e-TABLE 94.8 INFECTIOUS DISEASES SOCIETY OF AMERICA AND AMERICAN THORACIC SOCIETY GUIDELINES FOR ASSESSING DISEASE SEVERITY IN CHILDREN WITH COMMUNITY-ACQUIRED PNEUMONIA a Major Minor Invasive mechanical ventilation Fluid-refractory shock Acute need for noninvasive positive-pressure ventilation Hypoxemia requiring supplemental oxygen concentration or flow beyond what is feasible in a general ward setting Tachypnea Apnea Increased work of breathing Pao2 /FiO2 ratio 6 Altered mental status Hypotension Presence of pleural effusion Comorbid conditions (e.g., sickle cell anemia, immunodeficiency, or immunosuppression) Unexplained metabolic acidosis a The clinician should consider intensive care unit care for children with ≥1 major or ≥2 minor criteria PaO2 , arterial oxygen pressure; FiO2 , fraction of inspired oxygen; PEWS, pediatric early warning score