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• Rash: generalized erythematous macular; may desquamate • Soft tissue necrosis (necrotizing fasciitis or myositis, or gangrene) • Renal: BUN or creatinine at least 2ì ULN or pyuria ã Hepatic: total bilirubin, ALT, or AST at least 2ì ULN ã Coagulopathy: platelets

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