249 CTLA4 Ig and Cyclophosphamide Can Inhibit an Antibody Response to Human Factor × in Balb/C Mice after Retroviral Vector Mediated Gene Therapy Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2[.]
=" " =" " 248 Gene Therapy for Hemophilia A Using Lentiviral Vectors 247 Preclinical T rials of a Helper-Dependent Trials Adenoviral V ector for the T reatment of Murine and Vector Treatment Canine Models of Hemophilia A Neeltje A Kootstra,1 Ryusuke Matsumura,1 Inder M Verma.1 Lab of Genetics, The Salk Institute, La Jolla, CA, United States Brian D Brown,1 Chang Xin Shi,2 Fiona Grant,1 Shawn Tinlin,1 Alexis McKinven,1 Sandra Webster,1 Frank L Graham,2 David P Lillicrap.1 Department of Pathology, Queens University, Kingston, Ontario, Canada; 2Department of Biology, McMaster University, Hamilton, Ontario, Canada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μ% I =9 %I ,9 % * 3 &;%B?. " ) -M89/ 89μ ,6 " -!/ ' -M:/ 1 -2#/ ?. - 899/ 2 G ?. '! D ?. -O& %/ ! E 2#0 G ?. G ?. G G ?. !@ $*' 2# !"E 2#" ?. ?. G 3" 2# C ?. -8:"8=9 % ,6 / ! E 2# ?. ?. ! E C ?. G ?. G ?.% @8 249 CTLA4-Ig and Cyclophosphamide Can Inhibit an Antibody Response to Human Factor X in Balb/C Mice after Retroviral V ector-Mediated Gene Therapy Vector-Mediated Jun Zhang, Frances Wong, Cuihua Gao, Lingfei Xu, Jason Wong, Katherine P Ponder Department of Internal Medicine and Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, United States ' E ? " C D'6" 2; $,: " $*' ? -C ?/ Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy =" " B 2% ' # -#D./" -@./ 3 ? F - ?F/ E -L83895 % / D'6" ! ,& % % , , E @. &9 % % = : 8 ( = ?F" ,B ±&6 % ? " ?F >D(' ? " & & 8 , @. 66,μ% ' -,89μ%/: * & " : E ) & D'6" B μ% 6 6 : ?F ! ?F *" D , " ) 3 " D ?F" D ?F 1 @." ' 3 ?F D * 2% ?F @." D'6" 1 @." 250 High Level Expression of Canine Factor IX in Hemophilia B Dogs after Readminstration of AA V2/5 AAV2/5 Vectors Lili Wang,1 Timothy C Nichols,2 Marjorie S Read,2 Dwight A Bellinger,2 Inder M Verma,3 James M Wilson.1 Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, United States; 3Laboratory of Genetics, The Salk Institute, La Jolla, CA, United States C 2 F" F ' E 2 " 3 ?F 3 3 E " - ''./ F -?F/ $*' " % -D(!/ " 2 ( 3 ?F -&H / E ''., 6B 3 89 8, % 2 -02 / -! / *" F 3 ?F # G C -,:389 88 % / ?F 3 -= % / 2 ''.& ''., ''.,%& ?F ''.,%& ''., @ ''.& ?F ''., Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy ?F 3 -== % BBH / D" 3 ?F 02 ! " 2 ->2./ $*' 3 E $*' 3 F - ?F/ " " &X =X 1 3 >2. >2*'8 ?F 3 89"899" ' -T& %/ ?F : 3 $*' >2. 1 " S83