Risk of singleton preterm birth after prior twin preterm birth a cohort study Full Terms Conditions of access and use can be found at httpsndfonline comactionjournalInformation?journalCod.Risk of singleton preterm birth after prior twin preterm birth a cohort study Full Terms Conditions of access and use can be found at httpsndfonline comactionjournalInformation?journalCod.
The Journal of Maternal-Fetal & Neonatal Medicine ISSN: 1476-7058 (Print) 1476-4954 (Online) Journal homepage: https://www.tandfonline.com/loi/ijmf20 Risk of singleton preterm birth after prior twin preterm birth: a cohort study Rebecca Menzies, Adrienne L K Li, Kellie E Murphy, Prakesh S Shah, Daphne Horn, Jon Barrett & Nir Melamed To cite this article: Rebecca Menzies, Adrienne L K Li, Kellie E Murphy, Prakesh S Shah, Daphne Horn, Jon Barrett & Nir Melamed (2019): Risk of singleton preterm birth after prior twin preterm birth: a cohort study, The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2019.1581166 To link to this article: https://doi.org/10.1080/14767058.2019.1581166 Published online: 22 Feb 2019 Submit your article to this journal Article views: View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=ijmf20 THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE https://doi.org/10.1080/14767058.2019.1581166 ORIGINAL ARTICLE Risk of singleton preterm birth after prior twin preterm birth: a cohort study Rebecca Menziesa,b,c, Adrienne L K Lia,b, Kellie E Murphya,b, Prakesh S Shahd,e, Daphne Hornb,f, Jon Barretta,g and Nir Melameda,g a Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada; bDepartment of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Canada; cDepartment of Obstetrics and Gynecology, Trillium Health Partners, Mississauga, Canada; d Department of Paediatrics, Mount Sinai Hospital, Toronto, Canada; eDepartment of Paediatrics, University of Toronto, Toronto, Canada; fSidney Liswood Library, Mount Sinai Hospital, Toronto, Canada; gDepartment of Obstetrics and Gynaecology, Sunnybrook Health Sciences Centre, Toronto, Canada ABSTRACT ARTICLE HISTORY Objective: To determine whether preterm birth in a twin pregnancy increases the risk of subsequent preterm birth (PTB) in a singleton pregnancy and to identify predictors for singleton PTB in women with previous twin PTB Method: A retrospective cohort study of women with prior twin birth followed by a singleton birth in two tertiary referral centres between 2000 and 2016 was conducted Rate of PTB in subsequent singleton pregnancy was compared between women who experienced previous preterm versus term twin birth Analysis was further stratified by gestational age at twin and singleton birth, etiology for PTB and chorionicity in the twin pregnancy Results: A total of 378 women met the inclusion criteria, of whom 252 (66.7%) experienced PTB in the index twin pregnancy The overall rate of PTB in the subsequent singleton pregnancy was 11.6% (44/378) Women with prior twin PTB had a higher rate of PTB in the subsequent singleton pregnancy compared with women with prior term twin birth (17.5 versus 6.3%, p ¼ 003, or 3.12, 95%-CI 1.42–6.85), mainly due to a higher rate of late singleton preterm birth (13.1 versus 4.0%, p ¼ 005) Findings of higher odds of PTB in the subsequent singleton pregnancy was limited to women who gave birth before 340/7 weeks in the twin pregnancy and was related to the degree of prematurity (prior twin PTB at 300/7–336/7 weeks: OR 3.09, 95%-CI 1.12–8.51; prior twin PTB at