Đang tải... (xem toàn văn)
177 Optimization of Adenoviral Agents for Virotherapy Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene TherapyS60 ���"������������ ����"�� �"��������[.]
" " " " ! 3 >6 )@?= $*' $*' $*' >6 )@? = 175 Adenoviral Delivery of a Secreted Form of Human Liver Carboxylesterase-2 Sensitizes Osteosarcoma to CPT -1 CPT-1 -11 M Adhiambo Witlox,1 Dinja Oosterhoff,2 Victor W van Beusechem,2 Frank A Kruyt,2 Hidde J Haisma,3 Gerard R Schaap,4 Hans Bras,5 David T Curiel,2,6 Paul I J M Wuisman,1 Herbert M Pinedo,2 Winald R Gerritsen.2 Orthopedics, VU University Medical Center, Amsterdam, Netherlands; 2Division of Gene Therapy Departmen of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands; 3Therapeutic Gene Modulation, University Center for Pharmacy, Groningen, Netherlands; 4Orthopedics, Academic Medical Center, Amsterdam, Netherlands; 5Pathology, Academic Medical Center, Amsterdam, Netherlands; 6Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, United States ) -)(/ ' -' / ! " 88 - / (*"=: G 3 ->/ (*"=: 8999" ! "88 G > 3 ! "88 (*"=: ) (*"=: >", - >,/ >, 1 ' " >, )( G ! "88 )( -# "B= #** "C)( ";, () ",/ ' " >, G 3 ! "88 (*"=: &9 ! "88 8999 # " )( G 89 899 ! "88 ' " >, 3 8"89 H "3 ! "88 3 )( " ' " >, ! "88 )( ' " >, ! "88 176 Bicistronic Conditionally Replication Competent Adenoviral V ectors Which Are Selectively L ytic for Vectors Lytic Breast and Ovarian Cancer Cells but Which Are NonToxic for Normal Breast and Ovarian Epithelial Cells Lixin Zhang,1 Hakan Abkulut,1 Albert Deisseroth.1 Sidney Kimmel Cancer Center, San Diego, CA, United States ) D" >8' D" -' D>8'/ "3 3 F+ ! @ B87 669&"668= ,998 S60 D" -' D$/ G 3 3 D3 N -' D$@>(>8'/ >8' @>( D" 3 ' D$@>(>8' #) 3 ' D$@>(>8' 3 3 &? ' D$ 3 3 ' D>8' 3 3 ' D$@>(>8' E ' D$@>(>8' ($ E &" ? -&?/ ' D$ ' D$@>(>8' ($ &? ' D$@@>(>8' 3 ' ' D$@>(>8' 3 3 3 ' D$@>(>8' 3 " 177 Optimization of Adenoviral Agents for Virotherapy Marianne G Rots,1 Gera K Kamps,1 Simone J van Eert,1 Masato Yamamoto,4 Pamela M J McLaughlin,2 Ate G van der Zee,3 Jerome Schaack,5 Erik Falck-Pedersen,6 David T Curiel,4 Hidde J Haisma.1 Therapeutic Gene Modulation, University Center for Pharmacy, Groningen, Netherlands; 2Pathology and Laboratory Medicine, University of Groningen, Groningen, Netherlands; 3Obstetrics and Gyneacology, University Hospital Groningen, Groningen, Netherlands; 4Medicine, Pathology and Surgery and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, United States; 5Microbiology, University of Colorado Health Sciences Center, Denver, CO, United States; Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, United States 8/ ,/ ) 3 -'@/ - / - > ! , @ / 3 - / = -' =/ ' = 2 3 '@ 3 3 3 Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy " " " " ! >@ 3 ->8' !/ 3 >8' 3 # >8" G 178 Adenylyl CyclaseVI Blocks α-Adrenergic Stimulation-Induced Hypertrophy in Cultured Neonatal Rat Cardiomyocytes Hong Zhu, Suzy Fine, Meihua Gao, David A Roth, David M Roth, John Warner, Kirk Hammond Cell & Molecular Biology, Collateral Therapeutics, Inc., San Diego, California, United States; 2Medicine, UC San Diego, Lo Jolla, California, United States 2 7 ) 3 1 1 1 3 " @ 1 3 " 1 3 . -'./ 3 C 7 '. 1 3 " 1" # 7 3 '. 8/ ,/ * 3 '. -' "'./ E ,6 3 ' 3 $*' @ 7 C3 " 3 '. 3 ( '. -899 μ#/ ? -,9 μ#/ ' "'." ( 1 3 '. α" " ? ' "'. α" -&9 μ#/ 1 ) α" 1 '*? @*' G 3 '. " '. 1 '. G 7 '. 179 Development of Gene Therapy V ectors Based on Vectors Chimpanzee Adenoviruses Soumitra Roy,1 Roberto Calcedo del Hoyo,1 Julie Johnston,1 Guangping Gao,1 James M Wilson.1 Institute of Human Gene Therapy, University of Pennsylvania, Philadelphia, PA, United States ' C 1 1 # G - ' & ' ,/ $ E " G Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy !"& !"B !"; B: -!"5/ ,5= ( =B E G G G G 1 G 3 1 !"B @ B:-!"5/ G !"B0 ,5= >8 B:I >8 6 G !"& !"B !"; G 3 ,5= >8 G !"& !"B !"; 3 @' 3 ?! - / I ?! 3 ? ?! @' $*' - / - / @ "> ?! - ?!/ G -# ?! >8" 3 " > ?! #. >8" " >3 G G ( "> ?! " 3 E "> ?! ? #."."> ?! >8" ' & ! 3 8H "" - / S61 ... )@? = 175 Adenoviral Delivery of a Secreted Form of Human Liver Carboxylesterase-2 Sensitizes Osteosarcoma to CPT -1 CPT-1 -11 M Adhiambo Witlox,1 Dinja Oosterhoff,2 Victor W van Beusechem,2... Netherlands; 2Division of Gene Therapy Departmen of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands; 3Therapeutic Gene Modulation, University Center for Pharmacy, Groningen,... Netherlands; 5Pathology, Academic Medical Center, Amsterdam, Netherlands; 6Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, United States ) -)(/