Pharmacology and Therapeutics of Cough doc

[...]... P (2008) Cough sensors I: TRP membrane receptors on cough sensors In: Chung KF, Widdicombe JG (eds) Pharmacology and therapeutics of cough, Handbook of experimental pharmacology, vol 187 Springer, Berlin Mazzone SB, Undem BJ (2008) Cough sensors IV: Pharmacological modulation of cough sensors In: Chung KF, Widdicombe JG (eds) Pharmacology and therapeutics of cough, Handbook of experimental pharmacology, ... cause of chronic cough Eur Respir J 23:199–201 Birring SS, Matos S, Patel RB, Prudon B, Evans DH, Pavord ID (2006) Cough frequency, cough sensitivity and health status in patients with chronic cough Respir Med 100:1105–1109 Bolser DC (2008) Central mechanisms II: Pharmacology of brainstem pathways In: Chung KF, Widdicombe JG (eds) Pharmacology and therapeutics of cough, Handbook of experimental pharmacology, ... Sensory neuropathic cough: A common and treatable cause of chronic cough Otolaryngol Head Neck Surg 135:17–21 Belvisi MG, Bolser DC (2002) Animal models for cough Pulm Pharmacol Ther 15:249–250 Belvisi MG, Hele DJ (2008) Cough sensors II: Opioid and cannabinoid receptors on vagal sensory nerves In: Chung KF, Widdicombe JG (eds) Pharmacology and therapeutics of cough, Handbook of experimental pharmacology, ... acute cough may be an irritation but is seldom a major cause of concern, while chronic cough can destroy the quality of life and arouse serious concerns in both patient and carer K.F Chung National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK f.chung@imperial.ac.uk K.F Chung, J.G Widdicombe (eds.), Pharmacology and Therapeutics of Cough, Handbook of Experimental Pharmacology. .. nerve subtypes mediating cough Pulm Pharmacol Ther 15:187–192 Canning BJ (2007) Encoding of the cough reflex Pulm Pharmacol Ther 20:396–401 Cough: Setting the Scene 17 Canning BJ, Chou Y-L (2008) Physiological and pharmacological properties of the afferent nerves regulating cough In: Chung KF, Widdicombe JG (eds) Pharmacology and therapeutics of cough, Handbook of experimental pharmacology, vol 187 Springer,... trials using validated measures of cough is urgently needed and the potential antitussive mechanisms need to be investigated 13 Conclusions: The Future of Cough In the next 10 years, we expect to continue to increase our understanding of the physiological mechanisms of acute and chronic cough, including from the point of view of peripheral and central sensitizations of the cough reflex From the clinical... associations of various diseases with chronic cough still need to be worked out carefully, and the mechanisms of cough in disease are in need of clarification Asthma may present predominantly with cough, often nocturnal, and the diagnosis is supported by the presence of bronchial hyperresponsiveness Three other conditions, cough- variant asthma, atopic cough, and eosinophilic bronchitis, are related Cough: ... underlying the enhanced cough response in chronic cough are illustrated in Fig 2 11 Measuring Cough There has been a great deal of progress made in the field of cough measurement over the last 10 years (Chung 2006) Cough can be measured subjectively using symptom scores and specific quality -of- life measures, and objectively by measuring cough numbers and intensity, and by assessing the cough response to capsaicin... (1989) Mechanics of cough In: Braga PC, AllegraL (eds) Cough Raven, New York, pp 29–36 Birring SS, Yousaf N (2008) Clinical Cough III: Measuring cough in the patient In: Chung KF, Widdicombe JG (eds) Pharmacology and therapeutics of cough, Handbook of experimental pharmacology, vol 187 Springer, Berlin Birring SS, Prudon B, Carr AJ, Singh SJ, Morgan MD, Pavord ID (2003) Development of a symptom specific... bring a wide variety of physiological, clinical, and therapeutic aspects of cough together, but with a minimum of overlap In general, it is true to say that the last decade or so has seen dramatic advances in our knowledge of the physiological mechanisms of acute cough in experimental animals, and that these are now moving in the direction of understanding increased sensitivity of cough in chronic conditions . organization of the cough centre’, and the involvement of the cerebral cortex in the sensations and the volun- tary control of cough. With the exception of the. UK f.chung@imperial.ac.uk K.F. Chung, J.G. Widdicombe (eds.), Pharmacology and Therapeutics of Cough, 1 Handbook of Experimental Pharmacology 187, c  Springer-Verlag Berlin