Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 21)

... 3.4 206 Morphine and its analogues 8) Matsubara K, Fukushima S, Akane A et al. (1992) Increased urinary morphine, codeine and tetrahydropapavero- line in Parkinsonian patient undergoing L-3,4-dihydroxyphenylalanine ... conjugated forms of opiates, the authentic standards of mor- phine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G) are necessary. In U.S .A. and Eur...

Ngày tải lên: 24/10/2013, 19:15

... mg/mL), and kept airtightly in a refrigerator. A 5- L volume of the above solution is placed using a microsyringe in a glass vial containing 1 mL of dimethyl sulfoxide (DMSO), capped airtightly and ... transformation in rats. J Pharm Sci 74:780–782 10) Kielbasa WB, Bauer JA, Fung HL (1999) Analysis of isobutyl nitrite inhalant in rat and human blood: applica...

Ngày tải lên: 18/10/2013, 00:15

... done inside a dra chamber. f) For quantitative analysis of DAEMS, various concentrations of DAEMS are spiked into blank serum specimens containing a  xed amount of DAEMO (IS) each and extracted ... DAEMS consisting of peak area ratio of DAEMS to IS on the vertical axis and DAEMS concentration on the horizontal axis. A peak area ratio obtained from a test specimen...

Ngày tải lên: 18/10/2013, 00:15

... GC/MS analysis of ∆ 9 -THC-11-oic acid in urine 188 Cannabinoids and their metabolites GC analysis of cannabinoids in plant specimens a Reagents and their preparation • Extraction and puri cation ... disposition, and kinetics of delta-9-tetrahydrocannabinol in men and women. Clin Pharmacol Ther 34:352–363 2) Agurell S, Halldin M, Lindgren J-E et al. (1986) Phar...

Ngày tải lên: 24/10/2013, 19:15

... methemoglobinemia be- comes severe, it causes cyanosis, headache, easy fatigability, respiratory and conciousness dis- turbances and  nally death.  e fatal methemoglobinemia is rare, but fatal ones a ... (1987) Cyanosis in infants caused by nitrates in well water. JAMA 257:2788–2792 12) Fan AM, Steinberg VE (1996) Health implications of nitrate and nitrite in drinking water:...

Ngày tải lên: 24/10/2013, 19:15

... 385 1-amino- 4- phenylbutane 173 2-amino-6-hydroxymethyl- 8-hydroxyquinazoline 482 aminomethyl phosphonic acid 546 7-aminonitrazepam 19 5-aminoquinoline 499 amitriptyline 271, 274, 276 amniotic ... 327 N-de-ethyl-LSD 228 n-decane 165 n-heptane 165 n-hexane 165 N-methyl- 1-( 3,4-methylene- dioxyphenyl )-2 -butan- amine 229 N-methyl- 1-( 3,4-methylene- dioxyphenyl )-3 -butan- am...

Ngày tải lên: 24/10/2013, 19:15

... mass spectra of the authentic cocaine, EME and BE a er derivatization. Setting up of cuto values are very common in USA and Europe as a part of QC ( quality control) and QA ( quality assurance) ... of BE in blood, a satisfactory mass spectrum can be obtained. For BE, Metabolic pathways of cocaine. ⊡ Figure 4.4 Toxic and fatal concentrations 212 Cocaine and its...

Ngày tải lên: 29/10/2013, 01:15

... concentration in the horizontal axis and peak area ratio of pentazocine to IS in the vertical axis.  e peak area ratio of a test specimen is applied to the calibration curve to obtain its pentazocine ... Dextromethorphan-HBr to be used as internal standard (IS) was purchased from Sigma; Sep-Pak C 18 cartridges (classic type) from Waters 222 Pentazocine SIM chromatograms for...

Ngày tải lên: 29/10/2013, 02:15

... digestive tract is rapid and distinct visual hallucination takes place 45 min–1 h a er oral intake of about 20 µg of LSD [1].  e hallucination becomes most marked 2–3 h a er the intake and lasts ... powerful hallucinogenic drugs of abuse. LSD was explosively abused in U.S .A. in the latter half of the 1960s. In Japan, the amount of seizure of LSD is much smaller...

Ngày tải lên: 08/11/2013, 01:15

... MDAs and their main metabolites 4-hydroxy-3-me- thoxymethamphetamine ( HMMA) and 4-hydroxy-3-methoxyamphetamine ( HMA) in urine specimens are presented. Metabolic pathways for MDMA and MDA. ⊡ ... H, Nakajima K, Nishikawa M et al. (1991) Determination of methamphetamine and amphetamine in urine by headspace gas chromatography/mass spectrometry. Anal Sci 7:19–22 25) Shima N, Kam...

Ngày tải lên: 08/11/2013, 01:15