Definite evaluation by slit lamp examination is necessary to determine etiology CT may be required for some infants to delineate orbital structures, shape of the globe, and other cranial anomalies Therefore, all infants with an abnormal pupillary light reflex should be referred to an ophthalmologist for a prompt evaluation Treatment depends on the underlying etiology FIGURE 96.28 Unilateral leukocoria in a newborn with congenital rubella This child has congenital rubella syndrome Although full term, the baby is small for his gestational age There is leukocoria due to a cataract in the left eye (Reprinted with permission from Garg S Color Atlas and Synopsis of Clinical Ophthalmology—Wills Eye Institute—Uveitis Philadelphia, PA: Lippincott Williams & Wilkins; 2011.)