FIGURE 66.14 Candida infection Note the intense confluent area of inflammation surrounded by discrete satellite lesions (Reprinted with permission from Sauer GC, Hall JC Manual of Skin Diseases 7th ed Philadelphia, PA: Lippincott-Raven; 1996.) Localized candidal infections in healthy full-term infants often present in diaper, axillary, or other warm moist environments In addition to therapy with topical antifungal agents, allowing the folds to dry is important to prevent reinfection Opportunistic Fungal Infections There are some fungi and yeasts that should not grow in patients with normal immunity under normal circumstances Therefore, infection with these opportunistic pathogens should warrant a workup for immunosuppression Fungi such as Aspergillus species, and molds such as mucormycosis (including Rhizopus species), Fusarium species, alternaria , and others can either cause infection by direct inoculation of the skin or by dissemination to the skin from a distant systemic infection in immunosuppressed patients Infection through direct cutaneous inoculation presents with an eschar or deep purple nodule The purple color is caused by vascular invasion or