Andersons pediatric cardiology 1493

Endocarditis in Severely Ill Children Antibiotics Usual Dose Comments NATIVE VALVE (COMMUNITY ACQUIRED) OR LATE PROSTHETIC VALVES (≥12 MONTHS POSTSURGERY) Amoxycillin/ampicillin 200–300 In penicillin allergy, use vancomycin and plus mg/kg/day in 4–6 gentamicin divided doses In areas of high risk of MRSA some authorities combine flucloxacillin with vancomycin and Flucloxacillin 200–300 gentamicin empirically plus mg/kg/day in 4–6 divided doses Gentamicin 3 mg/kg once daily Vancomycin 40–60 Penicillin allergy plus Gentamicin mg/kg/day in Known MRSA or high risk plus Rifampicin 3–4 divided Consider adding rifampicin where there is prosthetic doses valve/material 3 mg/kg once daily 10 mg/kg twice daily EARLY PVE (