determine of egfr mutation prevalence in advance and metabolic lung
VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol 38, No (2022) 44-49 Original Article Determination of EGFR Mutation Prevalence in Advanced and Metastatic Lung Squamous Cell Carcinoma in Vietnam Mai Trong Khoa1, Nguyen Son Lam2, Pham Cam Phuong1,*, Nguyen Thuan Loi1, Vo Thi Thuy Quynh1, Pham Van Thai1, Pham Van Tuyen1, Vu Binh Thu1, Vu Thi Thu Hien1, Hoang Quoc Bình1, Le Thi Bich Ngoc1 Bach Mai Hospital, 78 Giai Phong, Dong Da, Hanoi, Vietnam Pham Ngoc Thach Hospital, 120 Hong Bang, 5, Ho Chi Minh, Vietnam Received 23 April 2022 Revised 07 June 2022; Accepted 11 June 2022 Abstract: This paper aims to determine the rate of epidermal growth factor receptor (EGFR) gene mutations in advanced and metastatic squamous cell lung cancer in Vietnamese patients EGFR mutation testing was performed on 559 formalin-fixed paraffin-embedded tissue samples from advanced and metastatic squamous cell lung cancer patients by real-time PCR The results showed that EGFR mutations were found in 8.4% Most of them were exon 19 deletions, approximately 51.1% Multivariate analysis showed that EGFR mutations were more prevalent in gender (p