312 enhanced therapeutic effect of mRTVP 1 gene therapy in combination with irradiation for prostate cancer

312 Enhanced Therapeutic Effect of mRTVP 1 Gene Therapy in Combination with Irradiation for Prostate Cancer Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society[.]

VIRAL VECTORS IN IMMUNOTHERAPY I 309 Oncolytically Enhanced Selectively Replicating Adenovirus for Systemic Application William Luckett,1 Yi Gao,1 Michael Karr,1 Jing Gong,1 Marilyn Lemmon,1 Rodney Prell,1 Sylvie Laquerre.1 Virology, Onyx Pharmaceuticals, Richmond, CA, United States                        )*+F"98&  >82&&A                    -CY*/                     ?      )*+F"98&  E      -CY*/          -     / 0  "    )*+F"98&            CY*                                                   8/       %  ,/                                                                G     -$/           - *?α/    '       -' #™/   3                                              &=   @2    )*+F"98&   )*+F"688                 -               3  $                   &" ? D    *?α 3    *?α"   )*+F"98&         3                    *?α"    3 $            3                     310 A Novel Oncolytic Adenovirus Encoding an IL-6/ sIL-6R Fusion Protein Jonathan H Axelrod,1 Stefan Rose-John,2 Eithan Galun.1 The Goldyne Savad Gene Therapy Institute, Hadassah Medical Organization, Jerusalem, Israel; 2Institut fur Biochemie, Christian-Albrechts-Universitat zu Kiel, Kiel, Germany         "                  @                                                 "    !        D"B        >8'        >8'         ' & =8,                                          D"B     D"B       D"B α"    -D"B@   D"B@/     β"   -8=9/            *?"DB C              ' CDB     D"B%D"B@     -C "D"B/            3                  >8'   3  D"B    #  7 C ->8' "/            C ,   C4C";    ->8'J/      ,5=         - L9=/       ' CDB ' DB   '           3               3                - /      @ 7'      ' CDB' DB '      ,5=          =  6                                        3      ' CDB            >8'"                           =              3                            ,5=            ' CDB                                     Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy               ,5=   *           ' DB   '                    >8'" 7         D"B%D"B@    8=9                                  >8' ?      "  D"B         ' CDB                          3  D"B  D"B@       E          D"B%D"B@       "                C "D"B                      31 In V ivo Anti-T umor Activity of Oncolytic 311 Vivo Anti-Tumor umor Tumor Adenoviruses That Express GM-CSF in Xenograft T Models J Andrew Bristol,1 Hong Ji,1 Mervat Mina,1 Mingzhu Zhu,1 Suzanne Forry-Schaudies,1 David Ennist.1 Genetic Therapy, Inc., A Novartis Company, Gaithersburg, MD, United States )       -)' /          "               "     )'           3    "      -#"(?/                       "             ' "               "   >,?"8    -     @         /       >8'    3       3  #"(?          >=     >8'                              3           #"(?   "                     #"(?          C =2            )               E          -,389; ,389:   ,3895      /           C =2            @                                  >8'"               "     #     #"(?" 3         "                                            C                            #"(?" 3                  ?    "     #"(?"  3                  )'            "         )         "                3  #"(?             3                         )'             312 Enhanced Therapeutic Effect of mRTVP-1 Gene Therapy in Combination with Irradiation for Prostate Cancer Takefumi Satoh,1 Maria T Vlachaki,2 Xiaohong Zhu,2 Nobuyuki Kusaka,1 Takashi Saika,1 Terry L Timme,1 Guang Yang,1 Vladimir B Mouraviev,1 Jianxiang Wang,1 Bin Teh,2 Brian Butler,2 Timothy C Thompson.1,2,3 Scott Department of Urology; 2Department of Radiology; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States ( +(             "       3  "     -C(."0/ J  -./                      -F@ /   @             G     &=       @ !"8                         S103 VIRAL VECTORS IN IMMUNOTHERAPY I      3                 3                "   -' @ !"8/          F@          )        ' @ !"8 F@                             8,5%(        & 3 896 8;:", 2#'           ' @ !"8                   & 3 89;  & 3 89: !?4 @              & 6:      E    G                            E                             )*) ' @ !"8   F@                      $'!    ?'(    ' @ !"8 -& 3 89;  & 3 89: !?4/                      C2((         ' %#.%β -& 3 89: !?4/    ' @ !"8-&389:!?4/JF@               ' @ !"8 -& 3 89: !?4/     ' %#.%β J F@  -O99998 O99998   / '         ,;;           ' @ !"8 J F@       ' % #.%β -8:8  O99998/ ' %#.%β J F@  -856  O99998/ ' @ !"8 -,=B M99=&9/ (*)+()      ' @ !"8                                               ?                1              313 Evaluation of Recombinant Parvovirus H1 Expressing Interleukin-2 and Monocyte Chemotactic Protein in Gene Therapy of an Experimental Pancreatic Cancer Amor Hajri, Severine Wack, Christiane Dinsart, Juan Cornelis, Jean Rommelaere, Marc Aprahamian         #.# -#      /   C8                                3                "     -*(8/C                                                                         "                C8 - C8/ 3     , - C8"D,/          8 -C8"#!8/                               E    C8                     C8"D,   M8           D,                         3   D,                                                                        C8"D,                       C8"#!8             C8"D,           3                  3                              C8                           C8"D,                          3                    C8     %      C8 S104 314 The Epstein-Barr Virus (EBV)/Lipoplex-Mediated Transfection of Interleukin (IL)-12 and IL-18 Genes Augments T Helper (TH1) Immune Responses and Therapeutic Anti-Melanoma Effects of Autologous T umor Tumor Vaccine Hidetsugu Asada,1 Tsunao Kishida,1 Etsuko Satoh,1 Hideyo Hirai,1 Jiro Imanishi,1 Osam Mazda.1 Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan  >2.% 3                        >2."           > " 2  ->2./ ! >2*'8   >2*'"8       G    "        !"                  3           -D/"8,   D"8:   8          "         -?*/"γ       D             28B                 D"8,   D"8:    >2.% 3 28B              -, 3 89&  % /-  9/       &      28B                 >2."      D"8,  %  D"8:    -28B%D"8, 28B%D"8:   28B% D"8,JD"8:/      &8,85 ,B '"               D   *A       >D('            D"8, D"8:   ?*"γ               28B%D"8,                 ?*"γ  2 D *A           28B%D"8,"         28B%D"8:   28B%D"8,JD"8:            "                            -">2./                                   >2."          ?      ?*"γ      -A)/     28B    28B%D"8,                         ?*" γ    "       *A              "              *A    E "#8       "                         >2.% 3  1               #                                 315 Antibody Induced Activation Has an Important Role to Play in Retroviral T ransduction Transduction Ryan D Guest,1 David E Gilham,1 Natalia Kirillova,1 Joely Irlam,1 Allison O′Neil,1 Robert E Hawkins.1 CRC Dept of Medical Oncology, Paterson Institute of Cancer Research, Manchester, Greater Manchester, United Kingdom "  - " /              #   "   3                                                     % 3    )                 "                     #D.      2     " $=ε   "$,:                         -? 8/ Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy ...       310 A Novel Oncolytic Adenovirus Encoding an IL-6/ sIL-6R Fusion Protein Jonathan H Axelrod ,1 Stefan Rose-John,2 Eithan Galun .1 The Goldyne Savad Gene Therapy Institute, Hadassah... Galun .1 The Goldyne Savad Gene Therapy Institute, Hadassah Medical Organization, Jerusalem, Israel; 2Institut fur Biochemie, Christian-Albrechts-Universitat zu Kiel, Kiel, Germany