822 augmented apoptosis inducing gene therapy for HCC by p53 under control of AFP promoter in combination with a selectively replication competent oncolytic adenovirus and chemotherapeutic agent

822 Augmented Apoptosis Inducing Gene Therapy for HCC by p53 under Control of AFP Promoter in Combination with a Selectively Replication Competent Oncolytic Adenovirus and Chemotherapeutic Agent Molec[.]

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C@>    3       ' &.>?>8       8,        # (           '   ' &.>?>8                           >? @*' 3          -@ "!@/               ->D('/      ' &.>?>8                                       1    >8       ' &.>?>8         1  !@            #       ' &%=.>?>8' &   ' =         '          ' &%=.>?>8             8,        ' &.>?>8 (        "                ' >?>8                           ' >?>8                             822 Augmented Apoptosis-Inducing Gene Therapy for HCC by p53 under Control of AFP Promoter in Combination with a Selectively Replication-Competent Oncolytic Adenovirus and Chemotherapeutic Agent Yasuyuki Yamada,1 Minoru Takahashi,1 Yasushi Sato,1 Junki Fukaura,1 Tsutomu Sato,1 Satoshi Iyama,1 Takatomi Oku,1 Tetsuya Sumiyoshi,1 Tamotsu Sagawa,1 Yoshiro Niitsu.1 4th Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan                    -C/             )      3        &=   C  &= 3  " Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy !"!    -' /  -' /   '?!"                      )           "      -(@)'/                        ' '?! %@   (@)'  >8'8=("$*'    '?!  %    -'?! /        >82"&&A  >82    ,  '     '(              -B   /C               E      C    3   ' '?! %@                    >8'        &="            &=  3                        #     >8' (@)'     >8'"    "   '                  3         '                                                                &= 3  "   '        '?!                        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C 823 Deletion of E1B 19k Improves the Efficacy of a Midkine-Promoter Based Conditionally Replicative Adenovirus for Neuroblastoma Cells Yasuo Adachi,1 Paul N Reynolds,1,2 Koichi Takayama,1 Minghui Wang,1 Liodmila Kaliberova,1 David T Curiel.1,2 Division of Human Gene Therapy, Departments of Medicine, Pathology, and Surgery; 2the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama, United States '                                              (     -*2/                                                                           -' #A>8/  3                      >8                 -#A/    #A    "                    "      #A               *2      #A   " 3   *2     3   #A          '    ' #A>8                                                        1  ' '  >8 >8' >82-  85$ &&$  /              '         >82 85$                   3                           >82 85$      Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy         0        ' #A>8   ' #.>8       >8          #A      #.             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