P1: SFK/UKS BLBS102-c42 P2: SFK BLBS102-Simpson 816 March 21, 2012 14:27 Trim: 276mm X 219mm Printer Name: Yet to Come Part 8: Food Safety and Food Allegens Gomez JC et al 2001 Prevalence of celiac disease in Argentina: screening of an adult population in the La Plata area Am J Gastroenterol 96(9): 2700–2704 Gonzalez de la Pena MA et al 1991 Isolation and characterization of a major allergen from oriental mustard seeds, Brajl Int Arch Allergy Appl Immunol 96: 263–270 Gonzalez de la Pena MA et al 1996 Expression in Escherichia coli of Sin a 1, the major allergen from mustard Eur J Biochem 237: 827–832 Gonzalez R et al 1992 Purification and characterization of major inhalant allergens from soybean hulls Clin Exp Allergy 22(8): 748–755 Gonzalez R et al 1995 Soybean hydrophobic protein and soybean hull allergy Lancet 346(8966): 48–49 Grundy JR et al 2002 Rising prevalence of allergy to peanut in children: data from sequential cohorts J Allergy Clin Immunol 110(5): 784–778 Hansen KS et al 2003 Roasted hazelnuts – allergenic activity evaluated by double-blind, placebo-controlled food challenge Allergy 58: 132–138 Harish Babu BN et al 2008 A cross-sectional study on the prevalence of food allergy to eggplant (Solanum melongena L.) reveals female predominance Clin Exp Allergy 38(11): 1795– 1802 Hefle SL et al 1996 Allergenic foods Crit Rev Food Sci Nutr 36: S69–S89 Hefle SL et al 2005 Soy sauce retains allergenicity through the fermentation production process J Allergy Clin Immunol 115(2, Suppl): S32 Hefle SL et al 2007 Consumer attitudes and risks associated with packaged foods having advisory labelling regarding the presence of peanuts J Allergy Clin Immunol 120: 171–176 Heine RG et al 2006 The diagnosis and management of egg allergy Curr Allergy Asthma Reports 6: 145–152 Herman EM et al 2003 Genetic modification removes an immunodominant allergen from soybean Plant Physiol 132: 36–43 Hill DJ et al 1999 The natural history of intolerance to soy and extensively hydrolyzed formula in infants with multiple food protein intolerance (MFPI) J Pediatr 135: 118–121 Hischenhuber C et al 2006 Review article: safe amounts of gluten for patients with wheat allergy or coeliac disease Aliment Pharmacol Ther 23(5): 559–575 Holzhauser T et al 2002 Detection of potentially allergenic hazelnut (Corylus avellana) residues in food: a comparative study with DNA PCR-ELISA and protein sandwich-ELISA J Agric Food Chem 50: 5808–5215 Holzhauser T et al 2006 Polymerase chain reaction (PCR) methods for the detection of allergenic foods In: SJ Koppelman, SL Hefle (eds.) Detecting Allergens in Food Woodhead Publishing, Cambridge, pp 125–143 Hori G et al 2001 Soy protein hydrolyzate with bound phospholipids reduces serum cholesterol levels in hypercholesterolemic adult male volunteers Biosci Biotechnol Biochem 65(1): 72–78 Host A, Halken S 1990 A prospective study of cow milk allergy in Danish infants during the first years of life: clinical course in relation to clinical and immunological type of hypersensitivity reaction Allergy 45(8): 587–596 Host A, Samuelsson EG 1988 Allergic reactions to raw, pasteurized, and homogenized/pasteurized cow milk: a comparison A double-blind placebo-controlled study in milk allergic children Allergy 43: 113–118 Hourihane JO et al 1997 An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: a randomized, double-blind, placebo-controlled food challenge study J Allergy Clin Immunol 100: 596–600 Inoue R et al 2001 Identification of beta-lactoglobulin-derived peptides and class II HLA molecules recognized by T cells from patients with milk allergy Clin Exp Allergy 31: 1126–1134 Janatuinen EK et al 1995 A comparison of diets with and without oats in adults with celiac disease N Engl J Med 333(16): 1033–1037 Janatuinen EK et al 2000 Lack of cellular and humoral immunological responses to oats in adults with coeliac disease Gut 46(3): 327–331 Janatuinen EK et al 2002 No harm from five year ingestion of oats in coeliac disease Gut 50(3): 332–335 Jappe U, Vieths S 2010 Lupine, a source of new as well as hidden food allergens Mol Nutr Food Res 54(1): 113–126 Jarvinen KM et al 2001 IgE and IgG binding epitopes on alphalactalbumin and beta-lactoglobulin in cow’s milk allergy Int Arch Allergy Immunol 126: 111–118 Joint FAO/WHO Food Standards Programme and Codex Alimentarius Commission 2008 Report of the 30th Session of the Codex Committee on Nutrition and Foods for Special Dietary Uses, 30 June – July 2008, Geneva, Switzerland ALINORM 08/31/26 Available at http://www codexalimentarius.net/download/report/687/al08_26e.pdf Accessed on 28 November 2011 Jones SM et al 2009 Clinical efficacy and immune regulation with peanut oral immunotherapy J Allergy Clin Immunol 124(2): 292–300 Kahlenberg F et al 2006 Monoclonal antibody R5 for detection of putatively coeliac-toxic gliadin peptides Eur Food Res Technol 222(1–2): 78–82 Kalogeromitros D et al 1996 Anaphylaxis induced by lentils Ann Allergy Asthma Immunol 77(6): 480–482 Kaminogawa S, Totsuka M 2003 Allergenicity of milk proteins In: PF Fox (ed.) Advanced Dairy Chemistry, Volume 1, Proteins Elsevier Science Publications, London, pp 648–674 Kanny G et al 2001 Population study of food allergy in France J Allergy Clin Immunol 108: 133–140 Karjalainen J et al 1992 A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus N Engl J Med 327: 302–307 Keck-Gassenmeier B et al 1999 Determination of peanut traces in food by a commercially available ELISA test Food Agric Immunol 11: 243–250 Kleber N et al 2004 The antigenic response of β-lg is modulated by thermally induced aggregation Eur Food Res Technol 219(2): 105–110 Kleber N et al 2007 Antigenic response of bovine beta lactoglobulin influenced by ultra high pressure treatment and temperature Innovative Food Sci Emerg Technol 8(1): 39–45 Koppelman SJ et al 1999 Heat induced conformational changes of Ara h 1, a major peanut allergen, not affect its allergenic properties J Biol Chem 274(8): 4770–4777 Krishnan HB 2000 Biochemistry and molecular biology of soybean seed storage protein J New Seeds 2(3): 1–25 P1: SFK/UKS BLBS102-c42 P2: SFK BLBS102-Simpson March 21, 2012 14:27 Trim: 276mm X 219mm Printer Name: Yet to Come 42 Food Allergens Krishnan HB et al 2009 All three subunits of soybean βconglycinin are potential food allergens J Agric Food Chem 57(3): 938–943 Kumar R et al 2007 Rice (Oryza sativa) allergy in rhinitis and asthma patients: a clinico-immunological study Immunobiology 212(2): 141–147 L’Hocine L, Boye JI 2007 Allergenicity of soybean: new developments in identification of allergenic proteins, cross-reactivities and hypoallergenization technologies Crit Rev Food Sci Nutr 47(2): 127–143 Laoprasert N et al 1998 Anaphylaxis in a milk-allergic child following ingestion of lemon sorbet containing trace quantities of milk J Food Prot 61: 1522–1524 Leadbeater L, Ward FB 1987 Analysis of tryptic digests of bovine β-casein by reversed-phase high-performance liquid chromatography J Chromatogr 397: 435–443 Leduc V et al 2006 Identification of oleosins as major allergens in sesame seed allergic patients Allergy 61: 349–356 Lee JW et al 2001 Effects of gamma-radiation on the allergenic and antigenic properties of milk proteins J Food Prot 64: 272– 276 Lee PW et al 2008 Sandwich enzyme-linked immunosorbent assay (ELISA) for detection of mustard in foods J Food Sci 73: T62–T68 Lehrer SB et al 2003 Seafood allergy and allergen: a review Mar Biotechnol 5: 339–348 Liu K 1997 Soybeans: Chemistry, Technology and Utilization Chapman and Hall, New York, pp 28–35 Lohi S 2010 Prevalence and prognosis of coeliac disease: a special focus on undetected condition Ph.D Dissertation, Submitted to Faculty of Medicine of the University of Tampere, Finland Lu Y et al 2007 Immunological characteristics of monoclonal antibodies against shellfish major allergen tropomyosin Food Chem 100: 1093–1099 Lundin KE et al 2003 Oats induced villous atrophy in coeliac disease Gut 52(11): 1649–1652 Maleki SJ et al 2000 The effects of roasting on the allergenic properties of peanut proteins J Allergy Clin Immunol 106: 763–768 Martin D, Chapman M 2001 Prediction of the allergenicity of a molecule J Allergy Clin Immunol 41: 13–16 Martorell Aragon´es A et al 2001 Allergy to egg proteins Allergol Immunopathol 29: 84–95 Matricardi PM et al 2003 Microbial products in allergy prevention and therapy Allergy 58: 461–471 Mazzeo MF et al 2003 Identification of transglutaminasemediated deamidation sites in a recombinant alpha-gliadin by advanced mass-spectrometric methodologies Protein Sci 12(11): 2434–2442 Mine Y, Rupa P 2003 Fine mapping and structural analysis of immunodominant IgE allergenic epitopes in chicken egg ovalbumin Prot Eng 16: 747–752 Mine Y, Rupa P 2004 Immunological and biochemical properties of egg allergens World Poult Sci J 60: 321–330 Mine Y, Yang M 2008 Recent advances in the understanding of egg allergens: basic, industrial, and clinical perspectives J Agric Food Chem 56: 4874–4900 Mine Y, Zhang JW 2002 Identification and fine mapping of IgG and IgE epitopes in ovomucoid Biochem Biophys Res Commun 292: 1070–1074 817 Monaci L et al 2006 Milk allergens, their characteristics and their detection in food Eur Food Res Technol 223: 149–179 Moneret-Vautrin A 2006 Allergenic foods: mustard Available at http://www.anaphylaxis.eu/uk_mustard.html Monreal P et al 1992 Two anaphylactic reactions to ingestion of mustard sauce Ann Allergy 69: 317–320 More D 2009 Sesame seed allergy Available at http://allergies about.com/od/otherfoodallergies/a/sesameallergy.htm Accessed on November 28, 2011 Moreno-Bondi MC et al 2003 Multi-analyte analysis system using an antibody-based biochip Anal Bioanal Chem 375: 120–124 Morisset M et al 2003a Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind placebo controlled oral challenges Clin Exp Allergy 33: 1046–1051 Morisset M et al 2003b Prospective study of mustard allergy: first study with double-blind placebo-controlled food challenge trials (24 cases) Allergy 58(4): 295–299 Motala C, Lockey R 2004 Food Allergy World Allergy Organization Allergic Diseases Resource Centre Available at http:// www.worldallergy.org/professional/allergic_diseases_center/ foodallergy/ Munoz-Furlong A et al 2004 Prevalence of self-reported seafood allergy in the U.S J Allergy Clin Immunol 113: S100 Mustorp D et al 2008 Detection of celery (Apium graveolens), mustard (Sinapis alba, Brassica juncea, Brassica nigra) and sesame (Sesanum indicum) in food by real time PCR Eur Food Res Technol 226: 771–778 Nakajima-Adachi H et al 1998 Determinant analysis of IgE and IgG antibodies and T cells specific for bovine alpha s1-casein from the same patients allergic to cow’s milk: existence of alpha s1-casein-specific B cells and T cells characteristic in cow’s milk allergy J Allergy Clin Immunol 101: 660–671 Nakano T et al 2010 Sensitization to casein and β-lactoglobulin (blg) in children with cow’s milk allergy (CMA) Arerugi 59: 117–122 Nentwich I et al 2001 Cow’s milk-specific cellular and humoral immune responses and atopy skin symptoms in infants from atopic families fed a partially (pHF) or extensively (eHF) hydrolyzed infant formula Allergy 56: 1144–1156 Ng-Kwai-Hang KF 2002 Heterogeneity, fractionation and isolation In: H Roginski et al (eds.) Encyclopaedia of Dairy Sciences Academic Press, London, pp 1881–1894 Niemann L et al 2009 Detection of walnut residues in foods using an enzyme-linked immunosorbent assay J Food Sci 74: T51–T57 Nordlee JA, Taylor SL 1995 Immunological analysis of food allergens and other food proteins Food Technol 2: 129–132 Nowak-Wegrzyn A et al 2004 Contamination of dry powder inhalers for asthma with milk proteins containing lactose J Allergy Clin Immunol 113: 558–560 O’Neil C et al 1993 Allergic reactions to fish Clin Rev Allergy 11: 183–200 Ogawa T et al 1991 Investigation of the IgE binding proteins in soybeans by immunoblotting with the sera of the soybeansensitive patients with atopic dermatitis J Nutr Sci Vitaminol 37(6): 555–565 Ogawa T et al 1993 Identification of the soybean allergenic protein, Gly m Bd 30K, with the soybean seed 34-kDa oil-body-associated protein Biosci Biotechnol Biochem 57(6): 1030–1033 P1: SFK/UKS BLBS102-c42 P2: SFK BLBS102-Simpson 818 March 21, 2012 14:27 Trim: 276mm X 219mm Printer Name: Yet to Come Part 8: Food Safety and Food Allegens Oliver S, Vieths S 2004 Development of a real-time PCR and a sandwich ELISA for detection of potentially allergenic trace amounts of peanut (Arachis hypogaea) in processed foods J Agric Food Chem 52: 3754–3760 Oliver S et al 2002 Development and validation of two dipstick type immunoassays for determination of trace amounts of peanut and hazelnut in processed foods Eur Food Res Technol 215: 431–436 Osman AA et al 2001 A monoclonal antibody that recognizes a potential coeliac-toxic repetitive pentapeptide epitope in gliadins Eur J Gastroenterol Hepatol 13(10): 1189–1193 Panconesi E et al 1980 Anaphylactic shock from mustard after ingestion of pizza Contact Dermatitis 6: 294–295 Pastorello EA et al 2001 The major allergen of sesame seeds (Sesamum indicum) is a 2S albumin J Chromatogr B Biomed Sci Appl 756: 85–93 Pedersen HS, Djurtoft R 1989 Antigenic and allergenic properties of acidic and basic peptide chains from glycinin Food Agric Immunol 1(2): 101–109 Pereira MJ et al 2002 The allergenic significance of legumes Allergol Immunopathol 30(6): 346–353 Perkins MS 2000 Sesame allergy Available at www.allergyuk org/fs_sesame.aspx Accessed on February 24, 2010 Pieretti MM et al 2009 Audit of manufactured products: use of allergen advisory labels and identification of labeling ambiguities J Allergy Clin Immunol 124: 337–341 Poms RE et al 2001 Increased sensitivity for detection of specific target DNA in milk by concentration in milk fat Eur Food Res Technol 213: 361–365 Poms RE et al 2004 Methods for allergen analysis in food: a review Food Addit Contam 21: 1–31 Pons L et al 2002 The 18 kDa peanut oleosin is a candidate allergen for IgE-mediated reactions to peanuts Allergy 57(72): 88– 93 Porcel S et al 2006 Food-dependent exercise-induced anaphylaxis to pistachio J Investig Allergol Clin Immunol 16(1): 71– 73 Prioult G et al 2004 Stimulation of interleukin-10 production by acidic beta-lactoglobulin-derived peptides hydrolyzed with Lactobacillus paracasei NCC2461 peptidases Clin Diagn Lab Immunol 11: 266–271 Rajamohamed SH, Boye JI 2010 Processing foods without peanuts and tree nuts In: JI Boye, S Godefroy (eds.) Allergen Management in the Food Industry, Chapter 11 John Wiley & Sons, New York Rance F et al 2000 Mustard allergy in children Allergy 55(5): 496–500 Restani P et al 2004 Characterization of bovine serum albumin epitopes and their role in allergic reactions Allergy 59: 21–24 Romano A et al 2001 Food-dependent exercise-induced anaphylaxis: clinical and laboratory findings in 54 subjects Int Arch Allergy Immunol 125(3): 264–272 Rong-Hwa S et al 2010 Gold nanoparticle-based lateral flow assay for detection of staphylococcal enterotoxin B Food Chem 118: 462–466 Rostami K et al 1999 High prevalence of celiac disease in apparently healthy blood donors suggests a high prevalence of undiagnosed celiac disease in the Dutch population Scand J Gastroenterol 34(3): 276–279 Rozenfeld P et al 2002 Detection and identification of a soy bean component that cross reacts with caseins from cow’s milk Clin Exp Immunol 130: 49–58 Sampson HA 2002 Peanut allergy N Engl J Med 346(17): 1294–1299 Sampson HA 2004 Update on food allergy J Allergy Clin Immunol 113: 805–819 Sampson HA, McCaskill CC 1985 Food hypersensitivity and atopic dermatitis: evaluation of 113 patients J Pediatr 107: 669–675 Sampson HA et al 1992 Fatal and near-fatal anaphylactic reactions to food in children and adolescents N Engl J Med 327(6): 380–384 Scheibe B et al 2001 Detection of trace amounts of hidden allergens: hazelnut and almond proteins in chocolate J Chromatogr B Biomed Sci Appl 756: 229–237 Schubert-Ullrich P et al 2009 Commercialized rapid immunoanalytical tests for determination of allergenic food proteins: an overview Anal Bioanal Chem 395: 69–81 Shefcheck KJ, Musser SJ 2004 Conformation of the allergenic protein Ara h in a model matrix using liquid chromatography/tandem mass spectrometry J Agric Food Chem 52: 2785–2790 Shriver-Lake LC et al 2004 Applications of array biosensor for detection of food allergens J AOAC Int 87: 1498–1502 Sicherer SH 2010 Food allergies eMedicine Available at http://emedicine.medscape.com/article/135959-overview Sicherer SH, Sampson HA 2006 Food allergy J Allergy Clin Immunol 117(2 Suppl Mini-Primer): S470–S475 Sicherer SH, Sampson HA 2010 Food allergy J Allergy Clin Immunol 125: S116–S125 Sicherer SH et al 2001 A voluntary registry for peanut and tree-nut allergy: characteristics of the first 5149 registrants J Allergy Clin Immunol 108: 128–132 Sicherer SH et al 2003 Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study J Allergy Clin Immunol 112(6): 1203–1207 Sicherer SH et al 2004 Prevalence of seafood allergy in the United States determined by a random telephone survey J Allergy Clin Immunol 114: 159–165 Skypala I 2009 Fruits and vegetables In: I Skypala, C Venter (eds.) Food Hypersensitivity: Diagnosing and Managing Food Allergies and Intolerance Blackwell Publishing, Oxford, pp 147–165 Soler-Rivas C, Wichers HJ 2001 Impact of (bio)chemical and physical procedures on food allergen stability Allergy 56(67): 52–55 Spuergin P et al 1996 Allergenic epitopes of bovine alpha s1-casein recognized by human IgE and IgG Allergy 51: 306–312 Staden U et al 2007 Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction Allergy 62: 1261–1269 Stephenson TJ et al 2005 Effect of soy protein-rich diet on renal function in young adults with insulin-dependant diabetes mellitus Clin Nephrol 64(1): 1–11 Stewart GA, Thompson PJ 1996 The biochemistry of common aeroallergens Clin Exp Allergy 26: 1020–1044 Stoppler MC, Marks JW 2005 Sesame seed allergy: a growing problem? Available at www.medicinenet.com/script/ main/art.asp Accessed on February 24, 2010 P1: SFK/UKS BLBS102-c42 P2: SFK BLBS102-Simpson March 21, 2012 14:27 Trim: 276mm X 219mm Printer Name: Yet to Come 42 Food Allergens Taylor SL 2000 Emerging problems with food allergens Food Nutr Agric 26: 14–29 Taylor SL, Hefle SL 2001 Food allergies and other food sensitivities – an application of the Institute of Food Techologists’ expert panel on food safety and nutrition Food Technol 55(9): 68– 83 Taylor SL, Lehrer SB 1996 Principles and characteristics of food allergens Crit Rev Food Sci Nutr 36: S91–S118 Taylor SL et al 2002 Factors affecting the determination of threshold doses for allergenic foods: how much is too much? J Allergy Clin Immunol 109(1): 24–30 Taylor SL et al 2004 Consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much? Clin Exp Allergy 34: 689–695 Taylor SL et al 2009 Allergen immunoassays – considerations for use of naturally incurred standards Anal Bioanal Chem 395: 83–92 Thompson T 2004 Gluten contamination of commercial oat products in the United States N Engl J Med 351(19): 2021– 2022 Thompson T 2005 Contaminated oats and other gluten-free foods in the United States J Am Diet Assoc 105(3): 348–349 Tome D et al 2004 Nutritional value of milk and meat products derived from cloning Cloning Stem Cells 6: 172–177 Towell R 2009 Peanuts, legumes, seeds and tree nuts In: I Skypala, C Venter (eds.) Food Hypersensitivity: Diagnosing and Managing Food Allergies and Intolerance Blackwell Publishing, Oxford, pp 166–182 Valenta R et al 1999 The recombinant allergen-based concept of component resolved diagnostics and immunotherapy (CRD and CRIT) Clin Exp Allergy 29: 896–904 Wal JM 1998 Cow’s milk allergens Allergy 53: 1013–1022 Wal JM 2004 Bovine milk allergenicity Ann Allergy Asthma Immunol 93: 2–11 Walker-Smith J 2003 Hypoallergenic formulas: are they really hypoallergenic? Ann Allergy Asthma Immunol 90: 112–114 819 Walsh BJ et al 1988 New allergens from hen’s egg white and egg yolk: in vitro study of ovomucin, apovitellenin I and VI, and phosvitin Int Arch Allergy Appl Immunol 87: 81–86 Walsh BJ et al 2005 Detection of four distinct groups of hen egg allergens binding IgE in the sera of children with egg allergy Allergol Immunopathol 33: 183–191 Ward PP et al 2002 Lactoferrin and host defense Biochem Cell Biol 80: 95–102 Wen HW et al 2007 Peanut allergy, peanut allergens, and methods for the detection of peanut contamination in food products Compr Rev Food Sci Food Saf 6(2): 47–58 Wilson S et al 2005 Allergenic proteins in soybean: processing and reduction of P34 allergenicity Nutr Rev 63(2): 47–58 Wolff N et al 2003 Allergy to sesame in humans is associated primarily with IgE antibody to a 14 kDa 2S albumin precursor Food Chem Toxicol 41(8): 1165–1174 Yazdanbakhsh M et al 2002 Allergy, parasites, and the hygiene hypothesis Science 296: 490–494 Yeung J 2006 Enzyme-linked immunosorbent assays (ELISAs) for detecting allergens in foods In: K Stef, H Sue (eds.) Detecting Allergens in Food Woodhead Publishing, Cambridge, pp 109–124 Yman IM et al 1994 Analysis of food proteins for verification of contamination or mislabelling Food Agric Immunol 6: 167–172 Yman IM et al 2006 Food allergen detection with biosensor immunoassays J AOAC Int 89: 856–861 Yu CJ et al 2003 Proteomics and immunological analysis of a novel shrimp allergen (Pen m 2) J Immunol 170: 445–453 Yunginger JW 1990 Classical food allergens Allergy Asthma Proc 11(1): 7–9 Zhang JW, Mine Y 1998 Characterization of IgE and IgG epitopes on ovomucoid using egg white allergic patient’s sera Biochem Biophys Res Commun 253: 124–127 Zhang X et al 2003 Soy food consumption is associated with lower risk of coronary heat disease in Chinese women J Nutr 133(9): 2874–2878 P1: SFK/UKS BLBS102-c43 P2: SFK BLBS102-Simpson March 21, 2012 14:30 Trim: 276mm X 219mm Printer Name: Yet to Come 43 Biogenic Amines in Foods Angelina O Danquah, Soottawat Benjakul, and Benjamin K Simpson Introduction Basic Structure and Formation Occurrence in Food Products Fermented Food Sources Cheese Alcoholic Beverages Meat Products Vegetable Products Non-fermented Foods Fish Meat Significance to the Food Industry Health Effects Quality Indicators Analysis Methods Extraction and Chromatography Fluorometric Methods Biosensors Enzyme-Linked Immunosorbent Assay Effects of Food Processing and Storage Evisceration Temperature Control Salting Smoking Regulations Conclusion References Abstract: Biogenic amines (also known as biologically active amines) are low-molecular weight organic compounds produced in biological systems by enzymatic decarboxylation of certain amino acids such as histamine and tyrosine Examples include dopamine, histamine, norepinephrine, serotonin, and tyramine They function in the body as neurotransmitters and relay signals between neurons across synapses to impact on mental functions, blood pressure, body temperature, appetite, and several other physiological processes The levels of biogenic amines in the body are regulated for proper functioning of the various physiological processes that they are associated with Certain foods contain biogenic amines that can add to the amounts naturally present in the body High intake of these foods could upset the balance of biogenic amines in the body to cause health problems such as hypotension, hypertension, gastrointestinal distress, headaches and migraine, and others Thus, it is crucial to curtail the formation and levels of these compounds in certain food products This chapter discusses the formation and occurrence of biogenic amines in selected food products, their effects of human health and significance to the food industry, their detection, and their fate during processing and storage The chapter also covers regulation of biogenic amines in foods INTRODUCTION Biogenic amines, also known as biologically active amines, are nitrogen-containing low-molecular weight organic compounds that are naturally present in food products such as cheese, wine, beer, plant food, fish, and meat (Tarjan and Janossy 1978) These substances are described as biogenic because they are formed by the action of living organisms In foodstuffs, they are perceived as undesirable anti-nutritional factors of public health concern since they have been associated with food poisoning (Shalaby 1996), particularly when ingested in large quantities, or where there is inhibition of their breakdown in humans Examples of biogenic amines are the catecholamines and indoleamines The prominent ones include acetylcholine (ACh), histamine, tyramine, dopamine (Fig 43.1), serotonin (Fig 43.2), norepinephrine (NE; also known as noradrenalin (NA)), and epinephrine (or adrenalin; Fig 43.3) Acetylcholine, also known as 2-acetoxy-N,N,Ntrimethylethanaminium, is a neuromodulator found in both the peripheral and the central nervous systems (PNS and CNS) The compound has a chemical formula of CH3 COOCH2 CH2 N+ (CH3 )3 and is formed from the esterification of choline with acetic acid in a reaction catalyzed by Food Biochemistry and Food Processing, Second Edition Edited by Benjamin K Simpson, Leo M.L Nollet, Fidel Toldr´a, Soottawat Benjakul, Gopinadhan Paliyath and Y.H Hui C 2012 John Wiley & Sons, Inc Published 2012 by John Wiley & Sons, Inc 820 ... Institute of Food Techologists’ expert panel on food safety and nutrition Food Technol 55(9): 68? ?? 83 Taylor SL, Lehrer SB 1996 Principles and characteristics of food allergens Crit Rev Food Sci Nutr... 112–114 81 9 Walsh BJ et al 1 988 New allergens from hen’s egg white and egg yolk: in vitro study of ovomucin, apovitellenin I and VI, and phosvitin Int Arch Allergy Appl Immunol 87 : 81 ? ?86 Walsh... BLBS102-Simpson 81 8 March 21, 2012 14:27 Trim: 276mm X 219mm Printer Name: Yet to Come Part 8: Food Safety and Food Allegens Oliver S, Vieths S 2004 Development of a real-time PCR and a sandwich ELISA