655 ERK Inhibition Substantially Improves Early Stage Mortality in Acute Pancreatitis The First Report of AAV Vector Mediated Gene Modulation in an Exocrine Pancreatic Disease Molecular Therapy Volume[.]
AAV EXPERIMENTAL THERAPEUTICS was administered intravenously (IV; 1011 genome copies) into mice and anti-cocaine antibody levels quantified by ELISA At 12 wk, the anti-cocaine antibody reciprocal titers were 6.0 x 104 ± 9.6 x 103, with high affinity (determined by radioimmunoassay) for cocaine of 25 nM To assess the ability of AAVrh.10αCoc to shield the brain from administered cocaine, 3H-cocaine was used to trace drug distribution A cocaine challenge that induced high brain levels of cocaine within after administration in naive mice was reduced by 73% in AAVrh.10αCoc treated mice (p