312 Enhanced Therapeutic Effect of mRTVP 1 Gene Therapy in Combination with Irradiation for Prostate Cancer Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society[.]
VIRAL VECTORS IN IMMUNOTHERAPY I 309 Oncolytically Enhanced Selectively Replicating Adenovirus for Systemic Application William Luckett,1 Yi Gao,1 Michael Karr,1 Jing Gong,1 Marilyn Lemmon,1 Rodney Prell,1 Sylvie Laquerre.1 Virology, Onyx Pharmaceuticals, Richmond, CA, United States )*+F"98& >82&&A -CY*/ ? )*+F"98& E -CY*/ - / 0 " )*+F"98& CY* 8/ % ,/ G -$/ - *?α/ ' -' #™/ 3 &= @2 )*+F"98& )*+F"688 - 3 $ &" ? D *?α 3 *?α" )*+F"98& 3 *?α" 3 $ 3 310 A Novel Oncolytic Adenovirus Encoding an IL-6/ sIL-6R Fusion Protein Jonathan H Axelrod,1 Stefan Rose-John,2 Eithan Galun.1 The Goldyne Savad Gene Therapy Institute, Hadassah Medical Organization, Jerusalem, Israel; 2Institut fur Biochemie, Christian-Albrechts-Universitat zu Kiel, Kiel, Germany " @ " ! D"B >8' >8' ' & =8, D"B D"B D"B α" -D"B@ D"B@/ β" -8=9/ *?"DB C ' CDB D"B% D"B@ -C "D"B/ 3 >8' 3 D"B # 7 C ->8' "/ C , C4C"; ->8'J/ ,5= - L9=/ ' CDB ' DB ' 3 3 - / @ 7' ' CDB' DB ' ,5= = 6 3 ' CDB >8'" = 3 ,5= ' CDB Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy ,5= * ' DB ' >8'" 7 D"B%D"B@ 8=9 >8' ? " D"B ' CDB 3 D"B D"B@ E D"B% D"B@ " C "D"B 31 In V ivo Anti-T umor Activity of Oncolytic 311 Vivo Anti-Tumor umor Tumor Adenoviruses That Express GM-CSF in Xenograft T Models J Andrew Bristol,1 Hong Ji,1 Mervat Mina,1 Mingzhu Zhu,1 Suzanne Forry-Schaudies,1 David Ennist.1 Genetic Therapy, Inc., A Novartis Company, Gaithersburg, MD, United States ) -)' / " " )' 3 " - #"(?/ " ' " " >,?"8 - @ / >8' 3 3 #"(? >= >8' 3 #"(? " #"(? C =2 ) E -,389; ,389: ,3895 / C =2 @ >8'" " # #"(?" 3 " C #"(?" 3 ? " #"(?" 3 )' " ) " 3 #"(? 3 )' 312 Enhanced Therapeutic Effect of mRTVP-1 Gene Therapy in Combination with Irradiation for Prostate Cancer Takefumi Satoh,1 Maria T Vlachaki,2 Xiaohong Zhu,2 Nobuyuki Kusaka,1 Takashi Saika,1 Terry L Timme,1 Guang Yang,1 Vladimir B Mouraviev,1 Jianxiang Wang,1 Bin Teh,2 Brian Butler,2 Timothy C Thompson.1,2,3 Scott Department of Urology; 2Department of Radiology; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States ( +( " 3 " -C(."0/ J - ./ -F@ / @ G &= @ !"8 S103 VIRAL VECTORS IN IMMUNOTHERAPY I 3 3 " -' @ !"8/ F@ ) ' @ !"8 F@ 8,5%( & 3 896 8;:", 2#' ' @ !"8 & 3 89; & 3 89: !?4 @ & 6: E G E )*) ' @ !"8 F@ $'! ?'( ' @ !"8 -& 3 89; & 3 89: !?4/ C2(( ' %#.%β -& 3 89: !?4/ ' @ !"8-&389:!?4/JF@ ' @ !"8 -& 3 89: !?4/ ' %#.%β J F@ -O99998 O99998 / ' ,;; ' @ !"8 J F@ ' % #.%β -8:8 O99998/ ' %#.%β J F@ -856 O99998/ ' @ !"8 -,=B M99=&9/ (*)+() ' @ !"8 ? 1 313 Evaluation of Recombinant Parvovirus H1 Expressing Interleukin-2 and Monocyte Chemotactic Protein in Gene Therapy of an Experimental Pancreatic Cancer Amor Hajri, Severine Wack, Christiane Dinsart, Juan Cornelis, Jean Rommelaere, Marc Aprahamian #.# -# / C8 3 " -*(8/C " C8 - C8/ 3 , - C8"D,/ 8 -C8"#!8/ E C8 C8"D, M8 D, 3 D, C8"D, C8"#!8 C8"D, 3 3 C8 C8"D, 3 C8 % C8 S104 314 The Epstein-Barr Virus (EBV)/Lipoplex-Mediated Transfection of Interleukin (IL)-12 and IL-18 Genes Augments T Helper (TH1) Immune Responses and Therapeutic Anti-Melanoma Effects of Autologous T umor Tumor Vaccine Hidetsugu Asada,1 Tsunao Kishida,1 Etsuko Satoh,1 Hideyo Hirai,1 Jiro Imanishi,1 Osam Mazda.1 Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan >2.% 3 >2." > " 2 ->2./ ! >2*'8 >2*'"8 G " !" 3 -D/"8, D"8: 8 " -?*/"γ D 28B D"8, D"8: >2.% 3 28B -, 3 89& % /- 9/ & 28B >2." D"8, % D"8: -28B%D"8, 28B%D"8: 28B% D"8,JD"8:/ &8,85 ,B '" D *A >D(' D"8, D"8: ?*"γ 28B%D"8, ?*"γ 2 D *A 28B%D"8," 28B%D"8: 28B%D"8,JD"8: " -">2./ >2." ? ?*"γ -A)/ 28B 28B%D"8, ?*" γ " *A " *A E " #8 " >2.% 3 1 # 315 Antibody Induced Activation Has an Important Role to Play in Retroviral T ransduction Transduction Ryan D Guest,1 David E Gilham,1 Natalia Kirillova,1 Joely Irlam,1 Allison O′Neil,1 Robert E Hawkins.1 CRC Dept of Medical Oncology, Paterson Institute of Cancer Research, Manchester, Greater Manchester, United Kingdom " - " / # " 3 % 3 ) " # D. 2 " $=ε "$,: -? 8/ Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy ... 310 A Novel Oncolytic Adenovirus Encoding an IL-6/ sIL-6R Fusion Protein Jonathan H Axelrod ,1 Stefan Rose-John,2 Eithan Galun .1 The Goldyne Savad Gene Therapy Institute, Hadassah... Galun .1 The Goldyne Savad Gene Therapy Institute, Hadassah Medical Organization, Jerusalem, Israel; 2Institut fur Biochemie, Christian-Albrechts-Universitat zu Kiel, Kiel, Germany