35 PEDs insulin

UNIVERSITY PEDs Insulin Deployment Lesson Overview AAS/GH/Insulin Synergy Insulin and Hypertrophy Endogenous verse Exogenous Insulin Why use exogenous insulin? When to implement exogenous insulin? Long Acting Basal Insulin Protocol Fast Acting Meal-time Insulin Protocol Should you cycle insulin? Precautions with insulin therapy? AAS + GH+ Insulin Synergy AAS effects: Testosterone alone increase GH/IGF-1 expression, while non/low aromatizing androgens causing much less of an impact (nandrolone/trenbolone) AI and SERM usage attenuate the effects of testosterone on GH/IGF-1, AI is less impactful on GH hepatic action than a SERM Increased GH receptor expression in skeletal muscle Increased local IGF-1 mRNA expression in skeletal muscle Nearly 95% of all circulating IGF-1 exists in a bound state (most bound to IGFBP-3, other isoforms) Binding proteins increase bioavailability, extend serum life Can inhibit or enhance IGF action AAS Decreased IGFBP-4 in local muscle, increase IGFBP-3 systemically GH effects: GH and AAS enhance collagen synthesis GH stimulated JAK/STAT5 pathway direct relationship with local IGF-1, this pathway is also downstream target for androgen receptor gene expression So, GH increase AR expression (GH makes your current AAS more effective) Insulin effects: Insulin has a permissive effect to optimize nutrient update and AAS GH/IGF-1 Synergies Insulin increases GHR, reverses IGF-1 desensitization, stimulates GH to IGF-1 expression There is also a desensitized refractory period within the JAK/STAT5 for ~5hours post GH administration where further administration does not cause same IGF-1 Response (Frost) Insulin can sensitize the JAK/STAT5 pathway to GH A meal between GH administration with an insulin increase would accomplish this AAS + GH+ Insulin Synergy Figure Mechanisms of action of GH, IGF-1, and insulin in skeletal muscle AAT, amino acid transporter Intramuscular anabolic mechanisms mediated by GH, IGF-1, and insulin providing the theoretical basis for use of these agents as PEDs (Anderson, 2017) GH and Insulin Resistance “Effects of Growth Hormone on Glucose Metabolism and Insulin Resistance In Human” (Kim 2017) review paper High dose GH usage >0.01mg/kg/day increase fasting glucose and insulin levels and increased insulin resistance, A1c remained relatively unchanged Low dose GH usage