Leprosy (Hansen’s Disease)

Leprosy (Hansen’s Disease) Leprosy (Hansen’s Disease) Brought to you by Leprosy is caused by Mycobacterium leprae Scollard, DM et al 2006 “The continuing challenges of leprosy ” Clinical microbiology.

Leprosy (Hansen’s Disease) Brought to you by Leprosy is caused by Mycobacterium leprae rd, DM et al 2006 “The continuing challenges of leprosy.” Clinical microbiology reviews 19, no 2: 338-81 Brought to you by Discovered by Gerhard Armauer Hansen in 1873 Global Project on the History of Leprosy ://www.leprosyhistory.org/graphics/gallery/hansen.jpg Brought to you by Bacteria Resides in Cooler Parts of the Body Skin http://www.nlm.nih.gov Peripheral Brought to you by Nerves Symptoms & Diagnosis: (1) Skin Lesions Brought to you by Worobec, Sophie M 2009 “Treatment of leprosy/Hansen's disease in the early 21st century.” Dermatologic therapy 22, Symptoms & Diagnosis: (2) Skin Smear Tests Ziehl Neelsen Carbol Fuchsin Stain (ZNCF) Brought to you by Global Project on the History of Leprosy http://www.leprosyhistory.org/graphics/gallery/mleprae.jpg Transmission   Nasal/oral Droplets Dermal Inoculations Brought to you by Immunocompromised individuals are more susceptible to disease Brought to you by Mechanism of Nerve Damage ard, DM et al 2006 “The continuing challenges of leprosy.” Clinical microbiology reviews 19, no 2: 338-81 Entry Through Blood Vessels Inflammatory Response Demyelination Brought to you by Outcomes of Nerve Damage  Sensory Loss  Paralysis  Deformities Brought to you by Sensory Loss Can Lead to Secondary Infections and Severe Deformities Brought to you by 1941: Discovery of Dapsone  Targets dihydropteroate synthase (DHPS)  Inhibits nucleic acid synthesis Brought to you by 1964: Dapsone Resistance from Missense Mutations in DHPS Brought to you by 1960’s: Rifampicin and Clofazimine Discovered  Rifampicin (Rifampin): Inhibit RNA synthesis  Clofazimine: Anti-inflammatory Brought to you by 1981: WHO Proposes Multi-Drug Therapy (MDT)  Combination of DAPSONE, RIFAMPICIN, and CLOFAZIMINE + + Brought to you by Brought to you by 1995: WHO Distributes MDT Drugs for Free to Worldwide Patients Brought to you by 1999: Global Alliance to Eliminate Leprosy As a Public Health Problem Brought to you by Obstacles to Eliminating Leprosy in Endemic Countries STIGMA Brought to you by Overcoming Stigma   Mass Media Integrated Primary Health Services  Education & Training Brought to you by Brought to you by References Leprosy Today “Leprosy: The Disease.” World Health Organization http://www.who.int/lep/leprosy/en/index.html (accessed February 25 2010) Matsuoka, Masanori M 2010 “Drug Resistance in Leprosy.” Japanese journal of infectious diseases 63, no 1: 1-7 http://www.nih.go.jp.libproxy.lib.unc.edu (accessed February 25, 2010) National Hansen’s Disease (Leprosy) Program “Hansen’s Disease (Leprosy) Facts.” U.S Department of Health and Human Services http://www.hrsa.gov/hansens/ Accessed February 25 2010 Scollard, DM, LB Adams, TP Gillis, JL Krahenbuhl , RW Truman, and DL Williams 2006 “The continuing challenges of leprosy.” Clinical microbiology reviews 19, no 2: 33881 http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu (accessed February 25, 2010) Worobec, Sophie M 2009 “Treatment of leprosy/Hansen's disease in the early 21st century.” Dermatologic therapy 22, no 6: 518-37 http://www3.interscience.wiley.com.libproxy.lib.unc.edu (accessed February 25, 2010 Brought to you by This platform has been started by Parveen Kumar Chadha with the vision that nobody should suffer the way he has suffered because of lack and improper healthcare facilities in India We need lots of funds manpower etc to make this vision a reality please contact us Join us as a member for a noble cause Brought to you by Our views have increased the mark of the 20,000  Thank you viewers  Looking forward for franchise, collaboration, partners Brought to you by Contact 011- ,011-41425180 :-Us,011-25464531 66217387 91-+,91-9818308353+ 9818569476 othermotherindia@gm ail.com www.other-mother.in Saxbee Consultants Details :-www.parveenchadha.com https://cparveen.wix.com/other-mot her https://twitter.com/othermotheri ndi http://www.linkedin.com/profile/view?id=326103341&trk=nav_responsive_tab_pr ofile https://www.facebook.com/pages/Other-Mother-Nursing-Crusade/224235031114989 ?ref=hl A WORLDWIDE MISSITION Brought to you by JOIN US ... References Leprosy Today ? ?Leprosy: The Disease.” World Health Organization http://www.who.int/lep /leprosy/ en/index.html (accessed February 25 2010) Matsuoka, Masanori M 2010 “Drug Resistance in Leprosy. ”... to you by Discovered by Gerhard Armauer Hansen in 1873 Global Project on the History of Leprosy ://www.leprosyhistory.org/graphics/gallery/hansen.jpg Brought to you by Bacteria Resides in Cooler... Neelsen Carbol Fuchsin Stain (ZNCF) Brought to you by Global Project on the History of Leprosy http://www.leprosyhistory.org/graphics/gallery/mleprae.jpg Transmission   Nasal/oral Droplets Dermal