Curriculum Vitae Name: Ling-Ming Tseng, MD Attending Surgeon, Division of General Surgery, Department of Surgery, Veterans General Hospital-Taipei, Associate professor, National Yang-Ming University, Associate professor, National Defense Medical Center Taiwan, Republic of China Education: 1982 08 – 1989.07 National Defense Medical Center M.D Address of affiliated institution: No.201, Sec 2, Shih-Pai Rd.(Shi-Pai Rd.) Taipei (11217), Taiwan, R.O.C Surgical & Research Training: 1992-1996 Surgical Resident in Veterans General Hospital, Taipei 1996-1997 Chief Resident in Surgery in Veterans General Hospital, Taipei, ROC 1998Attending Surgeon Division of General Surgery, Department of Surgery, Veterans General Hospital-Taipei, Taiwan, ROC 2005.12 -2006.11 Visiting Scientist of Department of Surgical Oncology & Department of Molecular& Cellular Oncology, MD Anderson Cancer Center, the University of Texas, USA Current Appointments: 1998Attending Surgeon in Division of General Surgery, Department of Surgery, Veterans General Hospital-Taipei 1998Committeeman of Breast Cancer Committee, Taiwan Cooperative Oncology Group, Division of Cancer Research, National Health Research Institutes 2000-2009 Secretary General of Taiwan association of endocrine surgeons 2007-2010 Council of The Breast Cancer Society of Taiwan 2009Council of Taiwan association of endocrine surgeons 2010Secretary General of The Breast Cancer Society of Taiwan Certification: 1996 Chinese Board of Surgery 1997 Chinese Board of Surgical Gastroenterology 1999 Chinese Board of Surgical Breast 2000 Chinese Board of Surgical endocrinology 2005-2006 Visiting Scientist of Molecular & cellular Oncology, Surgical Oncology, MD Anderson Cancer Center 2012 The Board of Surgical Oncology of the Chinese Oncology Society and Taiwan Surgical Association Membership in Medical and Scientific Society: Taiwan Surgical Association Taiwan Association of Gastrointestinal Surgery Taiwan Association of Endocrine Surgeons The Breast Cancer Society of Taiwan The Chinese Oncology Society Textbook Endocrine Surgery Principles and Practice Hubbard, Johnathan; Inabnet, William B.; Lo, Chung-Yau (Eds.) Springer Specialist Surgery Series Pain Management Yearbook 2013 Joav Merrick, MD, MMedSci, DMSc (Eds.) Pediatrics, Child and Adolescent Health (Pub Date: 2014 - 3rd Quarter) Awards 2014 Excellent paper presentation of breast of Surgery 2013 Excellent paper presentation of breast of Surgery 2013 Outstanding Paper Award of Merck 2013 Excellent MD Physician Award of Taipei Veterans General Hospital 2012 Second Medical Innovation Award of Taipei Veterans General Hospital 2012 Excellent paper presentation of breast of Surgery 2012 Outstanding Paper Award of Merck Publications (*correspondence): Wu YT, Chen ST, Chen CJ, Kuo YL, Tseng LM, Chen DR, Kuo SJ, Lai HW Breast cancer arising within fibroadenoma: collective analysis of case reports in the literature and hints on treatment policy World J Surg Oncol 2014 Nov 10;12(1):335(I F=1.20) Chou HP, Tseng LM Outcome of mammography screening in Taiwan J Chin Med Assoc 2014 Oct;77(10):503-4 Liu CY, Hung MH, Wang DS, Chu PY, Su JC, Teng TH, Huang CT, Chao TT, Wang CY, Shiau CW, Tseng LM*, Chen KF Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A dependent phospho-Akt inactivation in estrogen-receptor negative human breast cancer cells Breast Cancer Res 2014 Sep 17;16(5):431 (I F=5.881；R/C=25/202；Oncology) Liang SY, Wu SF, Chao TC, Tseng LM, Wu WW, Wang TJ, Lu YY The Impact of Pain on the Quality of Life of Taiwanese Oncology Patients Pain Manag Nurs 2014 Sep pii: S15249042(14)00093-9 (I F=1.787) Yeh DC, Chen DR, Chao TY, Chen SC, Wang HC, Rau KM, Feng YH, Chang YC, Lee KD, Ou-Yang F, Kuo WH, Chang KJ, Lin YC, Tseng LM*, Hou MF EORTC QLQ-BM22 Quality of Life Evaluation and Pain Outcome in Patients with Bone Metastases from Breast Cancer Treated with Zoledronic Acid In Vivo 2014 09-10;28(5):1001-1004 (I F=1.148) Noomhorm N, Chang CJ, Wen CS, Wang JY, Chen JL, Tseng LM, Chen WS, Chiu JH, Shyr YM In vitro and in vivo effects of xanthorrhizol on human breast cancer mcf-7 cells treated with tamoxifen J Pharmacol Sci 2014;125(4):375-85 (I F=3.007；R/C=76/254；Pharmacology & Pharmacy) Chiu JH, Chang CJ, Wu JC, Liu HJ, Wen CS, Hsu CH, Chen JL, Tseng LM*, Chen WS, Shyr YM Screening to identify Commonly Used Chinese Herbs that affect ERBB2 and ESR1 Gene Expression using the Human Breast Cancer MCF-7 Cell Line Evidence-Based Complementary and Alternative Medicine Epub 2014 May 27 (I F=1.722 ； R/C=8/22 ； INTEGRATIVE & COMPLEMENTARY MEDICINE) Liu CY, Su JC, Ni MH, Tseng LM, Chu PY, Wang DS, Tai WT, Kao YP, Hung MH, Shiau CW, Chen KF Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells Breast Cancer Res Treat 2014 Jul;146(1):71-84 (I F=5.872；R/C=26/197；ONCOLOGY) Fu CH, Lin RJ, Yu J, Chang WW, Liao GS, Chang WY, Tseng LM, Tsai YF, Yu JC, Yu AL A novel oncogenic role of inositol phosphatase SHIP2 in ER-Negative breast cancer stem cells: Involvement of JNK/Vimentin activation Stem Cells 2014 May doi: 10.1002/stem.1735 Hung MH, Liu CY, Shiau CY, Hsu CY, Tsai YF, Wang YL, Tai LC, King KL, Chao TC, Chiu JH, Su CH, Lo SS, Tzeng CH, Shyr YM, Tseng LM* Effect of Age and Biological Subtype on the Risk and Timing of Brain Metastasis in Breast Cancer Patients PLoS ONE 9(2): e89389 (I F=3.730 ； R/C=7/56；MULTIDISCIPLINARY SCIENCES) 10 11 Chen JL, Chang CJ, Wang JY, Wen CS, Tseng LM, Chang WC, Noomhorm N, Liu HJ, Chen WS, Chiu JH, Shyr YM In Vitro and In Vivo Effects of Jia-Wei-Xiao-Yao-San in Human Breast Cancer MCF-7 Cells Treated With Tamoxifen Integr Cancer Ther 2014 Feb 12;13(3):226-239 (I F=2.354；R/C=4/22 in Integrative & Complementary Medicine | 108/196 in Oncology) 12 Cramarossa G, Zeng L, Zhang L, Tseng LM, Hou MF, Fairchild A, Vassiliou V, Jesus-Garcia R, El-Din MA, Kumar A, Forges F, Chie WC, Sahgal A, Lam H, Pulenzas N, Chow E Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30 Expert Rev Pharmacoecon Outcomes Res 2013 Dec 10 Chao TC, Chen DR, Chao TY, Chen SC, Yeh DC, Wang HC, Huang WT, Rau KM, Chang KJ, Yang TL, Lee KD, Tai CJ, Tseng LM, Hou MF Quality of Life Assessment in Taiwanese Patients with Bone Metastases from Breast Cancer Receiving Zoledronic Acid Anticancer Res 2013 Dec;33(12):55435547 (I F=1.872) Lan YC, Chang CL, Sung MT, Yin PH, Hsu CC, Wang KC, Lee HC, Tseng LM*, Chi CW Zoledronic Acid-induced Cytotoxicity Through Endoplasmic Reticulum Stress Triggered REDD1-mTOR Pathway in Breast Cancer Cells Anticancer Res 2013 Sep;33(9):3807-14 (I F=1.872) 13 14 15 16 Liu CY, Tseng LM, Su JC, Chang KC, Chu PY, Tai WT, Shiau CW, Chen KF Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells Breast Cancer Research 2013 Aug 12;15(4):R63 (I F=5.872；R/C=26/197；ONCOLOGY) Tsai CH, Yang CW, Wang JY, Tsai YF, Tseng LM*, King KL, Chen WS, Chiu JH, Shyr YM Timosaponin AIII Suppresses Hepatocyte Growth Factor-Induced Invasive Activity through Sustained ERK Activation in Breast Cancer MDA-MB-231 Cells Evid Based Complement Alternat Med Epub 2013 Jun 25 17 18 19 20 21 22 23 24 25 26 27 28 Saura C, Tseng LM, Chan S, Chacko RT, Campone M, Manikhas A, Nag SM, Leichman CG, Dasappa L, Fasching PA, Hurtado de Mendoza F, Symmans WF, Liu D, Mukhopadhyay P, Horak C, Xing G, Pusztai L Neoadjuvant Doxorubicin/Cyclophosphamide Followed by Ixabepilone or Paclitaxel in Early Stage Breast Cancer and Evaluation of βIII-Tubulin Expression as a Predictive Marker Oncologist 2013;18(7):787-94 Wong E, Chow E, Zhang L, Bedard G, Lam K, Fairchild A, Vassiliou V, Alm El-Din MA, Jesus-Garcia R, Kumar A, Forges F, Tseng LM, Hou MF, Chie WC, Bottomley A Factors influencing health related quality of life in cancer patients with bone metastases J Palliat Med 2013 Aug;16(8):915-21 Lai HW, Tseng LM, Chang TW, Kuo YL, Hsieh CM, Chen ST, Kuo SJ, Su CC, Chen DR The prognostic significance of metaplastic carcinoma of the breast (MCB) - A case controlled comparison study with infiltrating ductal carcinoma Breast 2013 Jun 17 Lam K, Chow E, Zhang L, Wong E, Bedard G, Fairchild A, Vassiliou V, El-Din MA, Jesus-Garcia R, Kumar A, Forges F, Tseng LM, Hou MF, Chie WC, Bottomley A Determinants of quality of life in advanced cancer patients with bone metastases undergoing palliative radiation treatment Support Care Cancer 2013 Jun 19 Huang SM, Chien LY, Tai CJ, Tseng LM, Chen PH, Tai CJ Increases in Xu Zheng and Yu Zheng among Patients with Breast Cancer Receiving Different Anticancer Drug Therapies Evid Based Complement Alternat Med pub 2013 Mar 21 Lai HW, Wu HK, Kuo SJ, Chen ST, Tseng HS, Tseng LM, Chen DR Differences in accuracy and underestimation rates for 14- versus 16-gauge core needle biopsies in ultrasound-detectable breast lesions Asian J Surg 2013 Apr;36(2):83-8 Lam K, Zeng L, Zhang L, Tseng LM, Hou MF, Fairchild A, Vassiliou V, Jesus-Garcia R, El-Din MA, Kumar A, Pharmd FF, Chie WC, Sahgal A, Poon M, Chow E Predictive Factors of Overall WellBeing Using the EORTC QLQ-C15-PAL Extracted from the EORTC QLQ-C30 J Palliat Med 2013 Mar Tseng LM, Hsu NC, Chen SC, Lu YS, Lin CH, Chang DY, Li H, Lin YC, Chang HK, Chao TC, Ouyang F, Hou MF Distant metastasis in triple-negative breast cancer Neoplasma 2013;60(3):290-4 Horak CE, Pusztai L, Xing G, Trifan OC, Saura C, Tseng LM, Chan S, Welcher R, Liu D Biomarker Analysis of Neoadjuvant Doxorubicin/Cyclophosphamide Followed by Ixabepilone or Paclitaxel in Early-stage Breast Cancer Clin Cancer Res 2013 Jan 22 Chen JL, Wang JY, Tsai YF, Lin YH, Tseng LM*, Chang WC, King KL, Chen WS, Chiu JH, Shyr YM In vivo and in vitro demonstration of herb-drug interference in human breast cancer cells treated with tamoxifen and trastuzumab Menopause 2013 Jan 21 (IF=3.163 ； R/C=10/78 ； OBSTETRICS & GYNECOLOGY) Hsu HY, Lin TY, Hwang PA, Tseng LM, Chen RH, Tsao SM, Hsu J Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFβ receptor degradation in breast cancer Carcinogenesis 2013 Jan 18 Ke CC, Liu RS, Yang AH, Liu CS, Chi CW, Tseng LM, Tsai YF, Ho JH, Lee CH, Lee OK CD133expressing thyroid cancer cells are undifferentiated, radioresistant and survive radioiodide therapy 29 30 31 32 33 34 35 36 37 38 39 40 Eur J Nucl Med Mol Imaging 2013 Jan;40(1):61-71 Lai YC, Hsu CY, Chou YH, Tiu CM, Tseng LM, Wang HK, Chiou HJ Sonographic presentations of metaplastic breast cancers J Chin Med Assoc 2012 Nov;75(11):589-94 Huang SM, Tai CJ, Lin KC, Tai CJ, Tseng LM, Chien LY A Comparative Study of Symptoms and Quality of Life Among Patients With Breast Cancer Receiving Target, Chemotherapy, or Combined Therapy Cancer Nurs 2012 Oct Zeng L, Chow E, Bedard G, Zhang L, Fairchild A, Vassiliou V, Alm El-Din MA, Jesus-Garcia R, Kumar A, Forges F, Tseng LM, Hou MF, Chie WC, Bottomley A Quality of Life After Palliative Radiation Therapy for Patients With Painful Bone Metastases: Results of an International Study Validating the EORTC QLQ-BM22 Int J Radiat Oncol Biol Phys 2012 Jul (IF 4.105) Zeng L, Chow E, Zhang L, Tseng LM, Hou MF, Fairchild A, Vassiliou V, Jesus-Garcia R, El-Din MA, Kumar A, Forges F, Chie WC, Bedard G, Bottomley A An international prospective study establishing minimal clinically important differences in the EORTC QLQ-BM22 and QLQ-C30 in cancer patients with bone metastases Support Care Cancer 2012 May Tseng LM, Liu CY, Chang KC, Chu PY, Shiau CW, Chen KF CIP2A is a target of bortezomib in human triple negative breast cancer cells Breast Cancer Res 2012 Apr 26;14(2):R68 (I F=5.87；R/C= 26/196；ONCOLOGY) Lo WL, Chu PY, Lee TH, Su TL, Chien Y, Chen YW, Huang PI, Tseng LM, Tu PH, Kao SY, Lo JF A Combined DNA-Affinic Molecule and N-Mustard Alkylating Agent Has an Anti-Cancer Effect and Induces Autophagy in Oral Cancer Cells Int J Mol Sci 2012;13(3):3277-90 Lo WL, Chien Y, Chiou GY, Tseng LM, Hsu HS, Chang YL, Lu KH, Chien CS, Wang ML, Chen YW, Huang PI, Hu FW, Yu CC, Chu PY, Chiou SH Nuclear localization signal-enhanced RNA interference of EZH2 and Oct4 in the eradication of head and neck squamous Cell carcinoma-derived cancer stem cells Biomaterials 2012 May;33(14):3693-709 Tseng LM, Huang PI, Chen YR, Chen YC, Chou YC, Chen YW, Chang YL, Hsu HS, Lan YT, Chen KH, Chi CW, Chiou SH, Yang DM, Lee CH Targeting STAT3 Pathway by Cucurbitacin I Diminishes Self-renewaling and Radiochemoresistant Abilities in Thyroid Cancer-derived CD133+ Cells J Pharmacol Exp Ther 2012 May;341(2):410-23 Chiou GY, Cherng JY, Hsu HS, Wang ML, Tsai CM, Lu KH, Chien Y, Hung SC, Chen YW, Wong CI, Tseng LM, Huang PI, Yu CC, Hsu WH, Chiou SH Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma J Control Release 2012 Apr 30;159(2):240-50 Chuang HH, Yang CH, Tsay YG, Hsu CY, Tseng LM, Chang ZF, Lee HH ROCKII serine 1366 phosphorylation reflects the activation status Biochem J 2012 Apr 1;443(1):145-51 Baselga J, Bradbury I, Eidtmann H, Di Cosimo S, de Azambuja E, Aura C, Gómez H, Dinh P, Fauria K, Van Dooren V, Aktan G, Goldhirsch A, Chang TW, Horváth Z, Coccia-Portugal M, Domont J, Tseng LM, Kunz G, Sohn JH, Semiglazov V, Lerzo G, Palacova M, Probachai V, Pusztai L, Untch M, Gelber RD, Piccart-Gebhart M; on behalf of the NeoALTTO Study Team Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase trial.Lancet 2012 Jan 16 ( I F=39.060；R/C= 2/151；MEDICINE, GENERAL & INTERNAL) Gianni L, Pienkowski T, Im YH, Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba5 41 42 43 44 45 46 47 48 49 50 51 52 Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi G, Szado T, Ratnayake J, Ross G, Valagussa P Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase trial Lancet Oncol 2011 Dec Chang CJ, Chien Y, Lu KH, Chang SC, Chou YC, Huang CS, Chang CH, Chen KH, Chang YL, Tseng LM, Song WS, Wang JJ, Lin JK, Huang PI, Lan YT Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells Biochem Biophys Res Commun 2011 Oct 19 Wu CL, Tiu CM, Chen JD, Tseng LM, Chou YH, Chang CY Gauzoma of the Breast Breast J 2011 Sep 23 Yang PS, Yin PH, Tseng LM*, Yang CH, Hsu CY, Lee MY, Horng CF, Chi CW Rab5A is associated with axillary lymph node metastasis in breast cancer patients Cancer Sci 2011 Sep Lai HW, Chien SY, Kuo SJ, Tseng LM, Lin HY, Chi CW, Chen DR The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin Evid Based Complement Alternat Med 2012;2012:486568 Epub 2011 Jun Chow E, Nguyen J, Zhang L, Tseng LM, Hou MF, Fairchild A, Vassiliou V, Jesus-Garcia R, El-Din MA, Kumar A, Forges F, Chie WC, Bottomley A; On behalf of the European Organization for Research Treatment of Cancer Quality of Life Group International field testing of the reliability and validity of the EORTC QLQ-BM22 module to assess health-related quality of life in patients with bone metastases Cancer 2011 Aug 11 Tseng LM, Yin PH, Yang CW, Tsai YF, Hsu CY, Chi CW, Lee HC Somatic mutations of the mitochondrial genome in human breast cancers Genes Chromosomes Cancer 2011 Jul 11( I F=3.546； R/C= 65/196；ONCOLOGY) Lu YS, Chen DR, Tseng LM, Yeh DC, Chen ST, Hsieh CM, Wang HC, Yeh HT, Kuo SH, Huang CS Phase II study of docetaxel, capecitabine, and cisplatin as neoadjuvant chemotherapy for locally advanced breast cancer Cancer Chemother Pharmacol 2011 Jun;67(6):1257-63 Yang YP, Chang YL, Huang PI, Chiou GY, Tseng LM, Chiou SH, Chen MH, Chen MT, Shih YH, Chang CH, Hsu CC, Ma HI, Wang CT, Tsai LL, Yu CC, Chang CJ Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis J Cell Physiol 2011 Apr 18 Zhang S, Huang WC, Li, P., Guo H, Poh, SB, Brady, S W., Xiong, Y., Tseng LM, Li SH, Ding Z, Sahin A, Esteva FJ, Hortobagyi G, Yu D Combating Trastuzumab Resistance by Targeting Src, a Common Node Downstream of Multiple Resistance Pathways Nature Medicine, 2011 Apr;17(4):461-9 ( I F=24.302；R/C=3/290；BIOCHEMISTRY & MOLECULAR BIOLOGY) Lo WL, Yu CC, Chiou GY, Chen YW, Huang PI, Chien CS, Tseng LM, Chu PY, Lu KH, Chang KW, Kao SY, Chiou SH MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells J Pathol 2011 Mar;223(4):482-95 Yu CC, Chen YW, Chiou GY, Tsai LL, Huang PI, Chang CY, Tseng LM, Chiou SH, Yen SH, Chou MY, Chu PY, Lo WL MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation Oral Oncol 2011 Feb Hsu HS, Huang PI, Chang YL, Tzao C, Chen YW, Shih HC, Hung SC, Chen YC, Tseng LM, Chiou SH Cucurbitacin i inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells Cancer 2011 Jan 10 53 Yu CC, Chiou GY, Chen YW, Huang PI, Chien CS, Tseng LM, Chu PY, Lu KH, Chang KW, Kao SY, Chiou SH MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells J Pathol 2010 Nov 23 54 Li HY, Chen YJ, Chen SJ, Kao CL, Tseng LM, Lo WL, Chang CM, Yang DM, Ku HH, Twu NF, Liao CY, Chiou SH, and Chang YL Induction of insulin-producing cells derived from endometrial mesenchymal stem-like cells The Journal of Pharmacology and Experimental Therapeutics, 2010 Dec;335(3):817-29 55 Yu CC, Lo WL, Chen YW, Huang PI, Hsu HS, Tseng LM, Hung SC, Kao SY, Chang CJ, and Chiou SH Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells Journal of Oncology, 2011;2011 56 Chen YW, Chen KH, Huang PI, Chen YC, Chiou GY, Lo WL, Tseng LM, Hsu HS, Chang KW, and Chiou SH Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma derived CD44(+)ALDH1(+) cells Molecular Cancer Therapeutics, 2010 Nov: 9(11):2879-92 57 Chia-Wei Hung, Ying-Jay Liou, Shao-Wei Lu, Ling-Ming Tseng, Chung-Lan Kao, Shih-Jen Chen, Shih-Hwa Chiou and Charn-Jung Chang Stem Cell-Based Neuroprotective and Neurorestorative Strategies Int J Mol Sci 2010, 11, 2039-2055 58 Lu YS, Chen DR, Tseng LM, Yeh DC, Chen ST, Hsieh CM, Wang HC, Yeh HT, Kuo SH, Huang CS Phase II study of docetaxel, capecitabine, and cisplatin as neoadjuvant chemotherapy for locally advanced breast cancer Cancer Chemother Pharmacol.2010 Aug 11 59 Chi-Hsien Peng, Yuh-Lih Chang, Chung-Lan Kao, Ling-Ming Tseng, Chih-Chia Wu , Yu-Chih Chen, Ching-Yao Tsai, Lin-Chung Woung, Jorn-Hon, Liu, Shih-Hwa Chiou and Shih-Jen Chen SirT1— A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells Sensors 2010, 10, 61726194 60 Chen YC, Chang CJ, Hsu HS, Chen YW, Tai LK, Tseng LM, Chiou GY, Chang SC, Kao SY, Chiou SH, Lo WL Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1 Oral Oncol 2010 Mar;46(3):158-65 Epub 2009 Dec 29 61 Chih-Wei Hsu, Pen-Hui Yin, Hsin-Chen Lee, Chin-Wen Chi, Ling-Ming Tseng* Mitochondrial DNA Content as a Potential Marker to Predict Response to Anthracycline in Breast Cancer Patients The Breast Journal, 2010 1–7 62 Chen YC, Chen YW, Hsu HS, Tseng LM, Huang PI, Lu KH, Chen DT, Tai LK, Yung MC, Chang SC, Ku HH, Chiou SH, Lo WL Aldehyde dehydrogenase is a putative marker for cancer stem cells in head and neck squamous cancer Biochem Biophys Res Commun 2009 Jul 31;385(3):307-13 Epub 2009 May 18 63 Hawthorne VS, Huang WC, Neal CL, Tseng LM, Hung MC, Yu D ErbB2-mediated Src and signal transducer and activator of transcription activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells Mol Cancer Res 2009 Apr;7(4):592-600 64 Jing Lu, Ming Tan, Wen-Chien Huang, Ping Li, Hua Guo, Ling-Ming Tseng, Xiao-Hua Su, Wen-Tao Yang, Warapen Treekitkarnmongkol, Michael Andreeff, Fraser Symmans, Dihua Yu Mitotic Deregulation by surviving in ErbB2-overexpressiong Breast Cancer cells contributes to Taxol Resistance Clin Cancer Res 2009 Feb 15(4) 1327-34 65 Ling-Ming Tseng, Pen-Hui Yin, Yi-Fang Tsai, Chin-Wen Chi, Chew-Wun Wu, Liang-Ming Lee, Hsinchen Lee Association between mitochondrial DNA 4,977 bp deletion and HAD(p)H: quinine oxidoreductase 1C609T polymorphism in human breast tissues Oncology Report 2009 21:1169-74 66 Wen-Yi Hung, Jin-Ching Lin, Liang-Ming Lee, Chew-Wun Wu, Ling-Ming Tseng, Pen-Hui Yin, ChinWen Chi, and Hsin-Chen Lee Tandem Duplication/Triplication Correlated with Poly-cytosine Stretch Variation in Human Mitochondrial DNA D-loop Region Mutagenesis 2008 Feb,23(2):137-42 67 Wen-Liang Fang, Ling-Ming Tseng, Jui-Yu Chen, See-Ying Chiou, Yi-Hong Chou, Chew-Wun Wu, Chen-Hsen Lee The Management of High Risk Patients with Primary Hyperparathyroidism — Minimally Invasive Parathyroidectomy Versus Medical Treatment Clinical Endocrinology 2008 ,68(4) 520-8 68 Lu CH, Wyszomierski SL, Tseng LM, Sun MH, Lan KU, Neal CL, Mills GB, Hortobagyi GN, Esteva FJ, Yu D Preclinical Testing of Clinically Applicable Strategies for Overcoming Trastuzumab Resistance Caused by PTEN Deficiency Clin Cancer Res 2007 Oct 1;13 (19):5883-8 69 Ling-Min Tseng , Jui-Yu Chen , Justin Ging-Shing Won, Hsiao-Shan Tseng, An-Han Yang, Sine-E Wang, Chen-Hsen Lee The Role of Intra-arterial Calcium Stimulation Test with Hepatic Venous Sampling(IACS) in the Management of Occult Insulinomas Ann Surg Onco 2007 Jul;14(7):2121-7 70 Chang, C J., Chiu, J H., Tseng, L M., Chang C.H Chien, T M., Chen, C C., Wu, C W., and Lui, W Y Si-Wu-Tang and its constituents promote mammary duct cell proliferation by up-regulation of HER-2 signaling Menopause, 13: 967-976, 2006 71 Chang, C J., Chiu, J H Tseng, L M, Chang, C.H., Chien, T.M., Wu, C.W., and Lui, W Y Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells Eur J Clin Invest, 36: 588-596, 2006 72 Chiou, S Y., Chou, Y H., Chiou, H J., Wang, H K., Tiu, C M., Tseng, L M., and Chang, C Y Sonographic features of nonpalpable breast cancer: a study based on ultrasound-guided wire-localized surgical biopsies Ultrasound Med Biol, 32: 1299-1306, 2006 78 Kung, S P., Lee, C H., Yang, A H., Chi, C W., Tseng, L M., and Wu, C W Expression of c-kit, Flk-1, and Flk-2 receptors in benign and malignant tumors of follicular epithelial origin J Chin Med Assoc, 69: 74-79, 2006 79 Lai, H W., Lee, C H., Chen, J Y., Tseng, L M., and Yang, A H Insular thyroid carcinoma: collective analysis of clinicohistologic prognostic factors and treatment effect with radioiodine or radiation therapy J Am Coll Surg,203:715-722, 2006 80 Lee, C H., Tseng, L M., Chen, J Y., Hsiao, H Y., and Yang, A H Primary hyperparathyroidism in multiple endocrine neoplasia type 1: individualized management with low recurrence rates Ann Surg Oncol, 13: 103-109, 2006 81 Liu, J M., Wu, H W., Tiu, C M., Tseng, L M., Yen, S H., Shiau, C Y., Lan, C., and Li, A F Comprehensive Breast Cancer Adjuvant Digital Summary J Digit Imaging,2006 19(3):264-9 82 Tiu, C M., Chou, Y H., Chiou, S Y., Hsu, C Y., Chen, S P., Chiang, H R., Lai, C R., Tseng, L M., Wang, H K., and Chiou, H J Development of a carcinoma in situ in a fibroadenoma: color Doppler sonographic demonstration J Ultrasound Med, 25: 1335-1338, 2006 83 Tseng, L M., Yin, P H., Chi, C W., Hsu, C Y., Wu, C W., Lee, L M., Wei, Y H., and Lee, H C Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer Genes Chromosomes Cancer, 45: 629-638, 2006 84 Yang, A H., Hsu, C W., Chen, J Y., Tseng, L M., Won, G S., and Lee, C H Normocalcemic primary hyperparathyroidism in patients with recurrent kidney stones: pathological analysis of parathyroid glands Virchows Arch, 449: 62-68, 2006 85 Tung,W.H.,Chou Y.H.,Tiu C.M.,Chen S.P.,Chiang H.R.,Tseng L.M.,Chiou H.J.,Chiou S.Y.,Wang H.K.,Yen C.H Demonstration of Ductal Carcinoma in Situ with Microcalcification in a Patient with Augmentation Mammoplasty by Free Silicone Injection J Med Ultrasound,2005, 13:135-139 86 Ta-Chung Chao, Zyting Chu, Ling-Ming Tseng, Tzeon-Jye Chiou, Ruey-Kuen Hsieh, Wei-Shu Wang, Chueh-Chuan Yen, Muh-Hwa Yang, Jin-Hwang Liu, Po-Min Chen Paclitaxel in a noval formulation containing less Cremophor EL as first-line therapy for advanced breast cancer: A phase II trial Investigational New Drugs 23: 171-177, 2005 87 Lee S.M , Tseng LM , Lee A.-F., Liu H.-C., Liu T.-Y., Chi C.-W Polymorphism of estrogen metabolism genes and cataract Medical hypotheses 2004;63 494-97 88 Tseng LM, Hsu CY, Wang HC, Liu JM, Chang HM, Lo SS, Wu CW, Lui WY, Chi CW Tie-1 tyrosine kinase is an independent prognostic indicator for invasive breast cancer Anticancer Res 2001 May-Jun;21(3C):2163-70