health effects of asbestos exposure in humans a quantitative assessment

Ngày tải lên: 17/02/2014, 11:20

Ngày tải lên: 18/06/2014, 17:20

Ngày tải lên: 13/08/2014, 14:20

... consisting of the concentration of an alkyl nitrite on the horizontal axis and peak area on the vertical axis.  e concentration of the analyte in a specimen is calculated using the calibration curve. Assessment ... transformation in rats. J Pharm Sci 74:780–782 10) Kielbasa WB, Bauer JA, Fung HL (1999) Analysis of isobutyl nitrite inhalant in rat and human blood: application for pharmacokinetic investigations. ... mg/mL), and kept airtightly in a refrigerator. A 5-àL volume of the above solution is placed using a microsyringe in a glass vial containing 1 mL of dimethyl sulfoxide (DMSO), capped airtightly and...

Ngày tải lên: 18/10/2013, 00:15

... For quantitative analysis of DAEMS, various concentrations of DAEMS are spiked into blank serum specimens containing a  xed amount of DAEMO (IS) each and extracted as described before. Since ... gradually and carefully. If VX itself remains, there is a danger of the secondary exposure for an analyst; the manipulations including the above evaporation should be done inside a dra chamber. f) ... base peaks of DAEMS and DAEMO (IS) equally appear at m/z 114, the SIM measurements should be made using this single ion to construct a cali- bration curve for DAEMS consisting of peak area ratio...

Ngày tải lên: 18/10/2013, 00:15

... GC/MS analysis of ∆ 9 -THC-11-oic acid in urine 188 Cannabinoids and their metabolites GC analysis of cannabinoids in plant specimens a Reagents and their preparation ã Extraction and puri cation ... resin of the cannabis plant. Since the main component of cannabis, ∆ 9 -tetrahydrocannabi- nol ( ∆ 9 -THC), has various psychopharmacological e ects including hallucination, the can- nabis and ... CBD, CBN and 5α-cholestane. GC analysis of cannabinoids in plant specimens 192 Cannabinoids and their metabolites  e Substance Abuse and Mental Service Administration (SAMSA) in USA set the...

Ngày tải lên: 24/10/2013, 19:15

... Matsubara K, Fukushima S, Akane A et al. (1992) Increased urinary morphine, codeine and tetrahydropapavero- line in Parkinsonian patient undergoing L-3,4-dihydroxyphenylalanine therapy: a possible ... for diagnosis of heroin use, because of its relatively long half-life in the body [4]. For accurate diagnosis of a cause of death in an opiate poisoning case, the ratio of a free form to a conjugated ... urinalysis: a closer look. J Anal Toxicol 14:308–310 10) Hasegawa M, Maseda C, Kagawa M et al. (1992) Morphine and codeine being contained in poppy seeds and poppy seed-containing foods. Eisei Kagaku...

Ngày tải lên: 24/10/2013, 19:15

... (1987) Cyanosis in infants caused by nitrates in well water. JAMA 257:2788–2792 12) Fan AM, Steinberg VE (1996) Health implications of nitrate and nitrite in drinking water: an update on methe- moglobinemia ... (1996) A case of severe methemoglobinemia for a newborn baby caused by well water. Jpn J Pediatr 49:1661–1665 (in Japanese) 4) Saito T, Takeichi S, Osawa M et al. (2000) A case of fatal methemoglobinemia ... methemoglobinemia be- comes severe, it causes cyanosis, headache, easy fatigability, respiratory and conciousness dis- turbances and  nally death.  e fatal methemoglobinemia is rare, but fatal ones a ...

Ngày tải lên: 24/10/2013, 19:15

... 285, 290 alternative specimens 9 Amanita neoovoidea 480 Amanita pantherina 469 Amanita phalloides 469 Amanita verna 469, 474 Amanita virosa 469, 473 amanitin 473, 477, 479 amido-type local anesthetic ... 137 aldicarb 566 aldrin 529 alkylated adducts 85 alkylated DNAs 85 alkylation 30 alkyl nitrites 153, 655 allobarbital 305, 308 allylesterase 624 allyxycarb 566 alminoprofen 325, 330, 332 alprazolam ... phenomenon that the absorbance maximum of weakly acidic Met-Hb at 630 nm disappears by addition of cyanide. Met-Hb concentration can be easily determined as the ratios of the absorbance changes in- duced...

Ngày tải lên: 24/10/2013, 19:15

... for urine sampled 0–1 h a er cocaine inhalation; the ratio was 10.6 on average for urine sampled 0–8 h a er the inhalation.  e ratios increased according to the increase in time interval between ... fatal levels of cocaine in literature probably due to the above factors.  e fatal doses are, of course, di erent according to administration routes. Usually, the oral fatal dose for humans ... USA, but in Japan the number of such cases is limited.  e author et al. experienced a fatal cocaine poisoning case and measured concentrations of cocaine and its metabolites in body  uids and...

Ngày tải lên: 29/10/2013, 01:15

... concentration in the horizontal axis and peak area ratio of pentazocine to IS in the vertical axis.  e peak area ratio of a test specimen is applied to the calibration curve to obtain its pentazocine ... Determination of pentazocine in human plasma by high performance liquid chromatography. Pharmazie 46:464–465 8) Seno H, Kumazawa T, Ishii A et al. (2000) Determination of pentazocine in human whole ... and phencyclidine in human plasma using capillary gas chromatography. Method Find Exp Clin Pharmacol 12:193–196 4) Hattori H, Suzuki O, Seno H et al. (1993) Sensitive determination of pentazocine...

Ngày tải lên: 29/10/2013, 02:15

... tract is rapid and distinct visual hallucination takes place 45 min–1 h a er oral intake of about 20 àg of LSD [1]. e hallucination becomes most marked 2–3 h a er the intake and lasts for ... powerful hallucinogenic drugs of abuse. LSD was explosively abused in U.S .A. in the latter half of the 1960s. In Japan, the amount of seizure of LSD is much smaller than that of methamphetamine. ... Albert Hofmann who did synthesize the compound; the pharmaco- logical activity can be obtained by oral administration of as small as 2075 àg of LSD. e ab- sorption of LSD from the digestive tract...

Ngày tải lên: 08/11/2013, 01:15

... H, Nakajima K, Nishikawa M et al. (1991) Determination of methamphetamine and amphetamine in urine by headspace gas chromatography/mass spectrometry. Anal Sci 7:19–22 25) Shima N, Kamata T, ... intestinal tract and reaches its peak concentration in plasma about 2 h a er oral administration [21, 22].  e doses of 50, 75 and 125 mg in the usual “recreational” range for healthy human ... discrimination, TFA derivatization followed by GC/MS is applicable ( > Fig. 7.3).  e quantitative analysis data for MDAs in many kinds of clandestine tablets encountered in Japan are summarized...

Ngày tải lên: 08/11/2013, 01:15

... respectively. -Hydroxybutyric acid 244 Phencyclidine Center. At admission, he stared straight ahead, following commands but not responding verbally; the levels of serum creatinin kinase and aspartate aminotransferase ... Ishii and Yoshinao Katsumata Introduction Phencyclidine ( PCP) (> Fig. 8.1), a synthetic arylcyclohexylamine hallucinogen, had been  rst applied as an anaesthetic to animals and then to humans ... urine samples in cases of alleged sexual assault: case history. In: Salamore SJ (ed) Benzodiazepines and GHB: Detection and Pharmacology. Humana Press, Totowa, pp 127–144 11) Takahara J, Yunoki...

Ngày tải lên: 08/11/2013, 01:15

... MO, USA). Pure powder of perazine and clospi- razine was donated by Mitsubishi Welpharma, Osaka, Japan; that of  upentixol by Takeda Chem. Ind. Ltd., Osaka, Japan; that of thioproperazine by ... construct a calibration curve, consisting of drug concentration on the horizontal axis and of peak area ratio of a drug to IS on the vertical axis.  e above peak area ratio obtained from a specimen ... Yoshinao Katsumata Introduction Phenothiazine drugs, including chlorpromazine and levomepromazine, have been being widely used as neuroleptics ( major tranquilizers), antiparkinsonian drugs and...

Ngày tải lên: 15/12/2013, 12:15

... peak area ratios of haloperi- dol or bromperidol to IS are plotted against various concentrations of the test compound spiked to blank blood or urine to draw a calibration curve. A peak area ratio ... 13) Igarashi K, Kasuya F, Abe T et al. (1995) Simultaneous determination of haloperidol and its neurotoxic metabo- lite in plasma and brain tissue from schizophrenic patients treated with haloperidol ... dimethylsilyl coating, because trace amounts of drugs are easily adsorbed to their surfaces, causing variation of results. References 1) Seno H, Suzuki O, Kumazawa T et al. (1989) Rapid isolation with...

Ngày tải lên: 15/12/2013, 12:15

... tricyclic and tetracyclic antidepressants and carbamazepine obtained by HPLC-UV. A: carbamazepine, B: desipramine, C: maprotiline, D: nortriptyline, E: amoxapine, F: setiptiline, G: mianserin, H: ... by Takeda Chem. Ind. Ltd., Osaka, Japan; dosulepin by Kaken Pharmaceutical Co., Ltd., Tokyo, Japan; lofepramine by Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan; and setip- tiline by Mochida ... the reuptake of norepinephrine and serotonin and by accerelating the release of them at synaptic terminals of neurons in the brain. As characteristic structures of such drugs showing antidepressive...

Ngày tải lên: 15/12/2013, 12:15

... concentrations 290 Benzodiazepines Mass chromatograms of triazolam, 4-hydroxytriazolam, α-hydroxytriazolam and alprazolam (IS). A 100-ng aliquot each of triazolam, 4-hydroxytriazolam and α-hydroxytriazolam ... diazepam,  udiazepam,  urazepam, prazepam,  utoprazepam, dipotassium clorazepate, medazepam, chlordiazepoxide,  unitrazepam, alprazolam, midazolam, etizolam and brotizolam for both blood and ... cloxazolam, mexazolam,  utazolam and haloxazolam having oxazolo rings in their structures [1]. In such cases, the relatively low injection temperature and the use of a wide-bore capillary...

Ngày tải lên: 15/12/2013, 12:15

Ngày tải lên: 15/12/2013, 12:15

Ngày tải lên: 15/12/2013, 12:15