/           >>D    ! ' ' &" 5  !2(    -  M99&/               #D'             ' &" ?"β=      ' &" 5   !2(             #D'     !@(          -M99&/      -M9996/          ! '    ?"β=                         5   !2(    -  O99,/ Ad5-TGF-β3 Ad5-lacZ Loss of lumen area (%) 34.2 Change in EEL area (%) 32.6 Vessel collagen area (mm2) 1.45 Adventitial collagen area (mm2) 1.42 Change in vessel collagen area (%) 26.1 Change in adventitial collagen 26.9 area (%) ± ± ± ± ± ± 4.9 15.1 0.21 0.19 14.3 15.2 45.3 ± 5.3 -10.9 ± 6.7 0.89 ± 0.12 0.88 ± 0.11 -22.8 ± 6.6 -25.1 ± 6.2 PBS p (ANOVA) 54.9 ± 4.1 < 0.03 -18.2 ± 6.4 < 0.004 1.00 ± 0.10 < 0.03 0.98 ± 0.10

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