long term serial changes in platelet activation indices following sirolimus eluting and bare metal stents implantation in patients with stable coronary artery disease

Accepted Manuscript Long term serial changes in platelet activation indices following sirolimus eluting and bare metal stents implantation in patients with stable coronary artery disease Maria Marketou, George E Kochiadakis, Aikaterini Giaouzaki, Katerini Sfiridaki, Stelios Petousis, Fragiskos Maragoudakis, Konstantinos Roufas, Despoina Vougia, John Logakis, Gregory Chlouverakis, Panos E Vardas PII: S1109-9666(17)30026-X DOI: 10.1016/j.hjc.2017.01.009 Reference: HJC 118 To appear in: Hellenic Journal of Cardiology Please cite this article as: Marketou M, Kochiadakis GE, Giaouzaki A, Sfiridaki K, Petousis S, Maragoudakis F, Roufas K, Vougia D, Logakis J, Chlouverakis G, Vardas PE, Long term serial changes in platelet activation indices following sirolimus eluting and bare metal stents implantation in patients with stable coronary artery disease, Hellenic Journal of Cardiology (2017), doi: 10.1016/j.hjc.2017.01.009 This is a PDF file of an unedited manuscript that has been accepted for publication As a service to our customers we are providing this early version of the manuscript The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain ACCEPTED MANUSCRIPT Long term serial changes in platelet activation indices following sirolimus eluting and bare metal stents implantation in patients with stable coronary artery disease RI PT Maria Marketou,1 George E Kochiadakis, Aikaterini Giaouzaki, Katerini Sfiridaki,2 Stelios Petousis, Fragiskos Maragoudakis, Konstantinos Roufas, Despoina Vougia, John Logakis,1 Gregory Chlouverakis,3 Panos E Vardas : Cardiology Dept, Heraklion University Hospital, Crete, Greece SC : Regional Blood Bank Centre, Venizelion Hospital, Crete, Greece Address for correspondence: Maria Marketou M AN U ;3: Division of Biostatisctics, School of Medicine, University of Crete Cardiology Dept., Heraklion University Hospital TE D P.O Box 1352, 71110, Heraklion, Crete, Greece Tel: +30 2810 392422 Fax: +30 2810 542055 or +30 2810 542111 AC C EP E-mail: maryemarke@yahoo.gr ACCEPTED MANUSCRIPT Abstract Background: Platelet activation is crucial in the development of stent thrombosis following percutaneous coronary intervention (PCI) We carried out a long-term assessment of multiple RI PT factors implicated in the thrombotic process and markers of platelet activation, after implantation of sirolimus-eluting stents (SES) in patients with stable coronary artery disease (CAD), and we compared the results with those after bare-metal stent (BMS) implantation SC Methods: Forty-seven consecutive patients, aged 70% narrowing of the lumen) of one major epicardial coronary artery and stable CAD, underwent M AN U successful elective PCI and were randomly allocated to SES (n=25) or BMS (n=22) Venous blood was obtained 24 hours before, and 24 hours, 48 hours, month, and months after PCI, for the measurement of plasma sP-selectin, von Willebrand Factor (vWF), fibrinogen, d-dimer, sCD40, factorVIII, b-thromboglobulin (b-TG) and platelet factor (PF-4) TE D Results: There were no significant differences between the two groups in the levels of fibrinogen and d-dimers in peripheral blood However, we observed a significant time effect (p