354 Adenoviral eNOS Eluting Stents Result in Accelerated Re Endothelialisation and a Reduction in Neointima Formation in an In Vivo Rabbiat Iliac Artery Stent Model events including structural stress[.]
events including structural stress to a cell Indeed, we found with irnmunostainingthat MPS I mice had a marked increase in nuclear levels ofSTAT3 that is phosphorylated at tyrosine 705 and at serine 727 Wepropose that massive lysosomal storage exerts stress upon the cell, which causes activation ofSTAT3, resulting in upregulation of the elastase proteins MMP-12 and cathepsin S The second goal of this study was to determine if gene therapy could prevent disease High dose neonatal gene therapy with a retroviral vector resulted in 1000 Ulml of serum IDUA activity and prevented upregulation of MMP-12 and cathepsin S RNA, and development of aortic disease in MPS I mice However,animals with