Multi elution, disposable cartridge based radioisotope concentrator device for increasing 99mtc and 188re concentration of commercial radionuclide generator eluates

12346789 89 8  8889  !"#$%&'()*!)+&(,!-'./01234567(($08960:/ ;< 24=>?@AB 85% using this radioisotope concentrator device repeated elutions were successfully performed with each cartridge So, each cartridge can be effectively used for one week in the hospital environment for radiopharmaceutical formulation The useful lifetime of the 99mTc generator was significantly extended depending on the activity of the generator as shown in below table The 99Mo impurity detectable in the 99mTc solution eluted from the Gentech generator (Fig 1b) was totally eliminated by this radioisotope concentrator device and ultra-pure, concentrated 99mTc-pertechnetate solution was achieved The concentrated 99mTc solution is well suited to labeling in-vivo kits and to loading the crucibles of Technegas generators for V/Q SPECT imaging Conclusion: We conclude that the radioisotope concentrator device functioned well and is robust in operation This is a user-friendly and effective device for extending the operational lifetime of generators by providing a concentrated 99mTc/188Re solution which can be used in Technegas V/Q SPECT lung perfusion and other SPECT imaging This device will, to some extent, mitigate the global 99mTc crisis The material is a work-in-progress and patent-pending References: [1] Le V.S, McBrayer J., Morcos N., (2012) Australian patent AU2012904683 ULTRALUTE MULTI-USE RADIOISOTOPE CONCENTRATOR ACHIEVING A TEN-FOLD INCREASE IN ELUATE CONCENTRATION • Elute Tc-99m or Re-188 • Concentrates eluate to 1ml • Fast elution rate • Multi-use disposable cartridge Can fit all generators for in-line elution Permits high specific activity elution thereby extending useable life of Tc generator Delivers super quality eluate leading to higher labelling efficiency Option to use a smaller Tc-99m generator for further cost savings Radioactivity of generator, mCi ( GBq) g -Spectrum of Tc-99m eluate a: with and b: without concentrator Disposable cartridge unit 100 (3.7) 300 (11.1) 500 (18.5) 1000 (37.0) 3000 (111.0) Life-time of generator useful for clinical SPECT imaging (Days) Without 99mTc With post-elution concentration concentration of 99mTc 10 12 15 14 20 Cartridge installed in unit Life-time of generator useful for the Cyclomedica Technegas Generator (Days) Without 99mTc With post-elution concentration concentration of 99mTc 14 Concentrator with standard accessories NUCLEAR MEDICINE View publication stats