remodeling and failure: from molecules to man (part III) Cardiovasc Pathol 2005;14:109–119 Li G, Willerson JT Molecular biological alterations in heart failure Frazier OH Support and Replacement of the Failing Heart Lippincott-Raven: Philadelphia; 1996:69–74 Suga H Time course of left ventricular pressurevolume relationship under various enddiastolic volume Jpn Heart J 1969;10:509–515 Suga H Theoretical analysis of a left-ventricular pumping model based on the systolic timevarying pressure-volume ratio IEEE Trans Biomed Eng 1971;18:47–55 10 Baan J, Jong TT, Kerkhof PL, et al Continuous stroke volume and cardiac output from intraventricular dimensions obtained with impedance catheter Cardiovasc Res 1981;15:328–334 11 Wiggers CJ Studies in the consecutive phases of the cardiac cycle Am J Physiol 1921;56:415– 459 12 Sunagawa K, Sagawa K, Maughan WL Ventricular interaction with the loading system Ann Biomed Eng 1984;12:163–189 13 Suga H Ventricular energetics Physiol Rev 1990;70:247–277 14 Asanoi H, Sasayama S, Kameyama T Ventriculoarterial coupling in normal and failing heart in humans Circ Res 1989;65:483–493 15 Sasayama S, Asanoi H Coupling between the heart and arterial system in heart failure Am J Med 1991;90:14S–18S 16 Bleeker GB, Bax JJ, Steendijk P, et al Left ventricular dyssynchrony in patients with heart failure: pathophysiology, diagnosis and treatment Nat Clin Pract 2006;3:213–219 17 Towbin JA, Bowles NE Dilated cardiomyopathy: a tale of cytoskeletal proteins and beyond J Cardiovasc Electrophysiol 2006;17:919–926 18 Bers DM, Despa S, Bossuyt J Regulation of ca2+ and na+ in normal and failing cardiac myocytes Ann N Y Acad Sci 2006;1080:165– 177 19 Katz AM Protein families that mediate ca2+ signaling in the cardiovascular system Am J Cardiol 1996;78:2–6 20 Cooper GT Cytoskeletal networks and the regulation of cardiac contractility: microtubules, hypertrophy, and cardiac dysfunction Am J Physiol Heart Circ Physiol 2006;291:H1003– H1014 21 Ehler E, Perriard JC Cardiomyocyte cytoskeleton and myofibrillogenesis in healthy and diseased heart Heart Fail Rev 2000;5:259– 269 22 Kostin S, Hein S, Arnon E, et al The cytoskeleton and related proteins in the human failing heart Heart Fail Rev 2000;5:271–280 23 Goffart S, von Kleist-Retzow JC, Wiesner RJ Regulation of mitochondrial proliferation in the heart: Power-plant failure contributes to cardiac failure in hypertrophy Cardiovasc Res 2004;64:198–207 24 Das DK, Maulik N Mitochondrial function in cardiomyocytes: target for cardioprotection Curr Opin Anaesthesiol 2005;18:77–82 25 Marin-Garcia J, Goldenthal MJ Heart mitochondria signaling pathways: appraisal of an emerging field J Mol Med (Berlin) 2004;82:565–578 26 Lev D, Nissenkorn A, Leshinsky-Silver E, et al Clinical presentations of mitochondrial cardiomyopathies Pediatr Cardiol 2004;25:443–450 27 Towbin JA The role of cytoskeletal proteins in cardiomyopathies Curr Opin Cell Biol 1998;10:131–139 28 Tardiff JC Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes Heart Fail Rev 2005;10:237–248 29 Towbin JA Inflammatory cardiomyopathy: there