Predictive value of the sFlt 1 and PlGF in women at risk for preeclampsia in the south of Vietnam Accepted Manuscript Predictive value of the sFlt 1 and PlGF in women at risk for preeclampsia in the s.
Accepted Manuscript Predictive value of the sFlt-1 and PlGF in women at risk for preeclampsia in the south of Vietnam Trung Huu Nguyen, Thanh Cong Bui, Tuan Minh Vo, Quan Minh Tran, Loan Thi-Thanh Luu, Tai Duy Nguyen PII: DOI: Reference: S2210-7789(18)30072-2 https://doi.org/10.1016/j.preghy.2018.07.008 PREGHY 481 To appear in: Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health Received Date: Revised Date: Accepted Date: March 2018 July 2018 26 July 2018 Please cite this article as: Nguyen, T.H., Bui, T.C., Vo, T.M., Tran, Q.M., Luu, L.T-T., Nguyen, T.D., Predictive value of the sFlt-1 and PlGF in women at risk for preeclampsia in the south of Vietnam, Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health (2018), doi: https://doi.org/10.1016/j.preghy 2018.07.008 This is a PDF file of an unedited manuscript that has been accepted for publication As a service to our customers we are providing this early version of the manuscript The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain Full title: Predictive value of the sFlt-1 and PlGF in women at risk for preeclampsia in the south of Vietnam Authors: Trung Huu Nguyena, MD, PhD; Thanh Cong Buib, MD, DrPH; Tuan Minh Vo,a MD, PhD; Quan Minh Tranc, MD; Loan Thi-Thanh Luud, MD, MS; Tai Duy Nguyena, MD, PhD a Department of Obstetrics and Gynecology, University of Medicine and Pharmacy at Ho Chi Minh City Address: 217 Hong Bang Street, Ward 11, District 5, Ho Chi Minh City, Vietnam (First author emails: drtrung@ump.edu.vn, nguyenhuutrung@gmail.com; telephone: 084913931988) b Department of Family and Preventive Medicine, The University of Oklahoma Health Sciences Center Address: 655 Research Parkway, Suite 400, Oklahoma City, Oklahoma, 73104, United States Emails: thanh-c-bui@ouhsc.edu, thanh.bui@aya.yale.edu Telephone: 1-405-271-8001 ext 50559 c Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam Email: quantm@oucru.org, tranminhquan12332192@gmail.com Telephone: +84 39237954 d Tu Du Hospital Address: 284 Cong Quynh Street, District 1, Ho Chi Minh City, Vietnam Email: luuloan123@gmail.com Telephone: 084-913935051 Corresponding author: Thanh Cong Bui, MD, DrPH, Assistant Professor of Research Department of Family and Preventive Medicine, College of Medicine, The University of Oklahoma Health Sciences Center Address: 655 Research Parkway, Suite 400, Oklahoma City, Oklahoma, 73104, United States Emails: thanh-c-bui@ouhsc.edu, thanh.bui@aya.yale.edu Telephone: 1-405-271-8001 ext 50559 Suggested running head: Predictive value of the sFlt-1 and PlGF in preeclampsia Abstract Word Count: 250 Manuscript Word Count: 2589 Number of tables: Number of figures: Abstract Background: It has been suggested that soluble fms-like tyrosine kinase receptor-1 (sFlt-1) and placental growth factor (PlGF) play potential roles in preeclampsia diagnosis Nevertheless, studies on the use of sFlt-1, PlGF, and sFlt-1/PlGF ratio in predicting preeclampsia have found contradictory results Thus, more studies in different populations are needed Objectives: This study aims to (i) examine the associations between sFlt-1, PlGF, or sFlt-1/PlGF ratio at gestational ages of 24-28 weeks and subsequent preeclampsia, and (ii) estimate predictive values of these markers in southern Vietnamese women Methods: We used a nested case-control design from a cohort of 490 pregnant women who were at risk of preeclampsia The total sample size for statistical analysis consisted of 30 cases and 67controls Levels of sFlt-1 and PlGF were quantified by using a fully automated electrochemiluminescence immunoassay platform (Elecsys®/Cobas®) Results: The median of sFlt-1 concentration was not statistically different between case and control groups The median PlGF concentration was lower (349.7 pg/ml versus 534.6 pg/ml, P