Tài liệu Pharmaceutical Coating Technology (Part 7) doc

... 170 7 The coating process Graham C.Cole SUMMARY In recent years tablet coating has undergone several fundamental changes. The original sugar -coating technique has been largely replaced by film -coating ... parts of the equipment can provide a reduction in the overall coating cycle. 7.1 PROCESS DEVELOPMENT OF AQUEOUS FILM COATING Coating of tablets and pills is one of the oldest...

Ngày tải lên: 22/01/2014, 00:20

... nature and formulation of the coating system also affect this property. Coating equipment design A variety of coating pans are commercially available for aqueous film coating. These have been reviewed ... is the coating of powders, granules and spherical pellets. The Accela- Cota is the coating pan most widely used presently within the pharmaceutical industry for aqueous tabl...

Ngày tải lên: 22/01/2014, 00:20

... Page 427 14.5 ENTERIC COATINGS 14.5.1 Introduction and rationale for use These coatings form a subgroup of modified release coatings and a simple definition of such a coating would be one that ... minimum effective level of enteric -coating agent. 14.5.5 Ideal enteric coatings An enteric coating must possess the general attributes of a non-functional film coating (see Chapter 2) w...

Ngày tải lên: 22/01/2014, 00:20

... some aqueous-based tablet film coating polymer systems. Pharm. Res. 2, 19–23. Okhamafe, A.O. & York, P. (19 87) Interaction phenomena in pharmaceutical film coatings and testing methods. ... pharmaceutical film coating. Coating is a very extensive subject and so this bibliography is restricted to those publications of direct pharmaceutical relevance or authorship. Non-...

Ngày tải lên: 26/01/2014, 19:20

... • Sugar coating • Film coating • Particulate/pellet coating • Compression coating. Page i Pharmaceutical Coating Technology Page 3 one hundred of these pans to be installed in a coating department. ... The coating process Graham C.Cole Summary 170 7.1 Process development of aqueous film coating 170 7.2 Theoretical considerations of film coating 172 7.3 The mec...

Ngày tải lên: 24/12/2013, 18:15

... Pharm. 48, 63–77. Handbook of Pharmaceutical Excipients (1986) American Pharmaceutical Association, Washington and Royal Pharmaceutical Society, London. Hansen, C.M. (19 67) J. Paint Technol. 39, ... Sims, S. (19 87) Drug Dev. Ind. Pharm. 13, 2209–2219. Spitael, J. & Kinget, R. (19 77) J. Pharm. Belg. 32, 569–577. Steuernagel, C.R. (1989) In Aqueous polymeric coating...

Ngày tải lên: 24/12/2013, 18:15

... steps involved in sugar coating are covered in som e detail, i.e. sealing, subcoating, smoothing, colour coating, polishing and printing. In the section dealing with subcoating several suitable ... the dosage form. 3.1 INTRODUCTION The pharmaceutical process of sugar coating remains a widely practised technology despite the interest arising from film -coating techniques since...

Ngày tải lên: 24/12/2013, 18:15

... practice in pharmaceutical coating, the ability of the coating equipment to evaporate the solvent satisfactorily may be overcome and the product overwetted, resulting in poor-quality coatings. ... granule or multiparticulate film coating to date, since those available either have difficulty in coping with the flow rates required for either organic or aqueous film coating, produce d...

Ngày tải lên: 24/12/2013, 18:15

... process of film coating of pharmaceutical solid dosage forms, one cannot escape a consideration of surface aspects relating to the wetting of granule, pellet or tablet cores by the coating solution ... to produce much more efficient and elegant films. Film coatings are invariably applied in the pharmaceutical industry by spraying a coating solution or suspension onto the surface...

Ngày tải lên: 24/12/2013, 18:15

... designed for aqueous film coating in a side-vented pan. A comparison is made of energy requirements of a column -coating system and a coating pan. All the major operational coating parameters can ... Q=GC p .ΔT=9010×0.25×4.2×40 Table 6.3 Energy balance: comparison of a 1500 mm diameter coating pan and a 450 mm fluidized bed coating column 1500 mm coating pan 450 mm column...

Ngày tải lên: 24/12/2013, 18:15